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ClinicalTrials.gov 63 recruiting now official registry

Esophageal Cancer clinical trials

63 of 132 indexed Esophageal Cancer trials are currently recruiting.

132 US clinical trials · 63 currently recruiting

Esophageal Cancer is the subject of 132 registered US clinical trials on ClinicalTrials.gov, 63 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 84 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 10 of these trials.

The research picture

Esophageal Cancer has 132 registered US clinical trials, 63 of them open to new participants right now, about 48% of the total.

63
recruiting participants now
48%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
10
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 149Phase 235Phase 35Phase 43

Active & Recent Trials

132 total, page 2 of 3

RECRUITING Phase 1 45 participants

Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

Baylor College of Medicine

NCT03740256

RECRUITING Phase 1 42 participants

CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer

Washington University School of Medicine

NCT05187182

RECRUITING Phase 1 33 participants

Phase 1 Trial of ZM008 as Single Agent and in Combination With Pembrolizumab in Patients With Advanced Solid Tumors

Zumutor Biologics

NCT06451497

RECRUITING 30 participants

Volume Outcome Relationships and Effects

Methodist Health System

NCT06343597

RECRUITING Phase 1 27 participants

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

Tanabe Pharma America

NCT06943521

RECRUITING Phase 1 26 participants

64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer

Lantheus Medical Imaging

NCT06298916

RECRUITING Phase 4 22 participants

Pharmacokinetic Study of Skeletal Muscle Area-based Paclitaxel Infusion in Patients With Cancer

University of Michigan Rogel Cancer Center

NCT05183126

RECRUITING NA 20 participants

Impact of Prehabilitation in Oncology Via Exercise- Esophageal (IMPROVE-Esophageal)

University of Pittsburgh

NCT06872515

RECRUITING NA 20 participants

Exercise Prehabilitation for Locoregional Esophageal Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT06430346

RECRUITING Phase 1 18 participants

Intra-tumoral (IT) Injection of vvDD-hIL2-2-RG-1 for Metastatic Gastrointestinal and Peritoneal Tumors

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

NCT07001592

RECRUITING Phase 1 16 participants

Hypoxia Imaging for Esophageal Cancer to Guide Personalized Radiation Therapy

University of Utah

NCT04846309

RECRUITING Phase 4 15 participants

Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™)

Cedars-Sinai Medical Center

NCT07124351

RECRUITING Phase 1 11 participants

Brodalumab in the Treatment of Immune-Related Adverse Events

Brian Henick, MD

NCT06673329

ACTIVE NOT RECRUITING 6,000 participants

Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract

Memorial Sloan Kettering Cancer Center

NCT00582647

ACTIVE NOT RECRUITING Phase 2 147 participants

Proton Beam Therapy (PBT) Versus Intensity-Modulated Radiation Therapy (IMRT) Trial

M.D. Anderson Cancer Center

NCT01512589

ACTIVE NOT RECRUITING Phase 1 130 participants

Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors

NGM Biopharmaceuticals

NCT05215574

ACTIVE NOT RECRUITING Phase 1 120 participants

ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)

Uswm CT

NCT04044859

ACTIVE NOT RECRUITING Phase 1 120 participants

Oral Axl/Mer/CSF1R Selective Tyrosine Kinase Inhibitor Q702 in Combination With Pembrolizumab in Patients With Selected Advanced Solid Tumors

Qurient Co.

NCT05438420

ACTIVE NOT RECRUITING 110 participants

BEST-RPP Pilot: Screening for Esophageal Cancer in Rural Oregon Without an Endoscopy

OHSU Knight Cancer Institute

NCT06335966

ACTIVE NOT RECRUITING Phase 1 98 participants

A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors

Sensei Biotherapeutics

NCT05864144

ACTIVE NOT RECRUITING Phase 1 97 participants

A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants with Advanced Unresectable or Metastatic Solid Tumors

NextCure

NCT05572684

ACTIVE NOT RECRUITING NA 90 participants

Sentinel Lymph Node Mapping in Esophageal Cancer Using ICG Dye and NIR Imaging

Memorial Sloan Kettering Cancer Center

NCT04400292

ACTIVE NOT RECRUITING Phase 2 90 participants

Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers

Duke University

NCT03403465

ACTIVE NOT RECRUITING Phase 1 71 participants

MAGE-A4ᶜ¹º³²T for Multi-Tumor

Adaptimmune

NCT03132922

ACTIVE NOT RECRUITING Phase 1 71 participants

Study of NGM438 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumors

NGM Biopharmaceuticals

NCT05311618

ACTIVE NOT RECRUITING Phase 1 67 participants

Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas

Immunitas Therapeutics

NCT05565417

ACTIVE NOT RECRUITING Phase 1 56 participants

Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells in Subjects With Unresectable, Locally Advanced, or Metastatic Gastric, Gastroesophageal Junction (GEJ), Esophageal, or Pancreatic Adenocarcinoma

