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ClinicalTrials.gov 78 recruiting now official registry

Glioblastoma clinical trials

78 of 200 indexed Glioblastoma trials are currently recruiting.

200 US clinical trials · 78 currently recruiting

Glioblastoma is the subject of 200 registered US clinical trials on ClinicalTrials.gov, 78 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 148 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 10 of these trials.

The research picture

Glioblastoma has 200 registered US clinical trials, 78 of them open to new participants right now, about 39% of the total.

78
recruiting participants now
39%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
10
top sponsor: National Cancer Institute (NCI)
Phase 187Phase 261Phase 313Phase 42

Active & Recent Trials

200 total, page 2 of 4

RECRUITING NA 30 participants

Evaluation of the CONVIVO System

Dartmouth-Hitchcock Medical Center

NCT05139277

RECRUITING Phase 2 30 participants

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

Memorial Sloan Kettering Cancer Center

NCT06058988

RECRUITING Phase 1 30 participants

Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas

SignPath Pharma

NCT05768919

RECRUITING Phase 1 29 participants

Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma

M.D. Anderson Cancer Center

NCT04555577

RECRUITING Early Phase 1 27 participants

A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma

Ugonma Chukwueke

NCT06552260

RECRUITING NA 25 participants

Glioblastoma Remote Monitoring and Care - Research Protocol

Case Comprehensive Cancer Center

NCT06129760

RECRUITING Phase 2 25 participants

Investigator-Initiated Study of Imipramine Hydrochloride and Lomustine in Recurrent Glioblastoma

The University of Texas Health Science Center at San Antonio

NCT04863950

RECRUITING Phase 1 24 participants

A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma

University of Nebraska

NCT05698524

RECRUITING Phase 1 24 participants

Verteporfin for the Treatment of Recurrent High Grade EGFR-Mutated Glioblastoma

Emory University

NCT04590664

RECRUITING Phase 1 21 participants

CARv3-TEAM-E T Cells in Glioblastoma

Marcela V. Maus, M.D.,Ph.D.

NCT05660369

RECRUITING 20 participants

NovoTTF Treatment Signatures in Glioblastoma Patients At Autopsy

Medical College of Wisconsin

NCT03194971

RECRUITING NA 20 participants

Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma

Columbia University

NCT06108206

RECRUITING Phase 1 20 participants

Laser Interstitial Thermal Therapy (LITT) and Lomustine (CCNU) for Recurrent Glioblastoma

University of California, Davis

NCT07145112

RECRUITING Phase 1 20 participants

Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

Sabine Mueller, MD, PhD

NCT04323046

RECRUITING Phase 1 20 participants

Anti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T Cells

Hideho Okada, MD, PhD

NCT06186401

RECRUITING Phase 2 19 participants

Methimazole in Patients With Progressive Glioblastoma

Case Comprehensive Cancer Center

NCT05607407

RECRUITING Phase 1 18 participants

CUE-102 in Recurrent Glioblastoma

David Reardon, MD

NCT06917885

RECRUITING Phase 1 18 participants

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Henry Ford Health System

NCT05686798

RECRUITING Phase 1 18 participants

PH Sensitive MRI Based Resections of Glioblastoma

University of California, Los Angeles

NCT06176066

RECRUITING Early Phase 1 15 participants

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Nationwide Children's Hospital

NCT06333899

RECRUITING Phase 3 15 participants

Advanced Imaging Techniques for Evaluating the Tumor Immune Microenvironment in Glioblastoma Patients

Jonsson Comprehensive Cancer Center

NCT07461948

RECRUITING Early Phase 1 15 participants

Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma

Abramson Cancer Center at Penn Medicine

NCT06613841

RECRUITING Early Phase 1 12 participants

Implantable Microdevice In Primary Brain Tumors

Oliver Jonas

NCT04135807

RECRUITING Early Phase 1 12 participants

Neoadjuvant Chemoradiotherapy With or Without Concurrent Azeliragon in Patients With Newly Diagnosed Glioblastoma

Washington University School of Medicine

NCT06831526

RECRUITING Early Phase 1 12 participants

Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG

Nader Sanai

NCT05773326

RECRUITING NA 10 participants

Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)

