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Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer
NCT00052910 · View on ClinicalTrials.gov ↗
Study Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy after surgery may kill any remaining tumor cells following surgery. It is not yet known which chemotherapy and radiation therapy regimen is more effective in treating stomach or esophageal cancer. PURPOSE: Randomized phase III trial to compare two different chemotherapy and radiation therapy regimens in treating patients who have undergone surgery for stomach or esophageal cancer.
Conditions Studied
Interventions
- DRUG cisplatin
- DRUG fluorouracil
- DRUG epirubicin hydrochloride
- DRUG leucovorin calcium
- RADIATION radiation therapy
Study Locations (20)
California
- Kaiser Permanente - Deer Valley — Antioch
- Providence Saint Joseph Medical Center - Burbank — Burbank
- East Bay Radiation Oncology Center — Castro Valley
- Eden Medical Center — Castro Valley
- Valley Medical Oncology Consultants - Castro Valley — Castro Valley
- City of Hope Comprehensive Cancer Center — Duarte
- Kaiser Permanente - Fremont — Fremont
- Valley Medical Oncology — Fremont
- Glendale Memorial Hospital Comprehensive Cancer Center — Glendale
- Kaiser Permanente Medical Center - Hayward — Hayward
- Rebecca and John Moores UCSD Cancer Center — La Jolla
- Contra Costa Regional Medical Center — Martinez
- Memorial Medical Center — Modesto
Arkansas
- Hembree Mercy Cancer Center at St. Edward Mercy Medical Center — Fort Smith
- Ben E. Owens Cancer Treatment Center at St. Bernard's Medical Center — Jonesboro
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock
Alabama
- Regional Medical Center — Anniston
- Providence Cancer Center at Providence Hospital — Mobile
Arizona
- Mayo Clinic Scottsdale — Scottsdale
- Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 546 participants |
| Start Date | 2002-12 |
| Est. Completion | 2016-12 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00052910
The ClinicalTrials.gov registry entry for NCT00052910 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 546 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alliance for Clinical Trials in Oncology, which has 147 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Gastric Cancer appearing as the primary indexed condition, and to 5 interventions — of which cisplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00052910 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Arkansas, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00052910 about?
NCT00052910 is a clinical study titled "Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer". RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with radiation therapy after surgery may kill any remaining tumor cells following surgery. I...
What is the current status of trial NCT00052910?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 546 participants. The study started on 2002-12. Estimated completion is 2016-12.
What conditions does trial NCT00052910 study?
This clinical trial studies the following conditions: Gastric Cancer, Esophageal Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00052910?
The interventions under investigation include: cisplatin (DRUG), fluorouracil (DRUG), epirubicin hydrochloride (DRUG), leucovorin calcium (DRUG), radiation therapy (RADIATION). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00052910?
This trial is sponsored by Alliance for Clinical Trials in Oncology, which has 147 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00052910 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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