Legend Biotech USA

NCT05539430

ACTIVE NOT RECRUITING Phase 1 40 participants

Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers

Arcus Biosciences

NCT05891171

ACTIVE NOT RECRUITING Phase 2 39 participants

Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma

UNC Lineberger Comprehensive Cancer Center

NCT03174275

ACTIVE NOT RECRUITING Phase 1 32 participants

Nivolumab +/- Relatlimab Prior to Chemoradiation With II/III Gastro/Esophageal Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03044613

ACTIVE NOT RECRUITING Phase 1 30 participants

Dose Escalation of Neoadjuvant Proton Beam Radiotherapy With Concurrent Chemotherapy in Locally Advanced Esophageal Cancer

Abramson Cancer Center at Penn Medicine

NCT02213497

ACTIVE NOT RECRUITING NA 22 participants

Proton Beam Therapy in the Treatment of Esophageal Cancer

Washington University School of Medicine

NCT03482791

ACTIVE NOT RECRUITING Phase 1 14 participants

Cryotherapy for Locally Advanced Esophageal Cancer

Hunter Holmes Mcguire Veteran Affairs Medical Center

NCT04248582

ACTIVE NOT RECRUITING Phase 1 12 participants

Radiation Dose Intensification With Accelerated Hypofractionated Intensity Modulated Radiation Therapy and Concurrent Carboplatin and Paclitaxel for Inoperable Esophageal Cancer

Washington University School of Medicine

NCT04046575

ACTIVE NOT RECRUITING Phase 2 1 participants

Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction

Brown University

NCT05480384

ACTIVE NOT RECRUITING

Genetic and Environmental Risk Factors Related to Esophageal Cancer

Massachusetts General Hospital

NCT01035398

COMPLETED 1,429 participants

PRospective REgistry of Advanced Stage CancER (PREFER) Patients to Assess Prevalence of Actionable Biomarkers and Driver Mutations to Address Disparities in Precision Medicine

Labcorp Corporation of America Holdings

NCT05697198

COMPLETED NA 1,053 participants

Evaluations of Alcohol Warning Labels

University of Connecticut

NCT06129487

COMPLETED Phase 3 546 participants

Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer

Alliance for Clinical Trials in Oncology

NCT00052910

COMPLETED Phase 3 405 participants

Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers

Alliance for Clinical Trials in Oncology

NCT02349412

COMPLETED Phase 2 257 participants

PET Scan Imaging in Assessing Response in Patients With Esophageal Cancer Receiving Combination Chemotherapy

Alliance for Clinical Trials in Oncology

NCT01333033

COMPLETED 112 participants

Prospective Analysis of Hypersensitivity Reactions to Oxaliplatin

Dana-Farber Cancer Institute

NCT00831571

COMPLETED NA 100 participants

Interactive Voice Response System (IVRS) for Managing Symptoms of Patients Following Thoracic Surgery

M.D. Anderson Cancer Center

NCT00505024

COMPLETED Phase 3 100 participants

Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis

Covenant Health Cancer Center

NCT05369234

COMPLETED Phase 2 98 participants

S0356 Oxaliplatin, 5-FU, Radiation Therapy (RT), Surgery for Pts With Stage II or III Cancer of Esophagus or Gastroesophageal (GE) Junction

SWOG Cancer Research Network

NCT00086996

COMPLETED Phase 2 97 participants

Radiation Therapy and Chemotherapy Before and After Surgery in Treating Patients With Esophageal Cancer

Eastern Cooperative Oncology Group

NCT00033657

COMPLETED Phase 2 80 participants

Radiotherapy,Chemotherapy,Before and After Surgery in Advanced Esophageal or Gastroesophageal Junction Cancer

Case Comprehensive Cancer Center

NCT00258323

COMPLETED Phase 2 75 participants

PET Scan in Patients With Lung and Esophageal Cancers That May Be Removed by Surgery

Memorial Sloan Kettering Cancer Center

NCT00002930

COMPLETED Phase 2 61 participants

S0101 Gemcitabine and Irinotecan in Treating Patients With Metastatic or Recurrent Cancer of the Esophagus

SWOG Cancer Research Network

NCT00012363

COMPLETED Phase 2 54 participants

Taxotere, Cisplatin and Irinotecan (CPT-11) for Esophagogastric Cancer

Dana-Farber Cancer Institute

NCT00165464

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Phase Distribution

PhaseTrial count
Phase 1 49
Phase 2 35
Phase 3 5
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Esophageal Cancer Trial Landscape

132 indexed Esophageal Cancer studies · 63 recruiting (48%).

Phase mix: 8 late (III/IV) vs 84 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (10 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Esophageal Cancer?

PlainTrial tracks 132 US clinical trials for Esophageal Cancer, of which 63 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Esophageal Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.