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ClinicalTrials.gov 71 recruiting now official registry

Head and Neck Squamous Cell Carcinoma clinical trials

71 of 125 indexed Head and Neck Squamous Cell Carcinoma trials are currently recruiting.

125 US clinical trials · 71 currently recruiting

Head and Neck Squamous Cell Carcinoma is the subject of 125 registered US clinical trials on ClinicalTrials.gov, 71 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 5 of these trials.

The research picture

Head and Neck Squamous Cell Carcinoma has 125 registered US clinical trials, 71 of them open to new participants right now, about 57% of the total.

71
recruiting participants now
57%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
5
top sponsor: AstraZeneca
Phase 168Phase 243Phase 33Phase 41

Active & Recent Trials

125 total, page 1 of 3

RECRUITING NA 532 participants

Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

Medical University of South Carolina

NCT05793151

RECRUITING Phase 1 523 participants

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

Merus B.V.

NCT03526835

RECRUITING Phase 1 512 participants

Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer (NSCLC), Head and Neck Squamous Cell Carcinoma (HNSCC) and Other Solid Tumors, Receiving Intravenous (IV) Infusion of Azirkitug (ABBV-514) Alone or in Combination With Budigalimab or Bevacizumab

AbbVie

NCT05005403

RECRUITING Phase 3 500 participants

A Phase 3 Study to Evaluate Petosemtamab Compared With Investigator's Choice Monotherapy in Previously Treated Head and Neck Squamous Cell Carcinoma Patients

Merus B.V.

NCT06496178

RECRUITING 500 participants

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

Tempus AI

NCT06163534

RECRUITING Phase 3 500 participants

A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)

Merus B.V.

NCT06525220

RECRUITING Phase 1 470 participants

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

SystImmune

NCT05983432

RECRUITING Phase 1 345 participants

A Study of NX-1607 in Adults With Advanced Malignancies

Nurix Therapeutics

NCT05107674

RECRUITING Phase 1 292 participants

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

Bicara Therapeutics

NCT04429542

RECRUITING Phase 1 242 participants

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

VM Oncology

NCT03556228

RECRUITING Phase 3 228 participants

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

Alliance for Clinical Trials in Oncology

NCT06992427

RECRUITING Phase 1 220 participants

A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours

Ipsen

NCT06305247

RECRUITING 220 participants

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

UNC Lineberger Comprehensive Cancer Center

NCT04564989

RECRUITING Phase 1 205 participants

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

Terremoto Biosciences

NCT07109726

RECRUITING Phase 1 200 participants

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

Volastra Therapeutics

NCT05902988

RECRUITING Phase 2 189 participants

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

ECOG-ACRIN Cancer Research Group

NCT02734537

RECRUITING Phase 1 170 participants

A Study to Investigate ALE.P02 as Monotherapy in Adult Patients With Selected CLDN1+ Solid Tumors

Alentis Therapeutics

NCT06747585

RECRUITING Phase 1 168 participants

A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

OncoNano Medicine

NCT06022029

RECRUITING Phase 1 166 participants

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

Epkin

NCT06789172

RECRUITING NA 160 participants

Virtual Reality 3D-Surgery Modeling to Enhance Head and Neck Cancer Surgery Quality

Thomas Jefferson University

NCT05031910

RECRUITING Phase 1 140 participants

Study of TU2218 in Combination With KEYTRUDA®(Pembrolizumab) in Patients With Advanced Solid Tumors

TiumBio Co.

