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ClinicalTrials.gov 78 recruiting now official registry

Glioblastoma clinical trials

78 of 200 indexed Glioblastoma trials are currently recruiting.

200 US clinical trials · 78 currently recruiting

Glioblastoma is the subject of 200 registered US clinical trials on ClinicalTrials.gov, 78 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 148 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 10 of these trials.

The research picture

Glioblastoma has 200 registered US clinical trials, 78 of them open to new participants right now, about 39% of the total.

78
recruiting participants now
39%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
10
top sponsor: National Cancer Institute (NCI)
Phase 187Phase 261Phase 313Phase 42

Active & Recent Trials

200 total, page 3 of 4

ACTIVE NOT RECRUITING Phase 1 65 participants

A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.

Novartis Pharmaceuticals

NCT05109728

ACTIVE NOT RECRUITING Phase 1 63 participants

Surgical Nivolumab And Ipilimumab For Recurrent GBM

Patrick Wen, MD

NCT04606316

ACTIVE NOT RECRUITING Phase 2 62 participants

Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype

National Cancer Institute (NCI)

NCT03718767

ACTIVE NOT RECRUITING Phase 4 61 participants

GammaTile and Stupp in Newly Diagnosed GBM

GT Medical Technologies

NCT05342883

ACTIVE NOT RECRUITING Phase 1 60 participants

Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma

Case Comprehensive Cancer Center

NCT03514069

ACTIVE NOT RECRUITING Phase 1 60 participants

Mycophenolate Mofetil in Combination With Standard of Care for the Treatment of Glioblastoma

Northwestern University

NCT05236036

ACTIVE NOT RECRUITING 60 participants

Assessment of Optune Therapy for Patients With Newly Diagnosed Glioblastoma Using Advanced MRI

Medical College of Wisconsin

NCT03297125

ACTIVE NOT RECRUITING Phase 2 58 participants

Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

National Cancer Institute (NCI)

NCT03919071

ACTIVE NOT RECRUITING Phase 1 57 participants

Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma

Northwestern University

NCT04528680

ACTIVE NOT RECRUITING Phase 1 52 participants

INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)

Inovio Pharmaceuticals

NCT03491683

ACTIVE NOT RECRUITING Phase 2 52 participants

Pembrolizumab and Standard Therapy in Treating Patients With Glioblastoma

Mayo Clinic

NCT03197506

ACTIVE NOT RECRUITING Phase 2 50 participants

A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastoma (GB)

BPGbio

NCT04752813

ACTIVE NOT RECRUITING Phase 2 48 participants

Clindamycin and Triamcinolone in People With Glioblastoma to Prevent Skin-Related Side Effects of Tumor Treating Fields

Memorial Sloan Kettering Cancer Center

NCT04469075

ACTIVE NOT RECRUITING Phase 2 47 participants

Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

National Cancer Institute (NCI)

NCT04817254

ACTIVE NOT RECRUITING Early Phase 1 46 participants

AB154 Combined With AB122 for Recurrent Glioblastoma

Yale University

NCT04656535

ACTIVE NOT RECRUITING Phase 2 45 participants

A Study of Abemaciclib in Recurrent Glioblastoma

Dana-Farber Cancer Institute

NCT02981940

ACTIVE NOT RECRUITING Early Phase 1 45 participants

Study of Pamiparib in Newly Diagnosed and rGBM

Nader Sanai

NCT04614909

ACTIVE NOT RECRUITING NA 44 participants

Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma

University of California, San Francisco

NCT03739372

ACTIVE NOT RECRUITING Phase 2 43 participants

DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab

Annick Desjardins, MD

NCT03688178

ACTIVE NOT RECRUITING Early Phase 1 42 participants

Trial of Niraparib in Participants With Newly-diagnosed Glioblastoma and Recurrent Glioma

Nader Sanai

NCT05076513

ACTIVE NOT RECRUITING Phase 2 40 participants

Study Testing The Safety and Efficacy of Adjuvant Temozolomide Plus TTFields (Optune®) Plus Pembrolizumab in Patients With Newly Diagnosed Glioblastoma (2-THE-TOP)

University of Florida

NCT03405792

ACTIVE NOT RECRUITING Phase 2 39 participants

Anti-GITR/Anti-PD1/Stereotactic Radiosurgery, in Recurrent Glioblastoma

University of Pennsylvania

NCT04225039

ACTIVE NOT RECRUITING Phase 1 39 participants

IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma

University of Florida

NCT05353530

ACTIVE NOT RECRUITING Phase 2 39 participants

Nivolumab With Radiation Therapy and Bevacizumab for Recurrent MGMT Methylated Glioblastoma

Memorial Sloan Kettering Cancer Center

NCT03743662

ACTIVE NOT RECRUITING Phase 2 38 participants

Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

National Cancer Institute (NCI)

NCT03581292

ACTIVE NOT RECRUITING Phase 2 38 participants

Analyzing Pulsed Reduced Dose Radiotherapy in Upfront Glioblastoma

Medical College of Wisconsin

NCT04747145

ACTIVE NOT RECRUITING Phase 1 36 participants

Ibrutinib With Radiation and Temozolomide in Patients With Newly Diagnosed Glioblastoma

