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Head and Neck Cancer clinical trials
89 of 260 indexed Head and Neck Cancer trials are currently recruiting.
260 US clinical trials · 89 currently recruiting
Head and Neck Cancer is the subject of 260 registered US clinical trials on ClinicalTrials.gov, 89 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 137 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 19 of these trials.
The research picture
Head and Neck Cancer has 260 registered US clinical trials, 89 of them open to new participants right now, about 34% of the total.
- 89
- recruiting participants now
- 34%
- of trials open to enrollment
- 13
- in Phase 3–4 (later-stage)
- 19
- top sponsor: M.D. Anderson Cancer Center
Active & Recent Trials
260 total, page 5 of 6
Nutritional Risk and Mucositis in Patients With Head and Neck Carcinoma Receiving Chemoradiation
University of Arkansas
NCT00577902
Nab-Paclitaxel, Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer
University of Texas Southwestern Medical Center
NCT00833261
Radiation Therapy, Combination Chemotherapy, and Amifostine in Treating Patients With Head and Neck Cancer
University of Miami
NCT00003582
Pemetrexed (Alimta) in Patients With Head and Neck Squamous Cell Cancer
M.D. Anderson Cancer Center
NCT00507858
Safety and Efficacy of MEDI0457 and Durvalumab in Participants With Human Papilloma Virus (HPV) Associated Recurrent/Metastatic Head and Neck Cancer
MedImmune
NCT03162224
Role of Immune Activation in Response of Head and Neck Squamous Cell Carcinoma to Therapy
Icahn School of Medicine at Mount Sinai
NCT01358097
Curcumin Biomarker Trial in Head and Neck Cancer
Louisiana State University Health Sciences Center Shreveport
NCT01160302
Outcomes of Prophylactic Swallowing Therapy in Patients Undergoing Definitive Chemoradiation for Head and Neck Cancer
University of Miami
NCT03435471
Proactive Psychiatry Consultation for Patients With Cancer and Severe Mental Illness
Massachusetts General Hospital
NCT02594696
MRI for Eval Tumor & Node Response & Normal Tissue Function to Concurrent Chemo & Radiation Therapy in H&N Cancer (GCC1043)
University of Maryland, Baltimore
NCT01768442
Bevacizumab, Cetuximab, and Cisplatin With IMRT (Intensity-Modulated Radiation Therapy) for Patients With Stage III/IV Head and Neck Squamous Cell Carcinoma
Memorial Sloan Kettering Cancer Center
NCT00968435
Radioimmunotherapy With or Without Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Thyroid Cancer
Garden State Cancer Center at the Center for Molecular Medicine and Immunology
NCT00004048
Paclitaxel and Cisplatin Plus Radiation Therapy Followed by Filgrastim in Treating Patients With Recurrent Head and Neck Cancer or Lung Cancer
Fox Chase Cancer Center
NCT00021333
Study of KeraStat Cream for Radiation Dermatitis During Head and Neck Radiotherapy
Wake Forest University Health Sciences
NCT04173247
Angiogenic and EGFR Blockade With Curative Chemoradiation for Advanced Head and Neck Cancer
David M. Brizel, MD
NCT00140556
Gefitinib in Treating Patients With Locally Advanced or Metastatic Thyroid Cancer That Did Not Respond to Iodine Therapy
Massachusetts General Hospital
NCT00095836
Functional and Aesthetic Outcomes After Mandible Reconstruction With Fibula Osteomyocutaneous Free Flaps
Memorial Sloan Kettering Cancer Center
NCT02572869
Preoperative Immune Checkpoint Inhibitor for Patients With Primary Untreated or Recurrent/Metastatic SCCHN
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT03878979
Combretastatin A4 Phosphate in Treating Patients With Advanced Anaplastic Thyroid Cancer
Case Comprehensive Cancer Center
NCT00060242
Topical Antisepsis in Head and Neck Cancer Surgery
Medical College of Wisconsin
NCT04721626
Mirror Grant - Toward an Understanding of Body Image Adaptation Following Surgical Treatment for Head and Neck Cancer
M.D. Anderson Cancer Center
NCT01432132
Growth Factor Levels in the Blood of Patients Undergoing Radiation Therapy for Epithelial Cancer
Vanderbilt-Ingram Cancer Center
NCT00897793
Celecoxib in Treating Patients With Progressive Metastatic Differentiated Thyroid Cancer
