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NCT06411561 · ClinicalTrials.gov registry record · NA

A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

A NA study of Dementia and Alzheimers Disease, sponsored by University of Washington.

Recruiting
Registry status
NA
Development phase
100
Enrollment target
1
Study location

NCT06411561: Recruiting NA study of Dementia and Alzheimers Disease, sponsored by University of Washington.

NCT06411561 is a NA study of Dementia and Alzheimers Disease that is actively recruiting participants, run by University of Washington. The registered enrollment target is 100 participants, below the 7,722-participant average among 199 other Dementia trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT06411561, a NA study of Dementia and Alzheimers Disease, is actively recruiting participants, sponsored by University of Washington.

RECRUITING
Registry status
NA
Development phase
100 participants
Enrollment target
1
Study location

Study Summary

Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which contribute to higher risk for cognitive decline related to Alzheimer's disease and related dementias. Sleep and activity are essential for recovery from critical illness, yet ICU survivors experience both sleep deficiency and profound inactivity. About 75-80% of ICU patients experience circadian dysrhythmia, which contributes to cognitive decline and increases likelihood of developing Alzheimer's disease and related dementias. The scientific premises of the proposed study are: 1) a combined sleep promotion and cognitive training intervention will have synergistic effects to mitigate the risk of cognitive impairment and development of Alzheimer's disease and related dementias in older ICU survivors; and 2) chronotherapeutic timing of interventions (i.e., adjusting timing of interventions according to circadian rhythm) may improve intervention efficacy.

Primary Outcome

RBANS Update: Repeatable Battery for the Assessment of Neuropsychological Status; total index score, range: 40-160; higher scores indicate better performance

Conditions Studied

Dementia Alzheimers Disease Cognitive Impairment Critical Illness Delirium Cognitive Decline Sleep Disturbance Circadian Dysrhythmia

Interventions

  • BEHAVIORAL SLEEP + COG
  • BEHAVIORAL COG
  • BEHAVIORAL SLEEP
  • BEHAVIORAL AC

Study Locations (1)

Washington

  • University of Washington - Seattle

Trial Details

FieldValue
Enrollment Target 100 participants
Start Date 2024-12-26
Est. Completion 2027-05-31
Phase NA
University of Washington

1,048 total trials

What NCT06411561 shows while recruiting

NCT06411561 is an interventional study that assigns participants to a tested intervention. The registered 100 participants enrollment target is mid-sized for trials with a published cap, below the 7,722-participant average among 199 other Dementia trials with a reported enrollment target (99% lower).

The record links to 8 conditions, with Dementia appearing as the primary indexed condition, and to 4 interventions - of which SLEEP + COG is the first listed.

NCT06411561 reports a single indexed study location in Washington.

Frequently Asked Questions

What is clinical trial NCT06411561 about?

NCT06411561 is a clinical study titled "A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors". Up to 25% of intensive care unit (ICU) survivors experience cognitive impairment comparable in severity to mild Alzheimer's disease and related dementias after hospital discharge. Older ICU survivors (ages 60 and older) are at highest risk for delirium and subsequent cognitive impairment, which cont...

What is the current status of trial NCT06411561?

This trial is currently recruiting. It is a NA study. The enrollment target is 100 participants. The study started on 2024-12-26. Estimated completion is 2027-05-31.

What conditions does trial NCT06411561 study?

This clinical trial studies the following conditions: Dementia, Alzheimers Disease, Cognitive Impairment, Critical Illness, Delirium.

What interventions are being tested in trial NCT06411561?

The interventions under investigation include: SLEEP + COG (BEHAVIORAL), COG (BEHAVIORAL), SLEEP (BEHAVIORAL), AC (BEHAVIORAL).

Who is sponsoring clinical trial NCT06411561?

This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06411561 being conducted?

This trial has 1 study location across Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Dementia

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT06411561's enrollment target sits among peer trials

100 118th of 199 higher than 80 of 199 other Dementia trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Dementia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT06411561

Source: ClinicalTrials.gov NCT06411561, the US trial registry maintained by the National Library of Medicine. NCT06411561 (mid enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.