Case Comprehensive Cancer Center

NCT03535350

ACTIVE NOT RECRUITING Phase 2 30 participants

Azeliragon in MGMT Unmethylated Glioblastoma

Cantex Pharmaceuticals

NCT05986851

ACTIVE NOT RECRUITING Phase 2 30 participants

Niraparib/TTFields in GBM

Abramson Cancer Center at Penn Medicine

NCT04221503

ACTIVE NOT RECRUITING Phase 2 30 participants

Multiparametric MR-Guided High Dose Adaptive Radiotherapy With Concurrent Temozolomide in Patients With Newly Diagnosed Glioblastoma

University of Michigan Rogel Cancer Center

NCT04574856

ACTIVE NOT RECRUITING Phase 1 29 participants

Memory-Enriched T Cells in Treating Patients With Recurrent or Refractory Grade III-IV Glioma

City of Hope Medical Center

NCT03389230

ACTIVE NOT RECRUITING Phase 1 27 participants

OKN-007 in Combination With Adjuvant Temozolomide Chemoradiotherapy for Newly Diagnosed Glioblastoma

University of Oklahoma

NCT03587038

ACTIVE NOT RECRUITING Phase 1 26 participants

Oral Gallium Maltolate for the Treatment of Relapsed and Refractory Glioblastoma

Medical College of Wisconsin

NCT04319276

ACTIVE NOT RECRUITING Phase 1 21 participants

Ketogenic Diet in Combination With Standard-of-care Radiation and Temozolomide for Patients With Glioblastoma

Jethro Hu

NCT03451799

ACTIVE NOT RECRUITING NA 20 participants

Personalized Radiation Therapy for GBM

Abramson Cancer Center at Penn Medicine

NCT03477513

ACTIVE NOT RECRUITING Phase 1 18 participants

Nivolumab, BMS-986205, and Radiation Therapy With or Without Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

Northwestern University

NCT04047706

ACTIVE NOT RECRUITING Phase 1 18 participants

A Study Using Radiation Therapy and Temozolomide to Treat Glioblastoma in Patients Over 70

University of Louisville

NCT01985087

ACTIVE NOT RECRUITING NA 18 participants

Improving Understanding of Brain Tumors Through Preservation of Biologically Active Brain Tissue

Case Comprehensive Cancer Center

NCT04545177

ACTIVE NOT RECRUITING Phase 2 18 participants

A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging

Weill Medical College of Cornell University

NCT04691960

ACTIVE NOT RECRUITING Phase 1 17 participants

A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma

Bryan Allen

NCT04900792

ACTIVE NOT RECRUITING Phase 3 17 participants

Tofacitinib in Recurrent GBM Patients

University of Texas Southwestern Medical Center

NCT05326464

ACTIVE NOT RECRUITING Phase 1 16 participants

Radiation/Temozolomide and Immunotherapy With Daratumumab to Improve Antitumor Efficacy in Glioblastoma

West Virginia University

NCT04922723

ACTIVE NOT RECRUITING NA 16 participants

Pilot Study of a Metabolic Nutritional Therapy for the Management of Primary Brain Tumors

Michigan State University

NCT01535911

ACTIVE NOT RECRUITING Early Phase 1 14 participants

Identification of Treatment Concentrations of Defactinib or VS-6766 for the Treatment of Patients With Glioblastoma

Emory University

NCT05798507

ACTIVE NOT RECRUITING Phase 1 13 participants

Safety and Immunogenicity of Personalized Genomic Vaccine and Tumor Treating Fields (TTFields) to Treat Glioblastoma

Adilia Hormigo

NCT03223103

ACTIVE NOT RECRUITING NA 12 participants

Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM

Northwell Health

NCT03630289

ACTIVE NOT RECRUITING Phase 1 12 participants

A Phase IB 2 Dose Trial of IRS-1 HSV C134 (IND 17296) Administered Intratumorally in Patients With Recurrent Malignant Glioma

James Markert, MD

NCT06614855

ACTIVE NOT RECRUITING Phase 1 11 participants

Selinexor (KPT-330) in Combination With Temozolomide and Radiation Therapy in Patients With Newly Diagnosed Glioblastoma

National Cancer Institute (NCI)

NCT04216329

ACTIVE NOT RECRUITING Phase 1 10 participants

Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma

City of Hope Medical Center

NCT04661384

ACTIVE NOT RECRUITING Phase 1 10 participants

Study to Evaluate the Safety, Tolerability, Immunogenicity and Preliminary Efficacy of ITI-1001 In Patients With Newly Diagnosed Glioblastoma (GBM)

Immunomic Therapeutics

NCT05698199

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Phase Distribution

PhaseTrial count
Phase 1 87
Phase 2 61
Phase 3 13
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Glioblastoma Trial Landscape

200 indexed Glioblastoma studies · 78 recruiting (39%).

Phase mix: 15 late (III/IV) vs 148 early (I/II).

Top sponsor: National Cancer Institute (NCI) (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Glioblastoma?

PlainTrial tracks 200 US clinical trials for Glioblastoma, of which 78 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Glioblastoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.