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ClinicalTrials.gov 71 recruiting now official registry

Head and Neck Squamous Cell Carcinoma clinical trials

71 of 125 indexed Head and Neck Squamous Cell Carcinoma trials are currently recruiting.

125 US clinical trials · 71 currently recruiting

Head and Neck Squamous Cell Carcinoma is the subject of 125 registered US clinical trials on ClinicalTrials.gov, 71 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 111 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 5 of these trials.

The research picture

Head and Neck Squamous Cell Carcinoma has 125 registered US clinical trials, 71 of them open to new participants right now, about 57% of the total.

71
recruiting participants now
57%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
5
top sponsor: AstraZeneca
Phase 168Phase 243Phase 33Phase 41

Active & Recent Trials

125 total, page 2 of 3

RECRUITING Phase 1 40 participants

A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer

Memorial Sloan Kettering Cancer Center

NCT04722523

RECRUITING Phase 2 38 participants

Cetuximab After Immunotherapy for the Treatment of Head and Neck Squamous Cell Cancer

Wake Forest University Health Sciences

NCT04375384

RECRUITING Phase 2 34 participants

Single-Center Eval of Clinical & Radiological Benefit AHCC in Combo W/ SOC Tx for HPV+ Pts W/ HNSCC

University of California, Irvine

NCT06693323

RECRUITING Phase 1 33 participants

Phase 1 Trial of ZM008 as Single Agent and in Combination With Pembrolizumab in Patients With Advanced Solid Tumors

Zumutor Biologics

NCT06451497

RECRUITING Phase 1 30 participants

Dosing Study of Radiation Combined With Tislelizumab and Pamiparib in Patients With Previously Treated Head and Neck Cancer

University of Chicago

NCT05526924

RECRUITING Phase 2 30 participants

A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer

University of Chicago

NCT05420948

RECRUITING Phase 2 30 participants

Neoadjuvant Pembrolizumab and IO102-103 for Squamous Cell Carcinoma of the Head and Neck (SCCHN).

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05977907

RECRUITING Phase 1 30 participants

Evaluating 111In Panitumumab for Nodal Staging in Head and Neck Cancer

Vanderbilt-Ingram Cancer Center

NCT05901545

RECRUITING Phase 1 29 participants

NT219 Combined With Standard of Care Biologic Therapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

University of Colorado, Denver

NCT06919666

RECRUITING Phase 2 28 participants

Preoperative Pembrolizumab and Chemotherapy in Resectable, Recurrent HNSCC

Dana-Farber Cancer Institute

NCT05726370

RECRUITING Phase 2 25 participants

PD-L1 t-haNK, NAI IL-15sa and Cetuximab for Recurrent, Metastatic HNSCC

Glenn J. Hanna

NCT06239220

RECRUITING Phase 4 25 participants

Methylnatrexone In Resectable Head and Neck Squamous Cell Carcinoma (MINK). A "Window of Opportunity" Pilot Study.

M.D. Anderson Cancer Center

NCT06162377

RECRUITING Phase 2 21 participants

Phase II Study of Neoadjuvant Cetuximab and Cemiplimab in Patients Undergoing Surgery for HNSCC

H. Lee Moffitt Cancer Center and Research Institute

NCT06855212

RECRUITING Early Phase 1 20 participants

Comparing an Investigational Scan (F-18 NaF PET/CT) to Standard of Care Imaging (F-18 FDG PET/CT) for Evaluating Vascular Complications in Patients Receiving Radiation Therapy for Head and Neck Cancer

Emory University

NCT06914999

RECRUITING Early Phase 1 15 participants

PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, Sabestomig, and AZD9592 in HNSCC

Presage Biosciences

NCT06366451

RECRUITING Early Phase 1 14 participants

Comparison of 89Zr Panitumumab and (18)F-Fluorodeoxyglucose to Identify Head and Neck Squamous Cell Carcinoma

University of Alabama at Birmingham

NCT05183048

RECRUITING 13 participants

3D Specimen Maps for RT Planning

Vanderbilt University Medical Center

NCT05743569

RECRUITING NA 12 participants

A Study of the Use of Fat Flap Reconstruction to Reduce Neck Injury After Cancer Treatment

Memorial Sloan Kettering Cancer Center

NCT05889091

RECRUITING Early Phase 1 12 participants

A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid Tumors

Pure Biologics S.A.

NCT06700070

RECRUITING Phase 2 12 participants

A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck Cancer

Memorial Sloan Kettering Cancer Center

NCT05544136

RECRUITING Early Phase 1 12 participants

Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma

University of Wisconsin, Madison

NCT06308913

ACTIVE NOT RECRUITING Phase 1 1,410 participants

Phase I-II, FIH, TROP2 ADC, Advanced Unresectable/Metastatic Solid Tumors, Refractory to Standard Therapies (KL264-01)

Klus Pharma

NCT04152499

ACTIVE NOT RECRUITING Phase 2 600 participants

Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Exelixis

NCT06082167

ACTIVE NOT RECRUITING Phase 1 302 participants

Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400

AbbVie

NCT06084481

ACTIVE NOT RECRUITING Phase 1 194 participants

Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination

Merus B.V.

