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NCT05996432 · ClinicalTrials.gov registry record · Early Phase 1
Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy
A Early Phase 1 study of Head and Neck Squamous Cell Carcinoma and Brain Metastases, sponsored by Vanderbilt-Ingram Cancer Center.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 48
- Enrollment target
- 1
- Study location
NCT05996432: Recruiting Early Phase 1 study of Head and Neck Squamous Cell Carcinoma and Brain Metastases, sponsored by Vanderbilt-Ingram Cancer Center.
NCT05996432 is a Early Phase 1 study of Head and Neck Squamous Cell Carcinoma and Brain Metastases that is actively recruiting participants, run by Vanderbilt-Ingram Cancer Center. The registered enrollment target is 48 participants, below the 117-participant average among 124 other Head and Neck Squamous Cell Carcinoma trials with a reported enrollment target (59% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05996432, a Early Phase 1 study of Head and Neck Squamous Cell Carcinoma and Brain Metastases, is actively recruiting participants, sponsored by Vanderbilt-Ingram Cancer Center.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 48 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will apply novel MRI approaches with established sensitivity to tissue oxygen consumption and perfusion to predict hypoxia-associated radiation resistance, manifested as tumor recurrence and progression post-treatment.
Primary Outcome
MRI assessed oxygen extraction fraction (OEF, %)
Conditions Studied
Interventions
- PROCEDURE Magnetic Resonance Imaging (MRI)
- PROCEDURE Positron Emission Tomography (PET)
- DRUG 18F-fluoromisonidazole
Study Locations (1)
Tennessee
- Vanderbilt University/Ingram Cancer Center - Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 48 participants |
| Start Date | 2023-05-17 |
| Est. Completion | 2029-05-31 |
| Phase | Early Phase 1 |
What NCT05996432 shows while recruiting
NCT05996432 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 48 participants, a relatively small participant target, below the 117-participant average among 124 other Head and Neck Squamous Cell Carcinoma trials with a reported enrollment target (59% lower).
The record links to 2 conditions, with Head and Neck Squamous Cell Carcinoma appearing as the primary indexed condition, and to 3 interventions - of which Magnetic Resonance Imaging (MRI) is the first listed.
NCT05996432 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT05996432 about?
NCT05996432 is a clinical study titled "Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy". This study will apply novel MRI approaches with established sensitivity to tissue oxygen consumption and perfusion to predict hypoxia-associated radiation resistance, manifested as tumor recurrence and progression post-treatment.
What is the current status of trial NCT05996432?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 48 participants. The study started on 2023-05-17. Estimated completion is 2029-05-31.
What conditions does trial NCT05996432 study?
This clinical trial studies the following conditions: Head and Neck Squamous Cell Carcinoma, Brain Metastases.
What interventions are being tested in trial NCT05996432?
The interventions under investigation include: Magnetic Resonance Imaging (MRI) (PROCEDURE), Positron Emission Tomography (PET) (PROCEDURE), 18F-fluoromisonidazole (DRUG).
Who is sponsoring clinical trial NCT05996432?
This trial is sponsored by Vanderbilt-Ingram Cancer Center, which has 189 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05996432 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05996432's enrollment target sits among peer trials
48 69th of 124 higher than 56 of 124 other Head and Neck Squamous Cell Carcinoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Head and Neck Squamous Cell Carcinoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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