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NCT04555577 · ClinicalTrials.gov registry record · Phase 1
Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma
A Phase 1 study of Glioblastoma and Gliosarcoma, sponsored by M.D. Anderson Cancer Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 29
- Enrollment target
- 1
- Study location
NCT04555577: Recruiting Phase 1 study of Glioblastoma and Gliosarcoma, sponsored by M.D. Anderson Cancer Center.
NCT04555577 is a Phase 1 study of Glioblastoma and Gliosarcoma that is actively recruiting participants, run by M.D. Anderson Cancer Center. The registered enrollment target is 29 participants, below the 109-participant average among 199 other Glioblastoma trials with a reported enrollment target (73% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04555577, a Phase 1 study of Glioblastoma and Gliosarcoma, is actively recruiting participants, sponsored by M.D. Anderson Cancer Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 29 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase I trial investigates the side effects and best dose of Peposertib, and to see how well it works in combination with radiation therapy in treating patients with newly diagnosed MGMT unmethylated glioblastoma or gliosarcoma. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Peposertib may further stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Chemotherapy drugs, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving Peposertib with radiation therapy may work better than radiation therapy alone in treating patients with glioblastoma or gliosarcoma.
Primary Outcome
Will employ the Bayesian optimal interval to find the MTD.
Conditions Studied
Interventions
- RADIATION Radiation Therapy
- DRUG Temozolomide
- PROCEDURE Resection
- DRUG Peposertib
Study Locations (1)
Texas
- M D Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2020-09-20 |
| Est. Completion | 2027-12-31 |
| Phase | Phase 1 |
What NCT04555577 shows while recruiting
NCT04555577 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 29 participants, a relatively small participant target, below the 109-participant average among 199 other Glioblastoma trials with a reported enrollment target (73% lower).
The record links to 2 conditions, with Glioblastoma appearing as the primary indexed condition, and to 4 interventions - of which Radiation Therapy is the first listed.
NCT04555577 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT04555577 about?
NCT04555577 is a clinical study titled "Peposertib and Radiation Therapy, Followed by Temozolomide for the Treatment of Patients With Newly Diagnosed MGMT Unmethylated Glioblastoma or Gliosarcoma". This phase I trial investigates the side effects and best dose of Peposertib, and to see how well it works in combination with radiation therapy in treating patients with newly diagnosed MGMT unmethylated glioblastoma or gliosarcoma. Radiation therapy uses high energy x-rays to kill tumor cells and ...
What is the current status of trial NCT04555577?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 29 participants. The study started on 2020-09-20. Estimated completion is 2027-12-31.
What conditions does trial NCT04555577 study?
This clinical trial studies the following conditions: Glioblastoma, Gliosarcoma.
What interventions are being tested in trial NCT04555577?
The interventions under investigation include: Radiation Therapy (RADIATION), Temozolomide (DRUG), Resection (PROCEDURE), Peposertib (DRUG).
Who is sponsoring clinical trial NCT04555577?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04555577 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Glioblastoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04555577's enrollment target sits among peer trials
29 132nd of 199 higher than 67 of 199 other Glioblastoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Glioblastoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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