NCT05784688

RECRUITING Phase 1 134 participants

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

Neonc Technologies

NCT06047379

RECRUITING Phase 1 121 participants

Study of NEO-201 in Solid Tumors Expansion Cohorts

Precision Biologics

NCT03476681

RECRUITING Phase 2 120 participants

A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)

University of Texas Southwestern Medical Center

NCT05576974

RECRUITING NA 118 participants

Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation

Emory University

NCT06662058

RECRUITING Phase 1 113 participants

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

Fate Therapeutics

NCT07216105

RECRUITING Phase 2 110 participants

Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors

AstraZeneca

NCT06535607

RECRUITING Phase 2 108 participants

3-5 FrAction Stereotactic Body Radiation Therapy for Palliation of Head and Neck Squamous Cell Carcinoma: the FAST Phase II Randomized Trial

M.D. Anderson Cancer Center

NCT05674396

RECRUITING NA 100 participants

Evaluation of Radiobiological Effects in Skin Toxicities Head and Neck Cancer Patients With PBS Proton Therapy

Covenant Health Cancer Center

NCT06183268

RECRUITING Phase 2 98 participants

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

NRG Oncology

NCT06532279

RECRUITING Phase 1 96 participants

A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas

Dren Bio

NCT06999187

RECRUITING Phase 2 92 participants

GB1211 and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell Carcinoma

Providence Health & Services

NCT05913388

RECRUITING Phase 1 90 participants

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

Clasp Therapeutics

NCT06778863

RECRUITING Phase 1 90 participants

TT-10 (PORT-6) and TT-4 (PORT-7) as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors

Portage Biotech

NCT04969315

RECRUITING Phase 1 90 participants

A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone

Boehringer Ingelheim

NCT06806852

RECRUITING Phase 2 87 participants

Phase 2 Trial of Voyager V1 in Combination With Cemiplimab in Cancer Patients

Vyriad

NCT04291105

RECRUITING Phase 1 87 participants

Study of CHS-114 in Participants With Advanced Solid Tumors

Coherus Oncology

NCT05635643

RECRUITING Phase 1 73 participants

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

Compass Therapeutics

NCT06150664

RECRUITING Phase 1 70 participants

A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours

AstraZeneca

NCT06147037

RECRUITING Phase 2 66 participants

Olanzapine for Managing Anorexia in Head and Neck Cancer Patients Undergoing Chemoradiation, MACRO Trial

Roswell Park Cancer Institute

NCT06995508

RECRUITING Phase 2 61 participants

Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)

University of Maryland, Baltimore

NCT06088381

RECRUITING Phase 1 60 participants

(89Zr Panitumumab) With PET/CT for Diagnosing Metastases in Patients With Head and Neck Squamous Cell Carcinoma

Eben Rosenthal

NCT05747625

RECRUITING Phase 1 60 participants

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

AstraZeneca

NCT07115043

RECRUITING Phase 1 60 participants

A Study of VET3-TGI in Patients With Solid Tumors

KaliVir Immunotherapeutics

NCT06444815

RECRUITING Early Phase 1 48 participants

Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy

Vanderbilt-Ingram Cancer Center

NCT05996432

RECRUITING Phase 1 46 participants

A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

AstraZeneca

NCT05877599

RECRUITING Phase 1 45 participants

Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

Baylor College of Medicine

NCT03740256

RECRUITING Phase 2 44 participants

Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

National Cancer Institute (NCI)

NCT06980038

RECRUITING Phase 2 43 participants

A Phase II Study of ACR-368 and Low Dose Gemcitabine in R/M HNSCC

H. Lee Moffitt Cancer Center and Research Institute

NCT06597565

RECRUITING Phase 1 40 participants

Evaluating the Use of Dual Imaging Techniques for Detection of Disease in Patients With Head and Neck Cancer

Vanderbilt-Ingram Cancer Center

NCT05945875

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Phase Distribution

PhaseTrial count
Phase 1 68
Phase 2 43
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Head and Neck Squamous Cell Carcinoma Trial Landscape

125 indexed Head and Neck Squamous Cell Carcinoma studies · 71 recruiting (57%).

Phase mix: 4 late (III/IV) vs 111 early (I/II).

Top sponsor: AstraZeneca (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Head and Neck Squamous Cell Carcinoma?

PlainTrial tracks 125 US clinical trials for Head and Neck Squamous Cell Carcinoma, of which 71 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Head and Neck Squamous Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.