Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Preoperative Fasting vs. Not Fasting in Critically Ill Patients
NCT06751043 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this clinical trial is to learn if fasting or not fasting before a procedure has an effect on recovery in those who are critically ill. The main questions it aims to answer for patients on a breathing machine who are receiving tube feeding are: * Does the risk of lung complications and death differ between those who are not fasting, which may have a higher chance of allowing tube feeding to enter the lungs, and fasting, which temporarily stops nutrition before a procedure? * Is there a difference in recovery times, hospital stays, infection rates, need for organ support, safety, and nutrition for those who either fast or do not fast before a procedure? * What is the relationship between nutrition and clinical outcomes? Researchers will compare not fasting and fasting to see if it has an effect on recovery. Participants will: * Be assigned by chance (like a coin toss) to one of two groups. One group (fasting group) will have their tube feeding stopped at least 8 hours before their procedure. The other group (not fasting group) will have their tube feeding stopped right before their procedure. * Be monitored via medical record for amount of protein and calories received, and any complications related to fasting/not fasting. * Receive a phone call from the study team about 3 months after they enter the study to see how they are doing and complete a questionnaire. '
Conditions Studied
Interventions
- OTHER Fasting
- OTHER Not fasting
Study Locations (19)
New York
- Columbia University Irvine Medical Center — New York
- Memorial Sloan Kettering Cancer Center — New York
- University of Rochester Medical Center — Rochester
- Montefiore Medical Center — The Bronx
Massachusetts
- Mass General Hospital — Boston
- Brigham & Women's Hospital — Boston
- University of Massachusetts Memorial Medical Center — Worcester
California
- Stanford Medical Center — Palo Alto
- UCSF Medical Center Parnassus — San Francisco
Illinois
- McGaw Medical Center of Northwestern — Chicago
- Rush University Medical Center — Chicago
Texas
- University of Texas Medical Branch — Galveston
- UT Health Houston — Houston
Colorado
- University of Colorado Medical Center — Aurora
Florida
- University of Miami Hospital — Miami
Maryland
- University of Maryland Medical Center — Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,072 participants |
| Start Date | 2025-04-28 |
| Est. Completion | 2028-05 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06751043
The ClinicalTrials.gov registry entry for NCT06751043 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,072 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Massachusetts General Hospital, which has 1,948 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Critical Illness appearing as the primary indexed condition, and to 2 interventions — of which Fasting is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06751043 reports 19 study locations spanning 11 distinct geographic areas — top geographies include New York, Massachusetts, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06751043 about?
NCT06751043 is a clinical study titled "Preoperative Fasting vs. Not Fasting in Critically Ill Patients". The goal of this clinical trial is to learn if fasting or not fasting before a procedure has an effect on recovery in those who are critically ill. The main questions it aims to answer for patients on a breathing machine who are receiving tube feeding are: * Does the risk of lung complications and ...
What is the current status of trial NCT06751043?
This trial is currently recruiting. It is a NA study. The enrollment target is 1,072 participants. The study started on 2025-04-28. Estimated completion is 2028-05.
What conditions does trial NCT06751043 study?
This clinical trial studies the following conditions: Critical Illness, Fasting, Surgical Procedure, Unspecified, Pulmonary Aspiration. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06751043?
The interventions under investigation include: Fasting (OTHER), Not fasting (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06751043?
This trial is sponsored by Massachusetts General Hospital, which has 1,948 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06751043 being conducted?
This trial has 19 study locations across California, Colorado, Florida, Illinois, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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