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NCT06525220 · ClinicalTrials.gov registry record · Phase 3
A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)
A Phase 3 study of Head and Neck Squamous Cell Carcinoma, sponsored by Merus B.V..
- Recruiting
- Registry status
- Phase 3
- Development phase
- 500
- Enrollment target
- 20
- Study locations
NCT06525220: Recruiting Phase 3 study of Head and Neck Squamous Cell Carcinoma, sponsored by Merus B.V..
NCT06525220 is a Phase 3 study of Head and Neck Squamous Cell Carcinoma that is actively recruiting participants, run by Merus B.V.. The registered enrollment target is 500 participants, above the 113-participant average among 124 other Head and Neck Squamous Cell Carcinoma trials with a reported enrollment target (342% higher). The trial reports 20 study locations across 14 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06525220, a Phase 3 study of Head and Neck Squamous Cell Carcinoma, is actively recruiting participants, sponsored by Merus B.V..
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 500 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a Phase 3 randomized, open-label study to evaluate the efficacy and safety of petosemtamab plus pembrolizumab vs pembrolizumab in first-line treatment of recurrent or metastatic PD-L1+ head and neck squamous cell carcinoma.
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG Petosemtamab
Study Locations (20)
Florida
- Site 14 - Fort Myers
- Site 48 - Orlando
- Site 8 - Orlando
- Site 21 - St. Petersburg
- Site 20 - West Palm Beach
California
- Site 36 - La Jolla
- Site 27 - Los Angeles
- Site 16 - Palo Alto
Alabama
- Site 164 - Mobile
Delaware
- Site 19 - Newark
District of Columbia
- Site 108 - Washington D.C.
Georgia
- Site 171 - Atlanta
Illinois
- Site 50 - Chicago
Kentucky
- Site 2 - Louisville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 500 participants |
| Start Date | 2024-09-25 |
| Est. Completion | 2030-07 |
| Phase | Phase 3 |
What NCT06525220 shows while recruiting
NCT06525220 is an interventional study that assigns participants to a tested intervention. The registered 500 participants enrollment target is mid-sized for trials with a published cap, above the 113-participant average among 124 other Head and Neck Squamous Cell Carcinoma trials with a reported enrollment target (342% higher).
The record links to 1 condition, with Head and Neck Squamous Cell Carcinoma appearing as the primary indexed condition, and to 2 interventions - of which Pembrolizumab is the first listed.
NCT06525220 names 20 study sites across 14 states, led by Florida, California, Alabama.
Frequently Asked Questions
What is clinical trial NCT06525220 about?
NCT06525220 is a clinical study titled "A Phase 3 Study to Evaluate Petosemtamab Plus Pembrolizumab vs Pembrolizumab in First-line Treatment of Head and Neck Cancer (LiGeR - HN1)". This is a Phase 3 randomized, open-label study to evaluate the efficacy and safety of petosemtamab plus pembrolizumab vs pembrolizumab in first-line treatment of recurrent or metastatic PD-L1+ head and neck squamous cell carcinoma.
What is the current status of trial NCT06525220?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 500 participants. The study started on 2024-09-25. Estimated completion is 2030-07.
What conditions does trial NCT06525220 study?
This clinical trial studies the following conditions: Head and Neck Squamous Cell Carcinoma.
What interventions are being tested in trial NCT06525220?
The interventions under investigation include: Pembrolizumab (DRUG), Petosemtamab (DRUG).
Who is sponsoring clinical trial NCT06525220?
This trial is sponsored by Merus B.V., which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06525220 being conducted?
This trial has 20 study locations across Alabama, California, Delaware, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06525220's enrollment target sits among peer trials
500 6th of 124 higher than 117 of 124 other Head and Neck Squamous Cell Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Head and Neck Squamous Cell Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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