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NCT05480384 · ClinicalTrials.gov registry record · Phase 2
Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction
A Phase 2 study of Esophageal Cancer and Esophageal Adenocarcinoma, sponsored by Brown University.
- Active
- Registry status
- Phase 2
- Development phase
- 1
- Enrollment target
- 2
- Study locations
NCT05480384 is a Phase 2 study of Esophageal Cancer and Esophageal Adenocarcinoma that is active but no longer recruiting, run by Brown University. The registered enrollment target is 1 participants, below the 499-participant average among 123 other Esophageal Cancer trials with a reported enrollment target (100% lower). The trial reports 2 study locations across 2 states.
The verdict
NCT05480384, a Phase 2 study of Esophageal Cancer and Esophageal Adenocarcinoma, is active but no longer recruiting, sponsored by Brown University.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 1 participants
- Enrollment target
- 2
- Study locations
Study Summary
An open label phase II study to determine the safety and preliminary efficacy of the combination of 1-year of adjuvant trastuzumab deruxtecan and nivolumab for patients with HER2 overexpressing esophagogastric adenocarcinoma who have completed chemoradiation followed by esophagectomy.
Conditions Studied
Interventions
- DRUG Nivolumab
- DRUG Trastuzumab deruxtecan
Study Locations (2)
New York
- Weill Cornell Medicine/New York-Presbyterian - New York
Rhode Island
- Lifespan Cancer Institute - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1 participants |
| Start Date | 2023-07-14 |
| Est. Completion | 2026-01 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05480384
The ClinicalTrials.gov registry entry for NCT05480384 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 1 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 499-participant average among 123 other Esophageal Cancer trials with a reported enrollment target (100% lower). The listed sponsor is Brown University, which has 231 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Esophageal Cancer appearing as the primary indexed condition, and to 2 interventions - of which Nivolumab is the first listed.
NCT05480384 reports 2 study locations spanning 2 distinct geographic areas - top geographies include New York, Rhode Island.
Frequently Asked Questions
What is clinical trial NCT05480384 about?
NCT05480384 is a clinical study titled "Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction". An open label phase II study to determine the safety and preliminary efficacy of the combination of 1-year of adjuvant trastuzumab deruxtecan and nivolumab for patients with HER2 overexpressing esophagogastric adenocarcinoma who have completed chemoradiation followed by esophagectomy.
What is the current status of trial NCT05480384?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 1 participants. The study started on 2023-07-14. Estimated completion is 2026-01.
What conditions does trial NCT05480384 study?
This clinical trial studies the following conditions: Esophageal Cancer, Esophageal Adenocarcinoma, Gastroesophageal-junction Cancer, HER-2 Protein Overexpression.
What interventions are being tested in trial NCT05480384?
The interventions under investigation include: Nivolumab (DRUG), Trastuzumab deruxtecan (DRUG).
Who is sponsoring clinical trial NCT05480384?
This trial is sponsored by Brown University, which has 231 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05480384 being conducted?
This trial has 2 study locations across New York, Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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