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ClinicalTrials.gov 14 recruiting now official registry

Chronic Myeloid Leukemia clinical trials

Every US clinical trial registered for Chronic Myeloid Leukemia — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

36 US clinical trials · 14 currently recruiting

The research picture

Chronic Myeloid Leukemia has 36 registered US clinical trials, 14 of them open to new participants right now — about 39% of the total.

14
recruiting participants now
39%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
6
top sponsor: M.D. Anderson Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 2,000 participants

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

Alliance for Clinical Trials in Oncology

NCT05334069

RECRUITING Phase 3 285 participants

Study of Olverembatinib (HQP1351) in Patients With CP-CML

Ascentage Pharma Group

NCT06423911

RECRUITING Phase 1 242 participants

Study of HQP1351 in Subjects With Refractory CML and Ph+ ALL

Ascentage Pharma Group

NCT04260022

RECRUITING Phase 1 200 participants

A Phase 1a/1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia

Enliven Therapeutics

NCT05304377

RECRUITING Phase 1 180 participants

A Phase 1/2 Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of TERN-701 in Participants With Chronic Myeloid Leukemia (CARDINAL)

Terns

NCT06163430

RECRUITING Phase 1 130 participants

A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies

MacroGenics

NCT05362773

RECRUITING Phase 1 109 participants

KRT-232 and TKI Study in Chronic Myeloid Leukemia

Kartos Therapeutics

NCT04835584

RECRUITING Phase 2 100 participants

Safety And Efficacy Of TKI Cessation For CML Patients With Stable Molecular Response In A Real World Population

Baylor College of Medicine

NCT04626024

RECRUITING 75 participants

Impact of Personality on Adherence to Tyrosine Kinase Inhibitor Therapy in Pts w/Chronic Myeloid Leukemia

University of California, Irvine

NCT06229860

RECRUITING Phase 1 72 participants

A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias

Crossbow Therapeutics

NCT06994676

RECRUITING Phase 2 50 participants

Phase II Study Assessing the Efficacy and Toxicity of Olverembatinib Monotherapy in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase

M.D. Anderson Cancer Center

NCT06817720

RECRUITING Phase 2 50 participants

Phase II Study Assessing Efficacy and Safety of Asciminib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase.

M.D. Anderson Cancer Center

NCT06236724

RECRUITING Phase 2 20 participants

Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases

University of Florida

NCT05800210

RECRUITING Phase 1 18 participants

Selumetinib and Azacitidine in High Risk Chronic Blood Cancers

University of Chicago

NCT03326310

ACTIVE NOT RECRUITING Phase 2 313 participants

HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis

Center for International Blood and Marrow Transplant Research

NCT06001385

ACTIVE NOT RECRUITING Phase 1 255 participants

Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies

Orca Biosystems

NCT04013685

ACTIVE NOT RECRUITING Phase 3 21 participants

Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

Dartmouth-Hitchcock Medical Center

NCT03480360

ACTIVE NOT RECRUITING Phase 1 10 participants

CASPALLO: Allodepleted T Cells Transduced With Inducible Caspase 9 Suicide Gene

Baylor College of Medicine

NCT00710892

ACTIVE NOT RECRUITING NA 3 participants

Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion

Baylor College of Medicine

NCT05236764

COMPLETED 2,043 participants

Real-World Treatment Patterns and Outcomes Among Patients With Chronic Myeloid Leukemia in Earlier Lines of Therapy

Novartis Pharmaceuticals

NCT06692803

COMPLETED 480 participants

Patient Reported Outcomes in Chronic Myeloid Leukemia

Gruppo Italiano Malattie EMatologiche dell'Adulto

NCT01252589

COMPLETED Phase 2 150 participants

Dasatinib (BMS-354835) Versus Imatinib Mesylate in Subjects With Chronic Myeloid Leukemia

Bristol-Myers Squibb

NCT00103844

COMPLETED Phase 1 76 participants

PEG Interferon Alpha 2B and Low-Dose Ara-C in Early Chronic Phase CML

M.D. Anderson Cancer Center

NCT00303290

COMPLETED 75 participants

The Collection of Peripheral Blood Lymphocytes and Marrow Progenitor Cells From Normal Volunteers and Volunteers With Lymphoid or Hematologic Malignancies

National Cancer Institute (NCI)

NCT00001432

COMPLETED Phase 2 72 participants

Busulfan, Fludarabine, Clofarabine With Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT00469014

COMPLETED NA 47 participants

A Distress Reduction Intervention for Patients With BCR-ABL-Negative MPNs or CML on Tyrosine Kinase Inhibitors

University of California, San Francis

NCT04605211

COMPLETED 45 participants

Precision Dosing of Tyrosine Kinase Inhibitors in CML Patients

UNC Lineberger Comprehensive Cancer Center

NCT03885830

COMPLETED Phase 1 45 participants

Safety Study of Human Myeloid Progenitor Cells (CLT-008) After Chemotherapy for Leukemia

Cellerant Therapeutics

NCT01297543

COMPLETED Phase 2 40 participants

HLA-Nonidentical Stem Cell and Natural Killer Cell Transplantation for Children Less the Two Years of Age With Hematologic Malignancies

St. Jude Children's Research Hospital

NCT00145626

COMPLETED Phase 1 38 participants

Blinded Cross-Over Bioequivalence (BE) Trial of Luitpold Azacitidine vs Vidaza

American Regent

NCT01290302

COMPLETED Phase 2 36 participants

Phase II Study Evaluating Busulfan and Fludarabine as Preparative Therapy in Adults With Hematopoietic Disorders Undergoing MUD SCT

University of California, San Francis

NCT00516152

COMPLETED Phase 2 24 participants

Off-the-shelf NK Cells + SCT for Myeloid Malignancies

M.D. Anderson Cancer Center

NCT05115630

COMPLETED Phase 2 14 participants

Experimental Bone Marrow Transplant Protocol

National Heart, Lung, and Blood Institute (NHLBI)

NCT00061581

COMPLETED Phase 1 14 participants

Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies

Case Comprehensive Cancer Center

NCT02129582

COMPLETED Phase 2 11 participants

Synthetic Vaccine in Patients With Chronic Myeloid Leukemia and Minimal Residual Disease

M.D. Anderson Cancer Center

NCT00267085

COMPLETED Phase 2 7 participants

CD34 Selected Allogeneic HCT w/ Myeloablative Conditioning Plus CD8+ Memory TCell Infusion in MDS, AL and CML

Robert Lowsky

NCT04151706

Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 13
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Myeloid Leukemia Trial Landscape

ClinicalTrials.gov lists 36 US studies indexed under Chronic Myeloid Leukemia, and 14 of those are currently open to recruitment — roughly 39% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Chronic Myeloid Leukemia shows 2 late-stage studies (Phase 3 and Phase 4 combined) alongside 26 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Chronic Myeloid Leukemia is led by M.D. Anderson Cancer Center with 6 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 36 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Myeloid Leukemia?

PlainTrial tracks 36 US clinical trials for Chronic Myeloid Leukemia, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Myeloid Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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