Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06692400 · ClinicalTrials.gov registry record · NA
The Effects of Endotracheal Suctioning on Pain and Serum Markers
A NA study of Critical Illness and Hypoxia, sponsored by Loma Linda University.
- Recruiting
- Registry status
- NA
- Development phase
- 110
- Enrollment target
- 1
- Study location
NCT06692400: Recruiting NA study of Critical Illness and Hypoxia, sponsored by Loma Linda University.
NCT06692400 is a NA study of Critical Illness and Hypoxia that is actively recruiting participants, run by Loma Linda University. The registered enrollment target is 110 participants, below the 3,137-participant average among 91 other Critical Illness trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06692400, a NA study of Critical Illness and Hypoxia, is actively recruiting participants, sponsored by Loma Linda University.
- RECRUITING
- Registry status
- NA
- Development phase
- 110 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be uncomfortable and cause stress. The main questions this study aims to answer are: Does ETT suctioning raise pain levels as measured by the Critical-Care Pain Observation Tool (CPOT)? Does ETT suctioning increase certain chemicals in the blood (hypoxanthine, xanthine, and uric acid) that show stress and lack of oxygen in the body? Researchers will compare patients who have ETT suctioning (intervention group) with those who do not have suctioning during the study period (control group) to see if there are differences in pain and blood markers of stress. Participants will: Have pain measured before and after suctioning using the CPOT. Have blood samples taken from an existing line at three time points: 5 minutes before, 5 minutes after, and 30 minutes after suctioning. Provide demographic information (like age, gender, and diagnosis) from medical records. This research will help improve how pain is managed for ICU patients who cannot speak for themselves, potentially leading to better pain relief methods in the future.
Primary Outcome
The Critical-Care Pain Observation Tool (CPOT) is a composite measurement used to assess pain in non-verbal ICU patients by evaluating four behavioral indicators: facial expression, body movements, muscle tension, and ventilator compliance (for intubated patients) or vocalization (for non-intubated patients). Each indicator is scored from 0 (no pain behavior) to 2 (intense pain behavior), resulting in a total score from 0 to 8. Higher scores indicate higher pain levels, guiding clinicians in pai
Conditions Studied
Interventions
- PROCEDURE endotracheal tube suctioning
Study Locations (1)
California
- Loma Linda University Medical Center Troesh Medical Campus - Loma Linda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 110 participants |
| Start Date | 2025-01-30 |
| Est. Completion | 2026-04 |
| Phase | NA |
What NCT06692400 shows while recruiting
NCT06692400 is an interventional study that assigns participants to a tested intervention. The registered 110 participants enrollment target is mid-sized for trials with a published cap, below the 3,137-participant average among 91 other Critical Illness trials with a reported enrollment target (96% lower).
The record links to 10 conditions, with Critical Illness appearing as the primary indexed condition, and to 1 intervention - of which endotracheal tube suctioning is the first listed.
NCT06692400 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06692400 about?
NCT06692400 is a clinical study titled "The Effects of Endotracheal Suctioning on Pain and Serum Markers". The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be ...
What is the current status of trial NCT06692400?
This trial is currently recruiting. It is a NA study. The enrollment target is 110 participants. The study started on 2025-01-30. Estimated completion is 2026-04.
What conditions does trial NCT06692400 study?
This clinical trial studies the following conditions: Critical Illness, Hypoxia, Oxidative Stress, Mechanical Ventilation, Adult.
What interventions are being tested in trial NCT06692400?
The interventions under investigation include: endotracheal tube suctioning (PROCEDURE).
Who is sponsoring clinical trial NCT06692400?
This trial is sponsored by Loma Linda University, which has 237 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06692400 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Critical Illness
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06692400's enrollment target sits among peer trials
110 61st of 91 higher than 31 of 91 other Critical Illness trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Critical Illness trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Preoperative Fasting vs. Not Fasting in Critically Ill Patients
RECRUITING · NA
-
Improving Needs Among Older Adults
RECRUITING · NA
-
The Family Perspectives Project Pilot Trial
RECRUITING · NA
-
12-hour Time Limited Feeding in Critical Care
RECRUITING · NA
-
PUSH-IT Continuing Enteral Feeds for Tracheostomy
RECRUITING · NA
-
Reestablishing Sleep and Circadian Alignment in Medical Intensive Care Unit (MICU) Patients Via a Mechanistic RCT of an Sleep Chronobundle
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01530373 · 110 participants · Phase 2
Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients
- NCT02379377 · 110 participants · Phase 1
18F-FSPG PET in Imaging Patients With Liver Cancer Before Undergoing Surgery or Transplant
- NCT02411773 · 110 participants · Phase 1
Sympatholysis in Chronic Kidney Disease
- NCT03190941 · 110 participants · Phase 1
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI