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NCT06578468 · ClinicalTrials.gov registry record · NA
End-Tidal Oxygen for Intubation in the Emergency Department
A NA study of Critical Illness and Respiratory Failure, sponsored by Sydney Local Health District.
- Recruiting
- Registry status
- NA
- Development phase
- 1,400
- Enrollment target
- 9
- Study locations
NCT06578468: Recruiting NA study of Critical Illness and Respiratory Failure, sponsored by Sydney Local Health District.
NCT06578468 is a NA study of Critical Illness and Respiratory Failure that is actively recruiting participants, run by Sydney Local Health District. The registered enrollment target is 1,400 participants, below the 3,123-participant average among 91 other Critical Illness trials with a reported enrollment target (55% lower). The trial reports 9 study locations across 5 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06578468, a NA study of Critical Illness and Respiratory Failure, is actively recruiting participants, sponsored by Sydney Local Health District.
- RECRUITING
- Registry status
- NA
- Development phase
- 1,400 participants
- Enrollment target
- 9
- Study locations
Study Summary
Rapid Sequence Intubation (RSI) is a high-risk procedure in the emergency department (ED). Patients are routinely preoxygenated (given supplemental oxygen) prior to RSI to prevent hypoxia during intubation. For many years anaesthetists have used end-tidal oxygen (ETO2) levels to guide the effectiveness of preoxygenation prior to intubation. The ETO2 gives an objective measurement of preoxygenation efficacy. This is currently not available in most EDs. This trial evaluates the use of ETO2 on the rate of hypoxia during intubation for patients in the ED.
Primary Outcome
The proportion of patients that experience oxygenation desaturation (SpO2 \<93%, or \>10% from baseline if SpO2 \<93% at the end of preoxygenation) during the peri-intubation period
Conditions Studied
Interventions
- DEVICE End-tidal oxygen monitor
Study Locations (9)
New South Wales
- Westmead Hospital - Sydney
- Royal Prince Alfred Hospital - Sydney
- Liverpool Hospital - Sydney
- Northern Beaches Hospital - Sydney
- Royal North Shore Hospital - Sydney
Minnesota
- Hennepin Medical Center - Minneapolis
New Mexico
- University of New Mexico Medical Center - Albuquerque
New York
- Lincoln Medical Center - The Bronx
Victoria
- The Alfred Hospital - Melbourne
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,400 participants |
| Start Date | 2024-08-05 |
| Est. Completion | 2025-12-31 |
| Phase | NA |
What NCT06578468 shows while recruiting
NCT06578468 is an interventional study that assigns participants to a tested intervention. Its 1,400 participants enrollment target places it among the larger protocols in the corpus, below the 3,123-participant average among 91 other Critical Illness trials with a reported enrollment target (55% lower).
The record links to 3 conditions, with Critical Illness appearing as the primary indexed condition, and to 1 intervention - of which End-tidal oxygen monitor is the first listed.
NCT06578468 lists 9 locations in 5 states (New South Wales, Minnesota, New Mexico).
Frequently Asked Questions
What is clinical trial NCT06578468 about?
NCT06578468 is a clinical study titled "End-Tidal Oxygen for Intubation in the Emergency Department". Rapid Sequence Intubation (RSI) is a high-risk procedure in the emergency department (ED). Patients are routinely preoxygenated (given supplemental oxygen) prior to RSI to prevent hypoxia during intubation. For many years anaesthetists have used end-tidal oxygen (ETO2) levels to guide the effectiven...
What is the current status of trial NCT06578468?
This trial is currently recruiting. It is a NA study. The enrollment target is 1,400 participants. The study started on 2024-08-05. Estimated completion is 2025-12-31.
What conditions does trial NCT06578468 study?
This clinical trial studies the following conditions: Critical Illness, Respiratory Failure, Hypoxia.
What interventions are being tested in trial NCT06578468?
The interventions under investigation include: End-tidal oxygen monitor (DEVICE).
Who is sponsoring clinical trial NCT06578468?
This trial is sponsored by Sydney Local Health District, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06578468 being conducted?
This trial has 9 study locations across Minnesota, New Mexico, New York, New South Wales, Victoria. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06578468's enrollment target sits among peer trials
1,400 15th of 91 higher than 76 of 91 other Critical Illness trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Critical Illness trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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