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Head and Neck Cancer clinical trials
89 of 260 indexed Head and Neck Cancer trials are currently recruiting.
260 US clinical trials · 89 currently recruiting
Head and Neck Cancer is the subject of 260 registered US clinical trials on ClinicalTrials.gov, 89 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 137 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 19 of these trials.
The research picture
Head and Neck Cancer has 260 registered US clinical trials, 89 of them open to new participants right now, about 34% of the total.
- 89
- recruiting participants now
- 34%
- of trials open to enrollment
- 13
- in Phase 3–4 (later-stage)
- 19
- top sponsor: M.D. Anderson Cancer Center
Active & Recent Trials
260 total, page 4 of 6
Hypofractionated Preoperative Radiation for Head and Neck Cancers (HyPR-HN)
Medical College of Wisconsin
NCT05538533
Imaging With a PET Agent for Detection of Cancers of the Head and Neck
Memorial Sloan Kettering Cancer Center
NCT03631017
ASP-1929 Photoimmunotherapy (PIT) Study in Patients With Recurrent Head/Neck Cancer
Rakuten Medical
NCT05182866
Trial of Ibrutinib Combined With Nivolumab or Cetuximab to Treat Recurrent/Metastatic HNSCC
University of California, San Diego
NCT03646461
A Study of Xevinapant With Cisplatin and Radiation Therapy After Surgery in People With Head and Neck Cancer
Memorial Sloan Kettering Cancer Center
NCT06145412
Creation of the BioBank, Early Detection and Discovery Biomarkers
Corewell Health East
NCT00901680
PRospective REgistry of Advanced Stage CancER (PREFER) Patients to Assess Prevalence of Actionable Biomarkers and Driver Mutations to Address Disparities in Precision Medicine
Labcorp Corporation of America Holdings
NCT05697198
Effectiveness of Lay Navigators in Meeting Cancer Patients' Non-Clinical Needs: A Pilot Study
Stanford University
NCT03245788
Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer
Radiation Therapy Oncology Group
NCT01302834
Chemotherapy and Radiation Therapy With or Without Surgery in Treating Patients With Head and Neck Cancer
Radiation Therapy Oncology Group
NCT00047008
Blood Proteins in Predicting Treatment Benefit in Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer
Vanderbilt-Ingram Cancer Center
NCT00896675
Study of Cabiralizumab in Combination With Nivolumab in Patients With Selected Advanced Cancers
Five Prime Therapeutics
NCT02526017
Sexual Behavior in Oropharyngeal Patients Versus Head and Neck Cancer Patients, With or Without HPV Infection
M.D. Anderson Cancer Center
NCT00508170
Enhanced Care Coordination for Head and Neck Cancer Survivors
University of Pittsburgh
NCT04813172
Reliability and Validity of Patient Reported Outcome Measures in Head and Neck Cancer
Mayo Clinic
NCT02554968
Combination Chemotherapy and Radiation in Treating Patients With Stage III or IV Head and Neck Cancer (Paradigm Trial)
Dana-Farber Cancer Institute
NCT00095875
Fruit and Vegetable Extracts in Treating Patients With Stage I-IV, Stage IVA/IVB Head and Neck Cancer
Wake Forest University Health Sciences
NCT00064298
Perioperative Gabapentin Use In Head And Neck Mucosal Surgery Patients
Washington University School of Medicine
NCT02926573
A Study of MEHD7945A Versus Cetuximab in Patients With Recurrent/Metastatic Squamous Cell Carcinoma of The Head And Neck
Genentech
NCT01577173
Use of a Non-ICU Specialty Ward For Immediate Post-operative Management of Head and Neck Free Flaps
University of California, Davis
NCT03340038
Docetaxel in Treating Patients With Solid Tumors
Alliance for Clinical Trials in Oncology
NCT00003565
Optimization of Smoking Cessation Strategies Concurrent With Treatment of Tobacco Related Malignancies
University of Kentucky
NCT02048917
Pharmacogenomic Study in Patients of Lung, Colorectal and Head/Neck Cancers Receiving Chemotherapy
University of Kansas Medical Center
NCT00442520
Trial of Induction Chemotherapy With Carboplatin and Paclitaxel, Followed by Concurrent Chemotherapy/Radiation Therapy With ZD1839 (IRESSA), 5-FU, Hydroxyurea, and Twice-Daily Radiation, Followed by Adjuvant ZD1839 Monotherapy in Patients With Locally Advanced Head & Neck Cancer
University of Chicago
NCT01185171
