Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Critical Illness: full-pipeline trial registry
41 of 92 indexed Critical Illness trials are currently recruiting.
Corpus placement: #148 of 28,707 conditions by registered trial count.
92 US clinical trials · 41 currently recruiting · #148 of 28,707 conditions by registered trial count
Critical Illness: 92 US clinical trials tracked, 41 recruiting.
Critical Illness is the subject of 92 registered US clinical trials on ClinicalTrials.gov, 41 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Vanderbilt University Medical Center, running 6 of these trials.
Enrollment posture brief
Registry condition critical-illness
OPEN 41 | RECR 45% | LATE 6 | EARLY 8 | RANK #148 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Hepatocellular Carcinoma (45% recruiting · 146 trials)
Critical Illness lists 41 open slots (45% of 92 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Critical Illness on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Critical Illness is recruiting above its size-band peers.
41 of 92 indexed trials (44.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Critical Illness trials is spread across many organizations.
Vanderbilt University Medical Center accounts for 6 of 92 trials (6.5%). 52 distinct sponsors appear on at least one study for this condition label.
-
Typical Critical Illness enrolment sits around 250 participants.
Median target enrolment is 250 among the 92 trials that report a genuine target (sentinel values excluded). 24 of those (26.1%) plan for fewer than 100 participants.
-
Critical Illness research is mostly interventional.
70 interventional and 22 observational studies make up this index (76.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
92 total, page 2 of 2
Long Term Outcomes of Patients With COVID-19
University of Chicago
NCT04360538
Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned After Hospitalization in Trauma-ICU Study
Vanderbilt University Medical Center
NCT03098459
Measuring Outcomes of Activity in Intensive Care
Vanderbilt University Medical Center
NCT03115840
Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention
University of Colorado, Denver
NCT06374225
Assessing The Effects of Exercise, Protein, and Electric Stimulation On Intensive Care Unit Patients Outcomes
University of Maryland, Baltimore
NCT02509520
Optimal Timing of Computerized Cognitive Training for Older Intensive Care Unit Survivors
University of Washington
NCT05467410
Driving Rehabilitation and Innovation for Evaluating Risk in Post-Intensive Care Unit Survivors
Baylor Research Institute
NCT05999903
Saline Against Lactated Ringers or Plasmalyte in the Emergency Department
Vanderbilt University
NCT02614040
Isotonic Solutions and Major Adverse Renal Events Trial in the Non-Medical Intensive Care Unit (SMART-SURG)
Vanderbilt University
NCT02547779
Understanding Community Considerations, Opinions, Values, Impacts, and Decisions for COVID-19
University of California, Los Angeles
NCT04373135
Study of Therapeutic Exercise in Acute Respiratory Failure to Improve Neuromuscular Disability Trial
University of Pennsylvania
NCT03863470
The Effect of Higher Protein Dosing in Critically Ill Patients
Clinical Evaluation Research Unit at Kingston General Hospital
NCT03160547
Oral Care to Reduce Mouth and Throat Infections in Critically Ill Patients
National Institutes of Health Clinical Center (CC)
NCT00078663
Supplemental Enteral Protein in Critical Illness
University of Washington
NCT03170401
Improving Family Meetings in the Pediatric Cardiac Intensive Care Unit
Children's Hospital of Philadelphia
NCT03749330
Wake Forest Post-ICU Telehealth (WFIT) Program
Wake Forest University Health Sciences
NCT04576065
Daily Sedative Interruption in Critically Ill Patients Being Managed With a Sedation Protocol.
Mount Sinai Hospital, Canada
NCT00675363
Family Presence on Multidisciplinary Patient Care Rounds in ICU
Rutgers, The State University of New Jersey
NCT05449990
Effect of Intensivist Communication on Surrogate Prognosis Interpretation
Johns Hopkins University
NCT04239209
The Clinical Informationist: Does the Model Work
Vanderbilt University
NCT00226291
Pediatric Continuity Care Intensivist
Children's Hospital of Philadelphia
NCT02146573
Hypovitaminosis D in Neurocritical Patients
University of Utah
NCT02881957
Psychological Support Based on Positive Suggestions (PSBPS) on Mental Health Morbidity and Cognitive Function
Mayo Clinic
NCT04045210
Ultrasound Measurement of Reactive Hyperemia in Critical Care
University of Rochester
NCT01726595
Time Limited Trials to Reduce Non-Beneficial Intensive Care Unit Treatments
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
NCT04181294
A Needs-focused Palliative Care Intervention for Older Adults in ICUs
Duke University
NCT04414787
Efficacy and Mechanisms of GLN Dipeptide in the SICU
Emory University
NCT00248638
The Diagnosis and Incidence of Critical Illness Polyneuromyopathy in Medical and Neurosurgical ICU Patients
University of Colorado, Denver
NCT02634658
Assessing the Impact of LIve Music in the Intensive Care Unit (ICU) to Improve Care for Critically Ill Patients
Vanderbilt University Medical Center
NCT03948984
Anticipating Decline and Providing Therapy
Wake Forest University Health Sciences
NCT06182995
Practical Anemia Bundle for SusTained Blood Recovery
Mayo Clinic
NCT05167734
Inulin for Infections in the Intensive Care Unit
Columbia University
NCT03865706
Using Ultrasound to Study Respiratory Muscle Function in Critically Ill Patients
Wake Forest University Health Sciences
NCT03139695
Post-ICU Palliative Care Intervention (PIPCI) Trial
Columbia University
NCT03456323
Novel Arm Restraint For Critically Ill Patients To Reduce Immobility, Sedation, Agitation and Cognitive Impairment
University of Vermont
NCT04067622
Tolerance and Efficacy of a Predigested, High Protein, High Omega 3 Fat Enteral Feeding Formula Versus a Standard Formula In Multiple Intensive Care Unit Settings
Columbia University
NCT01448135
Methionine Metabolism in Enterally Fed Pediatric Sepsis
The Cleveland Clinic
NCT01889264
Personalized Nutrition Delivery to Improve Resilience in Older Adult Trauma Patients
Duke University
NCT05544162
Intraosseous Catheter Confirmation Study
Rutgers, The State University of New Jersey
NCT03908879
Optimizing Outcomes With Physical Therapy Treatment for IndividuALs Surviving an ICU Admission for Covid-19
University of Kentucky
NCT04412330
Comparing Cardiac Output Measurements in Critically Ill Children Using USCOM and Transthoracic ECHO
University of North Carolina, Chapel Hill
NCT01460329
Feasibility of Upright Bed Position in ARDS Patients
Wake Forest University Health Sciences
NCT02160561
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 5 |
| Phase 3 | 6 |
Top Sponsors
Named interventions
Most-linked intervention names on Critical Illness records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Critical Illness trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Critical Illness page
92 registered trials, 41 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 41 Critical Illness trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Vanderbilt University Medical Center sponsors the most Critical Illness trials on record, review their full trial history before evaluating a specific study. See Vanderbilt University Medical Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Critical Illness condition card totals 92 registered trials; most-linked intervention Physiologically-balanced isotonic crystalloid; top US site state North Carolina. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.