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RECRUITING Phase 1

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

NCT06047379 · View on ClinicalTrials.gov ↗

Study Summary

This multi-site, Phase 1/2 clinical trial is an open-label study to identify the safety, pharmacokinetics, and efficacy of a repeated dose regimen of NEO212 alone for the treatment of patients with radiographically-confirmed progression of Astrocytoma IDH- mutant, Glioblastoma IDH-wildtype, and the safety, pharmacokinetics and efficacy of a repeated dose regimen of NEO212 when given with select SOC for the treatment of solid tumor patients with radiographically confirmed uncontrolled metastases to the brain. The study will have three phases, Phase 1, Phase 2a and Phase 2b.

Interventions

  • DRUG Pembrolizumab
  • DRUG Nivolumab
  • DRUG Ipilimumab
  • DRUG Regorafenib
  • DRUG NEO212 Oral Capsule

Study Locations (6)

California

  • Precision NextGen Oncology — Beverly Hills
  • OPN Healthcare, Inc — Glendale
  • University of Southern California — Los Angeles

Tennessee

  • Vanderbilt University Medical Center — Nashville

Texas

  • Baylor, Scott and White Research Institute — Dallas

Washington

  • Northwest Medical Specialties — Tacoma

Trial Details

FieldValue
Enrollment Target 134 participants
Start Date 2023-11-01
Est. Completion 2027-08-31
Phase Phase 1

Sponsor

Neonc Technologies

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06047379

The ClinicalTrials.gov registry entry for NCT06047379 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 134 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Neonc Technologies, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Colorectal Cancer appearing as the primary indexed condition, and to 5 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06047379 reports 6 study locations spanning 4 distinct geographic areas — top geographies include California, Tennessee, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06047379 about?

NCT06047379 is a clinical study titled "Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis". This multi-site, Phase 1/2 clinical trial is an open-label study to identify the safety, pharmacokinetics, and efficacy of a repeated dose regimen of NEO212 alone for the treatment of patients with radiographically-confirmed progression of Astrocytoma IDH- mutant, Glioblastoma IDH-wildtype, and the ...

What is the current status of trial NCT06047379?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 134 participants. The study started on 2023-11-01. Estimated completion is 2027-08-31.

What conditions does trial NCT06047379 study?

This clinical trial studies the following conditions: Colorectal Cancer, Gastric Cancer, Cervical Cancer, Esophageal Cancer, Head and Neck Squamous Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06047379?

The interventions under investigation include: Pembrolizumab (DRUG), Nivolumab (DRUG), Ipilimumab (DRUG), Regorafenib (DRUG), NEO212 Oral Capsule (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06047379?

This trial is sponsored by Neonc Technologies, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06047379 being conducted?

This trial has 6 study locations across California, Tennessee, Texas, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial