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ClinicalTrials.gov 72 recruiting now official registry

Gastric Cancer clinical trials

72 of 159 indexed Gastric Cancer trials are currently recruiting.

159 US clinical trials · 72 currently recruiting

Gastric Cancer is the subject of 159 registered US clinical trials on ClinicalTrials.gov, 72 of them currently open to new participants. 17 are in Phase 3-4 (later-stage) and 118 in Phase 1-2 (earlier-stage). The most active sponsor is AstraZeneca, running 11 of these trials.

The research picture

Gastric Cancer has 159 registered US clinical trials, 72 of them open to new participants right now, about 45% of the total.

72
recruiting participants now
45%
of trials open to enrollment
17
in Phase 3–4 (later-stage)
11
top sponsor: AstraZeneca
Phase 169Phase 249Phase 313Phase 44

Active & Recent Trials

159 total, page 3 of 4

ACTIVE NOT RECRUITING Phase 1 72 participants

A Study Evaluating Bemarituzumab in Combination With Other Anti-cancer Therapies in Subjects With Previously Untreated Advanced Gastric or Gastroesophageal Junction Cancer.

Amgen

NCT05322577

ACTIVE NOT RECRUITING Phase 1 71 participants

MAGE-A4ᶜ¹º³²T for Multi-Tumor

Adaptimmune

NCT03132922

ACTIVE NOT RECRUITING Phase 1 71 participants

Study of NGM438 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors

NGM Biopharmaceuticals

NCT05311618

ACTIVE NOT RECRUITING Phase 1 70 participants

First in Human Study of TORL-2-307-MAB in Participants With Advanced Cancer

TORL Biotherapeutics

NCT05159440

ACTIVE NOT RECRUITING Phase 1 56 participants

Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells in Subjects With Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic Adenocarcinoma

Legend Biotech USA

NCT05539430

ACTIVE NOT RECRUITING Phase 2 40 participants

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

ImmunityBio

NCT03228667

ACTIVE NOT RECRUITING Phase 2 40 participants

Study of Sequential Systemic Therapy + Intraperitoneal Paclitaxel in Gastric/GEJ Peritoneal Carcinomatosis

University of California, Irvine

NCT04762953

ACTIVE NOT RECRUITING Phase 1 40 participants

Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers

Arcus Biosciences

NCT05891171

ACTIVE NOT RECRUITING Phase 1 32 participants

Nivolumab +/- Relatlimab Prior to Chemoradiation With II/III Gastro/Esophageal Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03044613

ACTIVE NOT RECRUITING NA 32 participants

Using an End-of-life Conversation Game to Engage Patients With Cancer in Advance Care Planning: Phase 2

Milton S. Hershey Medical Center

NCT06384417

ACTIVE NOT RECRUITING Phase 2 9 participants

Study of SBRT/Olaparib Followed by Pembrolizumab/Olaparib in Gastric Cancers

University of Colorado, Denver

NCT05379972

ACTIVE NOT RECRUITING 4 participants

A Study of Minimally Invasive Proximal Gastrectomy Versus Minimally Invasive Total Gastrectomy for Gastric and Gastroesophageal Junction Cancers

Memorial Sloan Kettering Cancer Center

NCT06243757

COMPLETED 971 participants

Early Onset and Familial Gastric Cancer Registry

Memorial Sloan Kettering Cancer Center

NCT00582257

COMPLETED 809 participants

Stomach Cancer Exosome-based Detection

City of Hope Medical Center

NCT06342427

COMPLETED Phase 3 780 participants

A Study of Pertuzumab in Combination With Trastuzumab and Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Gastroesophageal Junction or Gastric Cancer

Hoffmann-La Roche

NCT01774786

COMPLETED Phase 3 665 participants

A Study of Paclitaxel With or Without Ramucirumab (IMC-1211B) in Metastatic Gastric Adenocarcinoma

Eli Lilly and Company

NCT01170663

COMPLETED Phase 3 546 participants

Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer

Alliance for Clinical Trials in Oncology

NCT00052910

COMPLETED Phase 3 405 participants

Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers

Alliance for Clinical Trials in Oncology

NCT02349412

COMPLETED Phase 2 274 participants

An Investigational Study of Immunotherapy Combinations With Chemotherapy in Patients With Gastric or Gastroesophageal Junction (GEJ) Cancers

Bristol-Myers Squibb

NCT03662659

COMPLETED Phase 2 195 participants

Phase II Randomized Trial of Bethesda Protocol Compared to Cambridge Method for Detection of Early Stage Gastric Cancer in CDH1 Mutation Carriers

National Cancer Institute (NCI)

NCT04535414

COMPLETED Phase 3 161 participants

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Dan Zandberg

NCT04157985

COMPLETED Phase 2 138 participants

A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)

Sanofi

NCT05104567

COMPLETED Phase 1 120 participants

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Novartis Pharmaceuticals

NCT01576666

COMPLETED 115 participants

Visceral Lymphatic Mapping Using Isosulfan Blue in Patients With Cancer of the Pancreas, Colon, Stomach, Small Intestine, or Gallbladder

Wake Forest University Health Sciences

NCT00489515

COMPLETED 112 participants

Prospective Analysis of Hypersensitivity Reactions to Oxaliplatin

Dana-Farber Cancer Institute

NCT00831571

COMPLETED Phase 2 111 participants

Study of Modified Docetaxel, Cisplatin, and Fluorouracil (mDCF) in Unresectable or Metastatic Gastric and Gastroesophageal Junction Adenocarcinoma