NCT04868877

ACTIVE NOT RECRUITING Phase 2 189 participants

Evorpacept (ALX148) in Combination With Pembrolizumab in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-03)

ALX Oncology

NCT04675294

ACTIVE NOT RECRUITING Phase 1 180 participants

P-MUC1C-ALLO1 Allogeneic CAR-T Cells in the Treatment of Subjects With Advanced or Metastatic Solid Tumors

Poseida Therapeutics

NCT05239143

ACTIVE NOT RECRUITING Phase 2 172 participants

Evorpacept (ALX148) in Combination With Pembrolizumab and Chemotherapy in Patients With Advanced Head and Neck Squamous Cell Carcinoma (ASPEN-04)

ALX Oncology

NCT04675333

ACTIVE NOT RECRUITING Phase 2 160 participants

A Study of Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma

BeiGene

NCT05909904

ACTIVE NOT RECRUITING Phase 2 128 participants

Paclitaxel, Carboplatin and Cetuximab (PCC) With Cetuximab, Docetaxel, Cisplatin and Fluorouracil (C-TPF) in Previously Untreated Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma

M.D. Anderson Cancer Center

NCT01154920

ACTIVE NOT RECRUITING Phase 2 126 participants

Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer

Loren Mell, MD

NCT03383094

ACTIVE NOT RECRUITING Phase 2 100 participants

Study of Novel Treatment Combination Therapies in Participants With Head and Neck Squamous Cell Carcinoma Regardless of PD-L1 Expression Status; Substudy-01

Gilead Sciences

NCT06727565

ACTIVE NOT RECRUITING Phase 2 74 participants

Cisplatin, Nab-Paclitaxel, and Cetuximab (CACTUX) in Patients With Incurable Head and Neck Squamous Cell Carcinoma

Washington University School of Medicine

NCT02270814

ACTIVE NOT RECRUITING Phase 1 72 participants

A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors

HiFiBiO Therapeutics

NCT05238883

ACTIVE NOT RECRUITING NA 72 participants

Intensive Symptom Surveillance Guided by Machine Learning-Directed Risk Stratification in Patients With Non-Metastatic Head and Neck Cancer, The INSIGHT Trial

Roswell Park Cancer Institute

NCT05338905

ACTIVE NOT RECRUITING Phase 1 70 participants

Study of ARRY-614 Plus Either Nivolumab or Nivolumab+Ipilimumab

Dan Zandberg

NCT04074967

ACTIVE NOT RECRUITING Phase 1 67 participants

Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas

Immunitas Therapeutics

NCT05565417

ACTIVE NOT RECRUITING Phase 2 65 participants

Neoadjuvant Cemiplimab for the Treatment of Resectable NSCLC, HCC, and HNSCC in Adult Patients

Regeneron Pharmaceuticals

NCT03916627

ACTIVE NOT RECRUITING Phase 2 63 participants

IO102-IO103 in Combination With Pembrolizumab as First-line Treatment for Patients With Metastatic NSCLC, SCCHN, or mUBC

IO Biotech

NCT05077709

ACTIVE NOT RECRUITING Phase 1 61 participants

Recombinant EphB4-HSA Fusion Protein With Standard Chemotherapy Regimens in Treating Patients With Advanced or Metastatic Solid Tumors

University of Southern California

NCT02495896

ACTIVE NOT RECRUITING Phase 2 60 participants

MIT-001 for Prevention of CCRT-Induced OM in HNSCC Patients

MitoImmune Therapeutics

NCT04651634

ACTIVE NOT RECRUITING Phase 2 52 participants

Testing the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab) in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck

National Cancer Institute (NCI)

NCT05172258

ACTIVE NOT RECRUITING Phase 2 46 participants

FID-007 and Cetuximab in Treating Patients With Advanced Head and Neck Squamous Cell Carcinoma

Fulgent Pharma

NCT06332092

ACTIVE NOT RECRUITING Phase 1 43 participants

Ramucirumab + Pembrolizumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Washington University School of Medicine

NCT03650764

ACTIVE NOT RECRUITING Phase 1 43 participants

Testing the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation for Head and Neck Cancer

National Cancer Institute (NCI)

NCT02567422

ACTIVE NOT RECRUITING Phase 2 40 participants

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

ImmunityBio

NCT03228667

ACTIVE NOT RECRUITING Phase 1 35 participants

Study of MEDI0562 Prior to Surgical Resection in Head and Neck Squamous Cell Carcinoma (HNSCC) or Melanoma

Providence Health & Services

NCT03336606

ACTIVE NOT RECRUITING Phase 2 28 participants

Neoadjuvant Immunoradiotherapy in Head & Neck Cancer (NIRT 2-HNC)

Providence Health & Services

NCT04938609

ACTIVE NOT RECRUITING Phase 1 27 participants

CD40 Agonist and PD-1 Inhibitor in HNSCC

University of Pennsylvania

NCT06159621

ACTIVE NOT RECRUITING Phase 2 26 participants

Los Tres Paso: Neoadjuvant Palbociclib Monotherapy, Concurrent Chemoradiation Therapy, Adjuvant Palbociclib Monotherapy in Patients With p16INK4a Negative, HPV-Unrelated Head and Neck Squamous Cell Carcinoma

Washington University School of Medicine

NCT03389477

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Phase Distribution

PhaseTrial count
Phase 1 68
Phase 2 43
Phase 3 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Head and Neck Squamous Cell Carcinoma Trial Landscape

125 indexed Head and Neck Squamous Cell Carcinoma studies · 71 recruiting (57%).

Phase mix: 4 late (III/IV) vs 111 early (I/II).

Top sponsor: AstraZeneca (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Head and Neck Squamous Cell Carcinoma?

PlainTrial tracks 125 US clinical trials for Head and Neck Squamous Cell Carcinoma, of which 71 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Head and Neck Squamous Cell Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.