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ClinicalTrials.gov 63 recruiting now official registry

Esophageal Cancer clinical trials

63 of 132 indexed Esophageal Cancer trials are currently recruiting.

132 US clinical trials · 63 currently recruiting

Esophageal Cancer is the subject of 132 registered US clinical trials on ClinicalTrials.gov, 63 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 84 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 10 of these trials.

The research picture

Esophageal Cancer has 132 registered US clinical trials, 63 of them open to new participants right now, about 48% of the total.

63
recruiting participants now
48%
of trials open to enrollment
8
in Phase 3–4 (later-stage)
10
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 149Phase 235Phase 35Phase 43

Active & Recent Trials

132 total, page 3 of 3

COMPLETED Phase 2 51 participants

Irinotecan and Paclitaxel in Treating Patients With Metastatic or Recurrent Cancer of the Esophagus or Stomach

Jonsson Comprehensive Cancer Center

NCT00020761

COMPLETED Phase 2 48 participants

Oxaliplatin and Capecitabine in Treating Patients With Advanced Esophageal Cancer or Stomach Cancer

Alliance for Clinical Trials in Oncology

NCT00040859

COMPLETED Phase 2 46 participants

Docetaxel and Capecitabine in Treating Patients With Metastatic Cancer of the Stomach or Gastroesophageal Junction

Alliance for Clinical Trials in Oncology

NCT00054457

COMPLETED Phase 2 44 participants

Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients With Esophageal or Gastroesophageal Junction Cancer

Northwestern University

NCT00711412

COMPLETED Phase 2 43 participants

A Study of Patients Receiving High-Dose Rate Brachytherapy

National Cancer Institute (NCI)

NCT00924027

COMPLETED Phase 2 43 participants

Use of Cetuximab for Unresectable or Metastatic Esophageal and Gastric Cancer

Dana-Farber Cancer Institute

NCT00130689

COMPLETED Phase 2 41 participants

Cetuximab and Radiation Therapy for Surgically Resectable Esophageal and Gastroesophageal (GE) Junction Carcinomas

Nasser Hanna, M.D.

NCT00319735

COMPLETED Phase 2 40 participants

Irinotecan in Treating Patients With Esophageal or Stomach Cancer

Jonsson Comprehensive Cancer Center

NCT00003748

COMPLETED Phase 1 40 participants

A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies

Incyte Corporation

NCT03652077

COMPLETED Phase 2 39 participants

FOLFOX Plus Regorafenib in Patients With Unresectable or Metastatic Esophagogastric Cancer

Memorial Sloan Kettering Cancer Center

NCT01913639

COMPLETED Phase 2 39 participants

A Study of Durvalumab (MEDI4736) in Esophageal Cancer

Shadia Jalal, MD

NCT02639065

COMPLETED Phase 1 38 participants

A First in Human, Dose Escalation Study of JAB-3068 (SHP2 Inhibitor) in Adult Patients With Advanced Solid Tumors

Jacobio Pharmaceuticals Co.

NCT03518554

COMPLETED Phase 2 35 participants

Sorafenib for Patients With Metastatic or Recurrent Esophageal and Gastroesophageal Junction Cancer

Memorial Sloan Kettering Cancer Center

NCT00917462

COMPLETED NA 31 participants

FDG-PET-CT and Biomarkers in Esophageal Cancer

M.D. Anderson Cancer Center

NCT00833625

COMPLETED Phase 2 30 participants

Photodynamic Therapy in Treating Patients With Early Esophageal Cancer

Roswell Park Cancer Institute

NCT00002935

COMPLETED Phase 2 24 participants

Vaccine Therapy, Interleukin-2, and Sargramostim in Treating Patients With Advanced Tumors

Georgetown University

NCT00003125

COMPLETED Phase 1 24 participants

Combination Chemotherapy and Radiation Therapy in Treating Patients With Cancer of the Esophagus

Memorial Sloan Kettering Cancer Center

NCT00002711

COMPLETED NA 24 participants

Pain Management Smartphone Application for Patients With Stage III-IV Head and Neck Cancer Undergoing Radiation Therapy

Vanderbilt-Ingram Cancer Center

NCT02324881

COMPLETED Phase 1 23 participants

M1231 in Participants With Solid Tumors

EMD Serono Research & Development Institute

NCT04695847

COMPLETED 19 participants

Is Screening for Esophageal Pathology in Asymptomatic Patients Post-Treatment for Head and Neck Cancer Beneficial?

University of California, Davis

NCT00583934

COMPLETED Phase 1 17 participants

Trial of XELOX Followed by Radiation Combined With Carboplatin and RAD001 for Esophageal Cancer

Emory University

NCT01490749

COMPLETED Phase 1 13 participants

Combination Chemotherapy and Radiation Therapy in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer

Duke University

NCT00281788

COMPLETED Phase 1 12 participants

Epigenetic Priming Using Azacitidine With Neoadjuvant Chemotherapy for Resectable Esophageal Cancer

Weill Medical College of Cornell University

NCT01386346

COMPLETED Phase 1 10 participants

NIR-Guided Sentinel Lymph-Node Mapping for Esophageal Cancer

Dana-Farber Cancer Institute

NCT01808417

COMPLETED NA 10 participants

Clinical Study to Evaluate CryoBalloon™ Full and Swipe Ablation Systems for Ablation of Human Esophageal Epithelium

Pentax Medical

NCT02729753

COMPLETED Phase 4 7 participants

Study of CryoSpray Ablation(TM)to Determine Treatment Effect, Depth of Injury, and Side Effects in the Esophagus.

CSA Medical

NCT00754468

COMPLETED Phase 2

Erlotinib in Treating Patients With Locally Advanced or Metastatic Stomach Cancer or Gastroesophageal Junction Cancer

SWOG Cancer Research Network

NCT00032123

COMPLETED Phase 2

BMS-247550 in Treating Patients With Metastatic Stomach Cancer Previously Treated With Chemotherapy

Bristol-Myers Squibb

NCT00017043

COMPLETED Phase 1

Oxaliplatin and Fluorouracil Plus Radiation Therapy in Treating Patients With Primary Esophageal or Stomach Cancer

Albany Medical College

NCT00004257

COMPLETED Phase 2

Flavopiridol and Paclitaxel in Treating Patients With Locally Advanced or Metastatic Esophageal Cancer That Has Not Responded to Previous Paclitaxel

Memorial Sloan Kettering Cancer Center

NCT00006245

COMPLETED Phase 2

DX-8951f in Treating Patients With Metastatic Stomach Cancer

Daiichi Sankyo

NCT00017212

COMPLETED Phase 2

Combination Chemotherapy Plus Radiation Therapy With or Without Fluorouracil in Treating Patients With Cancer of the Esophagus or Stomach

Radiation Therapy Oncology Group

NCT00009880

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Phase Distribution

PhaseTrial count
Phase 1 49
Phase 2 35
Phase 3 5
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Esophageal Cancer Trial Landscape

132 indexed Esophageal Cancer studies · 63 recruiting (48%).

Phase mix: 8 late (III/IV) vs 84 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (10 trials), 9 others listed. 32 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Esophageal Cancer?

PlainTrial tracks 132 US clinical trials for Esophageal Cancer, of which 63 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Esophageal Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.