Memorial Sloan Kettering Cancer Center

NCT00515411

COMPLETED Phase 2 97 participants

Radiation Therapy and Chemotherapy Before and After Surgery in Treating Patients With Esophageal Cancer

Eastern Cooperative Oncology Group

NCT00033657

COMPLETED Phase 1 85 participants

A Study of Ramucirumab (LY3009806) Plus MEDI4736 in Participants With Advanced Gastrointestinal or Thoracic Malignancies

Eli Lilly and Company

NCT02572687

COMPLETED Phase 1 79 participants

Open-Label, Dose-Finding Study Evaluating Safety and PK of FPA144 in Patients With Advanced Solid Tumors

Five Prime Therapeutics

NCT02318329

COMPLETED Phase 4 66 participants

Improving Complete Endoscopic Mucosal Resection (EMR) of Colorectal Neoplasia

Mayo Clinic

NCT01471756

COMPLETED Phase 2 61 participants

S0101 Gemcitabine and Irinotecan in Treating Patients With Metastatic or Recurrent Cancer of the Esophagus

SWOG Cancer Research Network

NCT00012363

COMPLETED Phase 1 59 participants

Docetaxel, Oxaliplatin, and Fluorouracil in Treating Patients With Metastatic or Unresectable Stomach Cancer, Gastroesophageal Junction Cancer, or Other Solid Tumor

Northwestern University

NCT00711243

COMPLETED Phase 2 58 participants

Preoperative Chemo and Chemoradiotherapy for Adenocarcinoma of the Stomach and Gastroesophageal Junction (GEJ)

M.D. Anderson Cancer Center

NCT00525785

COMPLETED Phase 1 56 participants

A Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) With Pembrolizumab in Participants With Selected Hyaluronan High Solid Tumors

Halozyme Therapeutics

NCT02563548

COMPLETED Phase 2 54 participants

Taxotere, Cisplatin and Irinotecan (CPT-11) for Esophagogastric Cancer

Dana-Farber Cancer Institute

NCT00165464

COMPLETED NA 52 participants

Imaging Study on Halcyon 4.0 System for Patients Receiving Radiation Therapy

Washington University School of Medicine

NCT05427214

COMPLETED Phase 2 51 participants

Irinotecan and Paclitaxel in Treating Patients With Metastatic or Recurrent Cancer of the Esophagus or Stomach

Jonsson Comprehensive Cancer Center

NCT00020761

COMPLETED Phase 2 48 participants

A Study of Telatinib in Combination With Chemotherapy in Subjects With Advanced Gastric Cancer

ACT Biotech

NCT00952497

COMPLETED Phase 2 48 participants

Oxaliplatin and Capecitabine in Treating Patients With Advanced Esophageal Cancer or Stomach Cancer

Alliance for Clinical Trials in Oncology

NCT00040859

COMPLETED Phase 2 46 participants

Docetaxel and Capecitabine in Treating Patients With Metastatic Cancer of the Stomach or Gastroesophageal Junction

Alliance for Clinical Trials in Oncology

NCT00054457

COMPLETED Phase 2 45 participants

Combination Chemotherapy in Treating Patients With Stage III Ovarian Epithelial Cancer or Gastrointestinal Cancer

NYU Langone Health

NCT00005049

COMPLETED Phase 2 43 participants

Use of Cetuximab for Unresectable or Metastatic Esophageal and Gastric Cancer

Dana-Farber Cancer Institute

NCT00130689

COMPLETED Phase 2 40 participants

Irinotecan in Treating Patients With Esophageal or Stomach Cancer

Jonsson Comprehensive Cancer Center

NCT00003748

COMPLETED Phase 1 40 participants

A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies

Incyte Corporation

NCT03652077

COMPLETED Phase 2 39 participants

FOLFOX With Bevacizumab in Metastatic or Unresectable Gastroesophageal and Gastric Cancer

Yale University

NCT00673673

COMPLETED Phase 2 39 participants

FOLFOX Plus Regorafenib in Patients With Unresectable or Metastatic Esophagogastric Cancer

Memorial Sloan Kettering Cancer Center

NCT01913639

COMPLETED Phase 2 33 participants

Fluorouracil, Oxaliplatin, and Leucovorin in Treating Patients With Metastatic Stomach Cancer or Gastroesophageal Junction Cancer

Vanderbilt-Ingram Cancer Center

NCT00514020

COMPLETED Phase 2 28 participants

Adjuvant Intraperitoneal Floxuridine Added to Chemoradiation for Fully Resected Advanced Stomach Cancer

NYU Langone Health

NCT00858338

COMPLETED Phase 2 25 participants

Study of 5-Fluorouracil and Leucovorin and Intra-abdominal Floxuridine Chemoradiation in Patients With Fully Resected Locally Advanced Gastric Adenocarcinoma

University of Southern California

NCT00183911

COMPLETED Phase 2 24 participants

Vaccine Therapy, Interleukin-2, and Sargramostim in Treating Patients With Advanced Tumors

Georgetown University

NCT00003125

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Phase Distribution

PhaseTrial count
Phase 1 69
Phase 2 49
Phase 3 13
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Gastric Cancer Trial Landscape

159 indexed Gastric Cancer studies · 72 recruiting (45%).

Phase mix: 17 late (III/IV) vs 118 early (I/II).

Top sponsor: AstraZeneca (11 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Gastric Cancer?

PlainTrial tracks 159 US clinical trials for Gastric Cancer, of which 72 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Gastric Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.