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A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer
NCT05902988 · View on ClinicalTrials.gov ↗
Study Summary
This is a first-in-human phase I/II study to examine the safety, tolerability and preliminary efficacy of VLS-1488 in subjects with advanced cancers.
Conditions Studied
Interventions
- DRUG VLS-1488
Study Locations (14)
California
- University of Southern California — Los Angeles
- Hoag Memorial Hospital — Newport Beach
Michigan
- University of Michigan — Ann Arbor
- START Midwest — Grand Rapids
Colorado
- University of Colorado Cancer Center — Aurora
Connecticut
- Yale Cancer Center — New Haven
Illinois
- Kellogg Cancer Center — Evanston
Indiana
- Community Health Network — Indianapolis
Maryland
- Johns Hopkins Sidney Kimmel Comprehensive Cancer Center — Baltimore
New York
- Memorial Sloan Kettering Cancer Center — New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2023-10-18 |
| Est. Completion | 2026-12 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05902988
The ClinicalTrials.gov registry entry for NCT05902988 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Volastra Therapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 10 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 1 intervention — of which VLS-1488 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05902988 reports 14 study locations spanning 12 distinct geographic areas — top geographies include California, Michigan, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05902988 about?
NCT05902988 is a clinical study titled "A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer". This is a first-in-human phase I/II study to examine the safety, tolerability and preliminary efficacy of VLS-1488 in subjects with advanced cancers.
What is the current status of trial NCT05902988?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 200 participants. The study started on 2023-10-18. Estimated completion is 2026-12.
What conditions does trial NCT05902988 study?
This clinical trial studies the following conditions: Advanced Solid Tumor, Head and Neck Squamous Cell Carcinoma, Triple Negative Breast Cancer, Uterine Serous Carcinoma, Uterine Carcinosarcoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05902988?
The interventions under investigation include: VLS-1488 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05902988?
This trial is sponsored by Volastra Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05902988 being conducted?
This trial has 14 study locations across California, Colorado, Connecticut, Illinois, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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