Ohio State University Comprehensive Cancer Center
NCT00061906
A Pilot Trial of Image-Guided Adaptive Radiotherapy for Head and Neck Cancer
M.D. Anderson Cancer Center
NCT00490282
T-Lymphocytes in Treating Patients With Epstein-Barr Virus-Positive Nasopharyngeal Cancer, NPC
Baylor College of Medicine
NCT00609219
Local Infusion of Ropivacaine for Post-Op Pain Control After Osseocutaneous Free Flaps
Icahn School of Medicine at Mount Sinai
NCT03349034
Skin Rash Study Before Chemotherapy in Colorectal & Head and Neck Cancer Patients
University of Louisville
NCT01874860
Pain Management Smartphone Application for Patients With Stage III-IV Head and Neck Cancer Undergoing Radiation Therapy
Vanderbilt-Ingram Cancer Center
NCT02324881
A Study Using Cone Beam CT for Head and Neck Cancer
University of Michigan Rogel Cancer Center
NCT01661062
Celecoxib in Preventing Cancer in Patients With Oral Leukoplakia and/or Head and Neck Dysplasia
Dana-Farber Cancer Institute
NCT00052611
Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma
Washington University School of Medicine
NCT05678348
Cisplatin Plus Gemcitabine in Treating Patients With Advanced Squamous Cell Head and Neck Cancer
Fox Chase Cancer Center
NCT00003264
Chemotherapy Plus Radiation Therapy in Treating Patients With Squamous Cell Cancer of the Head and Neck
Dana-Farber Cancer Institute
NCT00003200
Lapatinib and Cetuximab in Patients With Solid Tumors
Georgetown University
NCT01184482
Study of Personalized Sterile Humidification Device for Mucositis in Head and Neck Cancer Patients
University of California, San Francisco
NCT01930435
A Study Comparing Oral Picoplatin With Intravenous Picoplatin in Subjects With Solid Tumors
Poniard Pharmaceuticals
NCT00465725
Sorafenib, Pemetrexed, and Cisplatin in Treating Patients With Advanced Solid Tumors
Masonic Cancer Center, University of Minnesota
NCT00703638
Comprehensive Assessment of Head and Neck Cancer Survivors
Jay F. Piccirillo, MD
NCT01222481
Intratumoral Microdosing of TAK-981 in Head and Neck Cancer
Presage Biosciences
NCT04065555
Phase I Study of CUDC-101 With Cisplatin and Radiation in Subjects With Head & Neck Cancer
Curis
NCT01384799
Pilot Study of AuroLase(tm) Therapy in Refractory and/or Recurrent Tumors of the Head and Neck
Nanospectra Biosciences
NCT00848042
Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer
University of California, San Diego
NCT03993353
Surgery With or Without Adjuvant Stereotactic Body Radiotherapy
David A. Clump, MD, PhD
NCT02516969
Radiation and Cetuximab Plus Intratumoral EGFR Antisense DNA in Locally Advanced Head and Neck Squamous Cell Carcinoma
The University of Texas Health Science Center at San Antonio
NCT01592721
Study of ABT-510 (Thrombospondin Analogue) in Patients With Advanced Head and Neck Cancer
M.D. Anderson Cancer Center
NCT00113334
Pilot Study of Raltegravir and Cisplatin in Squamous Cell Carcinoma of Head and Neck
New Mexico Cancer Research Alliance
NCT01275183
MRI Mapping in Planning Radiation Therapy to the Base of Skull and Brain in Patients With Nonmetastatic Head and Neck Cancer
Abramson Cancer Center at Penn Medicine
NCT00984074
Capecitabine For Nasopharyngeal Cancer
Dana-Farber Cancer Institute
NCT00095901
Finding Predictors of Side Effects to Chemoradiation Treatment in Elderly Patients With Head and Neck Cancer
UNC Lineberger Comprehensive Cancer Center
NCT01688323
Detection of Cervical Lymph Node Metastases With a High-Resolution Positron Emission Tomography (PET) Imaging System
M.D. Anderson Cancer Center
NCT01030497
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 63 |
| Phase 2 | 74 |
| Phase 3 | 11 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Head and Neck Cancer Trial Landscape
260 indexed Head and Neck Cancer studies · 89 recruiting (34%).
Phase mix: 13 late (III/IV) vs 137 early (I/II).
Top sponsor: M.D. Anderson Cancer Center (19 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Head and Neck Cancer?
PlainTrial tracks 260 US clinical trials for Head and Neck Cancer, of which 89 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Head and Neck Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.