Reproducibility of 18F Uptake by Solid Tumors Using PET Imaging Following Intravenous Administration of (18F) Injection
GE Healthcare
NCT00918281
Chemotherapy and Radiation Therapy Following Surgery in Treating Patients With Head and Neck Cancer
Radiation Therapy Oncology Group
NCT00011999
Validity and Reliability of Outcome Measures in Patients With Cancer of the Head and Neck
Mayo Clinic
NCT01952821
Feasibility Study of the Head and Neck Survivorship Tool: Assessment and Recommendations (HN-STAR)
Memorial Sloan Kettering Cancer Center
NCT02571673
Adaptive Radiotherapy for Head and Neck Cancer
Memorial Sloan Kettering Cancer Center
NCT03096808
Cisplatin and Radiation Therapy in Treating Patients With Stage IV Cancer of the Head and Neck
Radiation Therapy Oncology Group
NCT00002932
2 Phase Use Of Educational Materials In Head And Neck Cancer Center
Massachusetts General Hospital
NCT02204631
Nutrition and Resistance Training in Head and Neck Cancer
Vanderbilt University
NCT00696553
Pembrolizumab in Combination With CRT for LA-SCCHN
Sanford Health
NCT02586207
Study of Chemotherapy With Cisplatin/Carboplatin, and Docetaxel With or Without Erlotinib in Patients With Head and Neck Squamous Cell Carcinomas Amenable for Surgical Resection
M.D. Anderson Cancer Center
NCT01927744
Low-Cost, Portable Flexible Nasopharyngoscope in Head & Neck Cancers in Low Resource Settings - Optimization Phase
Duke University
NCT04905134
A Study to Evaluate NT219 Alone and in Combination with ERBITUX® (Cetuximab) in Adults with Advanced Solid Tumors and Head and Neck Cancer
TyrNovo
NCT04474470
Imaging Study on Halcyon 4.0 System for Patients Receiving Radiation Therapy
Washington University School of Medicine
NCT05427214
Cross-Sectional Study of Oral Health in Patients After Parotid-Sparing Radiation Therapy for Head and Neck Cancer
University of Michigan Rogel Cancer Center
NCT01663246
Carboplatin, Capecitabine, and Radiation Therapy in Treating Patients With Stage III or Stage IV Head and Neck Cancer
University of Virginia
NCT00114153
Dentures and Dental Implants in Treating Patients Undergoing Surgery for Mouth Cancer
Jonsson Comprehensive Cancer Center
NCT00006341
LYT-200 Alone and in Combination With Chemotherapy or Tislelizumab in Patients With Locally Advanced or Metastatic Solid Tumors
PureTech
NCT04666688
Study of the CD40 Agonistic Monoclonal Antibody APX005M
Apexigen America
NCT02482168
Multimodality Risk Adapted Tx Including Induction Chemo for SCCHN Amenable to Transoral Surgery
UNC Lineberger Comprehensive Cancer Center
NCT01612351
Functional Sparing of Salivary Glands Using MRI Sialography for Patients Undergoing Definitive Radiation Therapy for Head and Neck Cancers of the Oropharynx
UNC Lineberger Comprehensive Cancer Center
NCT03418792
L-778,123 in Treating Patients With Recurrent or Refractory Solid Tumors
Memorial Sloan Kettering Cancer Center
NCT00003430
Biopsy of Human Tumors for Cancer Stem Cell Characterization: a Feasibility Study
Stanford University
NCT00610415
Phase IB Study Using Sunitinib Plus Radiation Therapy for Cancer Patients
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT00437372
A First in Human, Dose Escalation Study of JAB-3068 (SHP2 Inhibitor) in Adult Patients With Advanced Solid Tumors
Jacobio Pharmaceuticals Co.
NCT03518554
Zileuton in Preventing Lung Cancer in Patients With Bronchial Dysplasia
Barbara Ann Karmanos Cancer Institute
NCT00056004
Paclitaxel and Radiation Therapy Plus Chemoprotection With Amifostine in Treating Patients With Stage III or Stage IV Head and Neck Cancer
Massachusetts General Hospital
NCT00003193
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 63 |
| Phase 2 | 74 |
| Phase 3 | 11 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Head and Neck Cancer Trial Landscape
260 indexed Head and Neck Cancer studies · 89 recruiting (34%).
Phase mix: 13 late (III/IV) vs 137 early (I/II).
Top sponsor: M.D. Anderson Cancer Center (19 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Head and Neck Cancer?
PlainTrial tracks 260 US clinical trials for Head and Neck Cancer, of which 89 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Head and Neck Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.