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NCT05159440 · ClinicalTrials.gov registry record · Phase 1

First in Human Study of TORL-2-307-MAB in Participants With Advanced Cancer

A Phase 1 study of Advanced Solid Tumor and Gastric Cancer, sponsored by TORL Biotherapeutics.

Active
Registry status
Phase 1
Development phase
70
Enrollment target
8
Study locations

NCT05159440: Active Phase 1 study of Advanced Solid Tumor and Gastric Cancer, sponsored by TORL Biotherapeutics.

NCT05159440 is a Phase 1 study of Advanced Solid Tumor and Gastric Cancer that is active but no longer recruiting, run by TORL Biotherapeutics. The registered enrollment target is 70 participants, below the 193-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (64% lower). The trial reports 8 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05159440, a Phase 1 study of Advanced Solid Tumor and Gastric Cancer, is active but no longer recruiting, sponsored by TORL Biotherapeutics.

ACTIVE NOT RECRUITING
Registry status
Phase 1
Development phase
70 participants
Enrollment target
8
Study locations

Study Summary

This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-2-307-MAB in patients with advanced cancer

Primary Outcome

Incidence and severity of adverse events, serious adverse events, according to NCI-CTCAE Version 5.0

Conditions Studied

Advanced Solid Tumor Gastric Cancer Pancreas Cancer Gastroesophageal Junction Adenocarcinoma

Interventions

  • DRUG TORL-2-307-MAB

Study Locations (8)

California

  • Providence St. Jude Medical Center - Fullerton
  • UCLA - JCCC Clinical Research Unit - Los Angeles
  • Torrance Memorial Medical - Torrance

Other

  • Seoul National University Hospital - Seoul
  • Severance Hospital, Yonsei University Health System - Seoul
  • Seoul National University Bundang Hospital - Seoul

Indiana

  • Fort Wayne Medical Oncology and Hematology - Fort Wayne

Missouri

  • Washington University School of Medicine-Siteman Cancer Center - St Louis

Trial Details

FieldValue
Enrollment Target 70 participants
Start Date 2022-01-20
Est. Completion 2025-12-15
Phase Phase 1
TORL Biotherapeutics

8 total trials

What the registry record for NCT05159440 still lists

NCT05159440 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 193-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (64% lower).

The record links to 4 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 1 intervention - of which TORL-2-307-MAB is the first listed.

NCT05159440 lists 8 locations in 4 states (California, Other, Indiana).

Frequently Asked Questions

What is clinical trial NCT05159440 about?

NCT05159440 is a clinical study titled "First in Human Study of TORL-2-307-MAB in Participants With Advanced Cancer". This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-2-307-MAB in patients with advanced cancer

What is the current status of trial NCT05159440?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 70 participants. The study started on 2022-01-20. Estimated completion is 2025-12-15.

What conditions does trial NCT05159440 study?

This clinical trial studies the following conditions: Advanced Solid Tumor, Gastric Cancer, Pancreas Cancer, Gastroesophageal Junction Adenocarcinoma.

What interventions are being tested in trial NCT05159440?

The interventions under investigation include: TORL-2-307-MAB (DRUG).

Who is sponsoring clinical trial NCT05159440?

This trial is sponsored by TORL Biotherapeutics, which has 8 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05159440 being conducted?

This trial has 8 study locations across California, Indiana, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Advanced Solid Tumor

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05159440's enrollment target sits among peer trials

70 142nd of 189 higher than 42 of 189 other Advanced Solid Tumor trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Advanced Solid Tumor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT05159440, the US trial registry maintained by the National Library of Medicine. NCT05159440 (small enrollment · multi site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.