Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 2

Study of Modified Docetaxel, Cisplatin, and Fluorouracil (mDCF) in Unresectable or Metastatic Gastric and Gastroesophageal Junction Adenocarcinoma

NCT00515411 · View on ClinicalTrials.gov ↗

Study Summary

Chemotherapy given together is a standard way to treat your cancer. One standard treatment includes a combination of docetaxel, cisplatin, and fluorouracil. However, the original combination of these three drugs can cause many side effects. This study is being done to find out if these three drugs can be given at lower doses more often, with fewer side effects and still maintain the same benefit as the standard way of giving this three drug combination. If your tumor overexpresses a protein called Her2, you are also eligible to receive trastuzumab with chemotherapy. Trastuzumab is a medicine that has been approved by the US Food and Drug Administration for the treatment of Her2 positive breast cancer. Trastuzumab is now also a standard treatment in combination with chemotherapy for the treatment of Her2 positive stomach cancer. If your tumor is Her2 positive, you would receive the modified administration schedule of docetaxel, cisplatin, and fluorouracil with trastuzumab.

Interventions

  • DRUG Docetaxel, Leucovorin, Fluorouracil, Cisplatin
  • DRUG Docetaxel, Cisplatin, Fluorouracil, Neulasta, or Neupogen
  • DRUG Docetaxel, Leukvorin, Flurouracil, Cisplatin, Trastuzumab

Study Locations (15)

New York

  • Memorial Sloan-Kettering Cancer Center @ Suffolk — Commack
  • Queens Cancer Center of Queens Hospital — Jamaica
  • Long Island Jewish Medical Center — New Hyde Park
  • Weill Medical College of Cornell University — New York
  • Memorial Sloan Kettering Cancer Center 1275 York Avenue — New York
  • Memorial Sloan Kettering at Mercy Medical Center — Rockville Centre
  • Memoral Sloan Kettering Cancer Center@Phelps Memorial Hospital — Sleepy Hollow

California

  • City of Hope Cancer Center — Duarte

Florida

  • Memorial Cancer Institute — Pembroke Pines

Georgia

  • Piedmont Hospital Research Institute — Atlanta

Nebraska

  • Nebraska Cancer Specialists, Methodist Estabrook Cancer Center — Omaha

New Jersey

  • Memoral Sloan Kettering Cancer Center — Basking Ridge

Ohio

  • University Hospital of Cleveland — Cleveland

Pennsylvania

  • University of Pittsburgh Cancer Institute — Pittsburgh

Trial Details

FieldValue
Enrollment Target 111 participants
Start Date 2006-10-23
Est. Completion 2018-10-26
Phase Phase 2

Sponsor

Memorial Sloan Kettering Cancer Center

2,280 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00515411

The ClinicalTrials.gov registry entry for NCT00515411 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 111 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Memorial Sloan Kettering Cancer Center, which has 2,280 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Gastric Cancer appearing as the primary indexed condition, and to 3 interventions — of which Docetaxel, Leucovorin, Fluorouracil, Cisplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00515411 reports 15 study locations spanning 9 distinct geographic areas — top geographies include New York, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00515411 about?

NCT00515411 is a clinical study titled "Study of Modified Docetaxel, Cisplatin, and Fluorouracil (mDCF) in Unresectable or Metastatic Gastric and Gastroesophageal Junction Adenocarcinoma". Chemotherapy given together is a standard way to treat your cancer. One standard treatment includes a combination of docetaxel, cisplatin, and fluorouracil. However, the original combination of these three drugs can cause many side effects. This study is being done to find out if these three drugs c...

What is the current status of trial NCT00515411?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 111 participants. The study started on 2006-10-23. Estimated completion is 2018-10-26.

What conditions does trial NCT00515411 study?

This clinical trial studies the following conditions: Gastric Cancer, Gastroesophageal Junction Adenocarcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00515411?

The interventions under investigation include: Docetaxel, Leucovorin, Fluorouracil, Cisplatin (DRUG), Docetaxel, Cisplatin, Fluorouracil, Neulasta, or Neupogen (DRUG), Docetaxel, Leukvorin, Flurouracil, Cisplatin, Trastuzumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00515411?

This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 2,280 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00515411 being conducted?

This trial has 15 study locations across California, Florida, Georgia, Nebraska, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial