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The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma
NCT06606119 · View on ClinicalTrials.gov ↗
Study Summary
Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic inflammation, bone marrow dysfunction, and an altered microbiome which will provide a strong foundation for future clinical interventions to help improve outcomes following severe trauma.
Conditions Studied
Interventions
- OTHER Data and tissue collection
Study Locations (3)
Florida
- UF Academic Research Building — Gainesville
- UF Health at Shands Hospital — Gainesville
- UF Laboratory of Inflammation Biology and Surgical Science and Shands Hospital at UF — Gainesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 275 participants |
| Start Date | 2025-01-24 |
| Est. Completion | 2028-10-01 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06606119
The ClinicalTrials.gov registry entry for NCT06606119 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 275 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Florida, which has 1,066 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 6 conditions, with Critical Illness appearing as the primary indexed condition, and to 1 intervention — of which Data and tissue collection is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06606119 reports 3 study locations spanning 1 distinct geographic area — top geographies include Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06606119 about?
NCT06606119 is a clinical study titled "The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma". Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic infla...
What is the current status of trial NCT06606119?
This trial is currently recruiting. The enrollment target is 275 participants. The study started on 2025-01-24. Estimated completion is 2028-10-01.
What conditions does trial NCT06606119 study?
This clinical trial studies the following conditions: Critical Illness, Trauma, Trauma Injury, Microbiome, Acute Blood Loss Anemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06606119?
The interventions under investigation include: Data and tissue collection (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06606119?
This trial is sponsored by University of Florida, which has 1,066 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06606119 being conducted?
This trial has 3 study locations across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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