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NCT05902988 · ClinicalTrials.gov registry record · Phase 1

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

A Phase 1 study of Advanced Solid Tumor and Head and Neck Squamous Cell Carcinoma, sponsored by Volastra Therapeutics.

Recruiting
Registry status
Phase 1
Development phase
200
Enrollment target
14
Study locations

NCT05902988 is a Phase 1 study of Advanced Solid Tumor and Head and Neck Squamous Cell Carcinoma that is actively recruiting participants, run by Volastra Therapeutics. The registered enrollment target is 200 participants, roughly in line with the 192-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target. The trial reports 14 study locations across 12 states.

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The verdict

NCT05902988, a Phase 1 study of Advanced Solid Tumor and Head and Neck Squamous Cell Carcinoma, is actively recruiting participants, sponsored by Volastra Therapeutics.

RECRUITING
Registry status
Phase 1
Development phase
200 participants
Enrollment target
14
Study locations

Study Summary

This is a first-in-human phase I/II study to examine the safety, tolerability and preliminary efficacy of VLS-1488 in subjects with advanced cancers.

Conditions Studied

Advanced Solid Tumor Head and Neck Squamous Cell Carcinoma Triple Negative Breast Cancer Squamous Non-Small Cell Lung Cancer Uterine Serous Carcinoma Uterine Carcinosarcoma High Grade Serous Adenocarcinoma of Ovary Endometrium Cancer Ovarian Carcinosarcoma Chromosomal Instability

Interventions

  • DRUG VLS-1488

Study Locations (14)

California

  • University of Southern California - Los Angeles
  • Hoag Memorial Hospital - Newport Beach

Michigan

  • University of Michigan - Ann Arbor
  • START Midwest - Grand Rapids

Colorado

  • University of Colorado Cancer Center - Aurora

Connecticut

  • Yale Cancer Center - New Haven

Illinois

  • Kellogg Cancer Center - Evanston

Indiana

  • Community Health Network - Indianapolis

Maryland

  • Johns Hopkins Sidney Kimmel Comprehensive Cancer Center - Baltimore

New York

  • Memorial Sloan Kettering Cancer Center - New York

Trial Details

FieldValue
Enrollment Target 200 participants
Start Date 2023-10-18
Est. Completion 2026-12
Phase Phase 1

Sponsor

Volastra Therapeutics

3 total trials

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What the Registry Record Tells You About NCT05902988

The ClinicalTrials.gov registry entry for NCT05902988 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect, roughly in line with the 192-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target. The listed sponsor is Volastra Therapeutics, which has 3 total studies on file at ClinicalTrials.gov.

The record links to 10 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 1 intervention - of which VLS-1488 is the first listed.

NCT05902988 reports 14 study locations spanning 12 distinct geographic areas - top geographies include California, Michigan, Colorado.

Frequently Asked Questions

What is clinical trial NCT05902988 about?

NCT05902988 is a clinical study titled "A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer". This is a first-in-human phase I/II study to examine the safety, tolerability and preliminary efficacy of VLS-1488 in subjects with advanced cancers.

What is the current status of trial NCT05902988?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 200 participants. The study started on 2023-10-18. Estimated completion is 2026-12.

What conditions does trial NCT05902988 study?

This clinical trial studies the following conditions: Advanced Solid Tumor, Head and Neck Squamous Cell Carcinoma, Triple Negative Breast Cancer, Squamous Non-Small Cell Lung Cancer, Uterine Serous Carcinoma.

What interventions are being tested in trial NCT05902988?

The interventions under investigation include: VLS-1488 (DRUG).

Who is sponsoring clinical trial NCT05902988?

This trial is sponsored by Volastra Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05902988 being conducted?

This trial has 14 study locations across California, Colorado, Connecticut, Illinois, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.