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ACTIVE NOT RECRUITING Phase 1

A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors

NCT05864144 · View on ClinicalTrials.gov ↗

Study Summary

Phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of SNS-101, a novel anti VISTA IgG1 monoclonal antibody as monotherapy or in combination with cemiplimab in patients with advanced solid tumors.

Interventions

  • DRUG Cemiplimab
  • DRUG SNS-101 (anti-VISTA)

Study Locations (10)

Texas

  • NEXT Oncology Dallas — Irving
  • South Texas Accelerated Research Therapeutics (START) San Antonio — San Antonio

California

  • UCLA Hematology/Oncology — Los Angeles

Colorado

  • University of Colorado Cancer Center - Anschutz Medical — Aurora

Kentucky

  • Norton Healthcare — Louisville

Michigan

  • Henry Ford Cancer — Detroit

New York

  • Icahn School of Medicine at Mt. Sinai — New York

Pennsylvania

  • University of Pennsylvania, Perelman Center for Advanced Medicine — Philadelphia

South Dakota

  • Sanford Cancer Center — Sioux Falls

Trial Details

FieldValue
Enrollment Target 98 participants
Start Date 2023-05-31
Est. Completion 2027-06
Phase Phase 1

Sponsor

Sensei Biotherapeutics

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05864144

The ClinicalTrials.gov registry entry for NCT05864144 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 98 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Sensei Biotherapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Breast Cancer appearing as the primary indexed condition, and to 2 interventions — of which Cemiplimab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05864144 reports 10 study locations spanning 9 distinct geographic areas — top geographies include Texas, California, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05864144 about?

NCT05864144 is a clinical study titled "A Study of SNS-101 (Anti VISTA) Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors". Phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of SNS-101, a novel anti VISTA IgG1 monoclonal antibody as monotherapy or in combination with cemiplimab in patients with advanced solid tumors.

What is the current status of trial NCT05864144?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 98 participants. The study started on 2023-05-31. Estimated completion is 2027-06.

What conditions does trial NCT05864144 study?

This clinical trial studies the following conditions: Breast Cancer, Prostate Cancer, Pancreatic Cancer, Head and Neck Cancer, Advanced Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05864144?

The interventions under investigation include: Cemiplimab (DRUG), SNS-101 (anti-VISTA) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05864144?

This trial is sponsored by Sensei Biotherapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05864144 being conducted?

This trial has 10 study locations across California, Colorado, Kentucky, Michigan, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial