Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 2

SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

NCT02455557 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial studies the side effects and how well vaccine therapy works when given together with temozolomide in treating patients with newly diagnosed glioblastoma. Vaccines made from the survivin peptide or antigen may help the body build an effective immune response to kill tumor cells that express survivin. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether temozolomide is more effective with or without vaccine therapy in treating glioblastoma.

Conditions Studied

Interventions

  • OTHER Laboratory Biomarker Analysis
  • DRUG Temozolomide
  • BIOLOGICAL Sargramostim
  • BIOLOGICAL SVN53-67/M57-KLH Peptide Vaccine
  • DRUG Montanide ISA 51 VG

Study Locations (5)

Massachusetts

  • Massachusetts General Hospital Cancer Center — Boston
  • Dana-Farber Harvard Cancer Center — Boston
  • Beth Israel Deaconess Medical Center — Boston

New York

  • Roswell Park Cancer Institute — Buffalo

Ohio

  • Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center — Cleveland

Trial Details

FieldValue
Enrollment Target 66 participants
Start Date 2015-05-04
Est. Completion 2026-03-02
Phase Phase 2

Sponsor

Roswell Park Cancer Institute

228 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02455557

The ClinicalTrials.gov registry entry for NCT02455557 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 66 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Roswell Park Cancer Institute, which has 228 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Glioblastoma appearing as the primary indexed condition, and to 5 interventions — of which Laboratory Biomarker Analysis is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02455557 reports 5 study locations spanning 3 distinct geographic areas — top geographies include Massachusetts, New York, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02455557 about?

NCT02455557 is a clinical study titled "SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma". This phase II trial studies the side effects and how well vaccine therapy works when given together with temozolomide in treating patients with newly diagnosed glioblastoma. Vaccines made from the survivin peptide or antigen may help the body build an effective immune response to kill tumor cells th...

What is the current status of trial NCT02455557?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 66 participants. The study started on 2015-05-04. Estimated completion is 2026-03-02.

What conditions does trial NCT02455557 study?

This clinical trial studies the following conditions: Glioblastoma, Gliosarcoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02455557?

The interventions under investigation include: Laboratory Biomarker Analysis (OTHER), Temozolomide (DRUG), Sargramostim (BIOLOGICAL), SVN53-67/M57-KLH Peptide Vaccine (BIOLOGICAL), Montanide ISA 51 VG (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02455557?

This trial is sponsored by Roswell Park Cancer Institute, which has 228 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02455557 being conducted?

This trial has 5 study locations across Massachusetts, New York, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial