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FOG-001 in Locally Advanced or Metastatic Solid Tumors
NCT05919264 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this clinical trial is to determine if FOG-001 is safe and effective in participants with locally advanced or metastatic cancer.
Conditions Studied
Interventions
- DRUG Bevacizumab
- DRUG Nivolumab
- DRUG FOG-001
- DRUG mFOLFOX-6
- DRUG Trifluridine/tipiracil
Study Locations (20)
California
- Stanford Cancer Institute, Stanford University — Palo Alto
- University of California San Francisco, Helen Diller Family Comprehensive Cancer Center — San Francisco
- Sarcoma Oncology Center — Santa Monica
Arizona
- Honor Health — Scottsdale
- Arizona Cancer Center at University of Arizona — Tucson
Massachusetts
- Massachusetts General Hospital — Boston
- Dana Farber Cancer Institute — Boston
Ohio
- University Hospitals Cleveland Medical Center, Seidman Cancer Center — Cleveland
- Cleveland Clinic — Cleveland
Connecticut
- Yale University School of Medicine — New Haven
District of Columbia
- Johns Hopkins University, Sibley Memorial Hospital — Washington D.C.
Florida
- Florida Cancer Specialists — Lake Mary
Maryland
- Johns Hopkins University, The Sidney Kimmel Comprehensive Cancer Center — Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 575 participants |
| Start Date | 2023-05-23 |
| Est. Completion | 2027-08-31 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05919264
The ClinicalTrials.gov registry entry for NCT05919264 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 575 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Parabilis Medicines, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 10 conditions, with Cancer appearing as the primary indexed condition, and to 5 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05919264 reports 20 study locations spanning 15 distinct geographic areas — top geographies include California, Arizona, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05919264 about?
NCT05919264 is a clinical study titled "FOG-001 in Locally Advanced or Metastatic Solid Tumors". The goal of this clinical trial is to determine if FOG-001 is safe and effective in participants with locally advanced or metastatic cancer.
What is the current status of trial NCT05919264?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 575 participants. The study started on 2023-05-23. Estimated completion is 2027-08-31.
What conditions does trial NCT05919264 study?
This clinical trial studies the following conditions: Cancer, Colorectal Cancer, Solid Tumor, Metastatic Cancer, Locally Advanced Solid Tumor. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05919264?
The interventions under investigation include: Bevacizumab (DRUG), Nivolumab (DRUG), FOG-001 (DRUG), mFOLFOX-6 (DRUG), Trifluridine/tipiracil (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05919264?
This trial is sponsored by Parabilis Medicines, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05919264 being conducted?
This trial has 20 study locations across Arizona, California, Connecticut, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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