Northwell Health

NCT05979064

RECRUITING Phase 1 10 participants

Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression

Case Comprehensive Cancer Center

NCT05565118

RECRUITING Phase 1 9 participants

CART-EGFR-IL13Ra2 in Newly Diagnosed GBM Following Initial Radiotherapy

University of Pennsylvania

NCT06973096

ACTIVE NOT RECRUITING Phase 2 606 participants

Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

NRG Oncology

NCT02179086

ACTIVE NOT RECRUITING Phase 3 560 participants

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

CarThera

NCT05902169

ACTIVE NOT RECRUITING Phase 2 447 participants

Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

National Cancer Institute (NCI)

NCT02152982

ACTIVE NOT RECRUITING Phase 3 314 participants

Intraoperative Radiotherapy in Newly Diagnosed Glioblastoma Multiforme

Universitätsmedizin Mannheim

NCT02685605

ACTIVE NOT RECRUITING 309 participants

Coping With Glioblastoma: A Study of Communication Between Physicians, Patients, and Caregivers

Memorial Sloan Kettering Cancer Center

NCT02375841

ACTIVE NOT RECRUITING Phase 3 265 participants

Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma

NRG Oncology

NCT05095376

ACTIVE NOT RECRUITING Phase 1 179 participants

Study of NGM707 As Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

NGM Biopharmaceuticals

NCT04913337

ACTIVE NOT RECRUITING Phase 2 170 participants

Short Course Radiotherapy for the Treatment of Patients With Glioblastoma, SAGA Study

Mayo Clinic

NCT05781321

ACTIVE NOT RECRUITING Phase 4 163 participants

Pediatric Long-Term Follow-up and Rollover Study

Novartis Pharmaceuticals

NCT03975829

ACTIVE NOT RECRUITING Phase 1 150 participants

Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma

Nerviano Medical Sciences

NCT04910022

ACTIVE NOT RECRUITING Phase 2 130 participants

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG

Theodore S. Johnson

NCT04049669

ACTIVE NOT RECRUITING Phase 1 125 participants

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Sapience Therapeutics

NCT04478279

ACTIVE NOT RECRUITING NA 100 participants

Intensity-Modulated Stereotactic Radiation Therapy in Treating Patients With Grade II-IV Glioma

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT03251027

ACTIVE NOT RECRUITING Early Phase 1 97 participants

AZD1390 in Recurrent and Newly Diagnosed WHO Grade 4 Glioma Patients

Nader Sanai

NCT05182905

ACTIVE NOT RECRUITING Phase 2 93 participants

A Phase 2b Clinical Study With a Combination Immunotherapy in Newly Diagnosed Patients With Glioblastoma

Imvax

NCT04485949

ACTIVE NOT RECRUITING Phase 2 90 participants

Nivolumab Plus Standard Dose Bevacizumab Versus Nivolumab Plus Low Dose Bevacizumab in GBM

David Peereboom

NCT03452579

ACTIVE NOT RECRUITING Phase 2 89 participants

Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations

National Cancer Institute (NCI)

NCT03212274

ACTIVE NOT RECRUITING Phase 2 84 participants

ERC1671/GM-CSF/Cyclophosphamide for the Treatment of Glioblastoma Multiforme

Epitopoietic Research Corporation

NCT01903330

ACTIVE NOT RECRUITING Phase 1 78 participants

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

University of California, San Francisco

NCT03749187

ACTIVE NOT RECRUITING NA 74 participants

Mind-Body Intervention in Glioma Couples

M.D. Anderson Cancer Center

NCT03244995

ACTIVE NOT RECRUITING Phase 1 67 participants

CART-EGFR-IL13Ra2 in EGFR Amplified Recurrent GBM

University of Pennsylvania

NCT05168423

ACTIVE NOT RECRUITING Phase 2 66 participants

SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Roswell Park Cancer Institute

NCT02455557

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Phase Distribution

PhaseTrial count
Phase 1 87
Phase 2 61
Phase 3 13
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Glioblastoma Trial Landscape

200 indexed Glioblastoma studies · 78 recruiting (39%).

Phase mix: 15 late (III/IV) vs 148 early (I/II).

Top sponsor: National Cancer Institute (NCI) (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Glioblastoma?

PlainTrial tracks 200 US clinical trials for Glioblastoma, of which 78 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Glioblastoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.