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ERC1671/GM-CSF/Cyclophosphamide for the Treatment of Glioblastoma Multiforme
NCT01903330 · View on ClinicalTrials.gov ↗
Study Summary
This phase II clinical trial studies how well ERC1671 plus Granulocyte-macrophage colony-stimulating factor (GM-CSF) plus Cyclophosphamide with Bevacizumab works compared to Placebo Injection plus Placebo Pill with Bevacizumab in treating patients with recurrent/progressive, bevacizumab naïve glioblastoma multiforme and gliosarcoma (World Health Organization (WHO) grade IV malignant gliomas, GBM).
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG GM-CSF
- DRUG ERC1671
- DRUG Oral Control (Sucrose pill)
- DRUG Injectable control (Sodium Chloride Injection United States Pharmacopeia (USP) (0.9%))
Study Locations (3)
Massachusetts
- Massachusetts General Hospital Cancer Center — Boston
- Dana Farber Cancer Institute — Boston
California
- University of California, Irvine — Orange
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 84 participants |
| Start Date | 2014-03 |
| Est. Completion | 2026-06 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01903330
The ClinicalTrials.gov registry entry for NCT01903330 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 84 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Epitopoietic Research Corporation, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Glioblastoma appearing as the primary indexed condition, and to 5 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT01903330 reports 3 study locations spanning 2 distinct geographic areas — top geographies include Massachusetts, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT01903330 about?
NCT01903330 is a clinical study titled "ERC1671/GM-CSF/Cyclophosphamide for the Treatment of Glioblastoma Multiforme". This phase II clinical trial studies how well ERC1671 plus Granulocyte-macrophage colony-stimulating factor (GM-CSF) plus Cyclophosphamide with Bevacizumab works compared to Placebo Injection plus Placebo Pill with Bevacizumab in treating patients with recurrent/progressive, bevacizumab naïve gliobl...
What is the current status of trial NCT01903330?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 84 participants. The study started on 2014-03. Estimated completion is 2026-06.
What conditions does trial NCT01903330 study?
This clinical trial studies the following conditions: Glioblastoma, Gliosarcoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT01903330?
The interventions under investigation include: Cyclophosphamide (DRUG), GM-CSF (DRUG), ERC1671 (DRUG), Oral Control (Sucrose pill) (DRUG), Injectable control (Sodium Chloride Injection United States Pharmacopeia (USP) (0.9%)) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT01903330?
This trial is sponsored by Epitopoietic Research Corporation, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT01903330 being conducted?
This trial has 3 study locations across California, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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