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NCT04564989 · ClinicalTrials.gov registry record

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

A clinical trial of Head and Neck Squamous Cell Carcinoma and Oropharyngeal Squamous Cell Carcinoma, sponsored by UNC Lineberger Comprehensive Cancer Center.

Recruiting
Registry status
220
Enrollment target
3
Study locations

NCT04564989 is a study of Head and Neck Squamous Cell Carcinoma and Oropharyngeal Squamous Cell Carcinoma that is actively recruiting participants, run by UNC Lineberger Comprehensive Cancer Center. The registered enrollment target is 220 participants, above the 115-participant average among 124 other Head and Neck Squamous Cell Carcinoma trials with a reported enrollment target (91% higher). The trial reports 3 study locations across 3 states.

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The verdict

NCT04564989, a study of Head and Neck Squamous Cell Carcinoma and Oropharyngeal Squamous Cell Carcinoma, is actively recruiting participants, sponsored by UNC Lineberger Comprehensive Cancer Center.

RECRUITING
Registry status
220 participants
Enrollment target
3
Study locations

Study Summary

The primary goal of this study is to examine whether recurrence of HPV-associated OPSCC can be predicted by two factors: 1) mutations in genes called TRAF3 and CYLD, and 2) measurements of circulating HPV DNA in blood plasma. The study will also investigate whether HPV integration is associated with TRAF3 and CYLD mutations, and whether recurrence prediction improves when looking at HPV integration along with TRAF3 and CYLD mutations.

Conditions Studied

Head and Neck Squamous Cell Carcinoma Oropharyngeal Squamous Cell Carcinoma Carcinoma, Squamous Cell Oropharynx Squamous Cell Carcinoma

Study Locations (3)

Minnesota

  • Mayo Clinic - Rochester

North Carolina

  • University of North Carolina at Chapel Hill - Chapel Hill

South Carolina

  • Trident Medical Center (HCA Healthcare ) - North Charleston

Trial Details

FieldValue
Enrollment Target 220 participants
Start Date 2020-11-19
Est. Completion 2033-11

Sponsor

UNC Lineberger Comprehensive Cancer Center

366 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04564989

The ClinicalTrials.gov registry entry for NCT04564989 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 220 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 115-participant average among 124 other Head and Neck Squamous Cell Carcinoma trials with a reported enrollment target (91% higher). The listed sponsor is UNC Lineberger Comprehensive Cancer Center, which has 366 total studies on file at ClinicalTrials.gov.

The record links to 4 conditions, with Head and Neck Squamous Cell Carcinoma appearing as the primary indexed condition, and to 0 interventions.

NCT04564989 reports 3 study locations spanning 3 distinct geographic areas - top geographies include Minnesota, North Carolina, South Carolina.

Frequently Asked Questions

What is clinical trial NCT04564989 about?

NCT04564989 is a clinical study titled "Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC". The primary goal of this study is to examine whether recurrence of HPV-associated OPSCC can be predicted by two factors: 1) mutations in genes called TRAF3 and CYLD, and 2) measurements of circulating HPV DNA in blood plasma. The study will also investigate whether HPV integration is associated with...

What is the current status of trial NCT04564989?

This trial is currently recruiting. The enrollment target is 220 participants. The study started on 2020-11-19. Estimated completion is 2033-11.

What conditions does trial NCT04564989 study?

This clinical trial studies the following conditions: Head and Neck Squamous Cell Carcinoma, Oropharyngeal Squamous Cell Carcinoma, Carcinoma, Squamous Cell, Oropharynx Squamous Cell Carcinoma.

Who is sponsoring clinical trial NCT04564989?

This trial is sponsored by UNC Lineberger Comprehensive Cancer Center, which has 366 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04564989 being conducted?

This trial has 3 study locations across Minnesota, North Carolina, South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.