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Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
NCT06445062 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors combined with Standard(s) of Care (SOC) or with novel agents. The current subprotocols include the following: Subprotocol A: RMC-6236 + 5-fluorouracil-based regimens Subprotocol B: RMC-6236 + cetuximab with or without mFOLFOX6 Subprotocol C: RMC-6236 + gemcitabine + nab-paclitaxel Subprotocol D: RMC-9805 with or without RMC-6236 + 5-fluorouracil-based regimens Subprotocol E: RMC-9805 with or without RMC-6236 + cetuximab with or without mFOLFOX6 Subprotocol F: RMC-9805 with or without RMC-6236 + gemcitabine + nab-paclitaxel
Conditions Studied
Interventions
- DRUG cetuximab
- DRUG RMC-6236
- DRUG bevacizumab
- DRUG mFOLFOX6 regimen
- DRUG mFOLFIRINOX regimen
Study Locations (20)
Arizona
- Ironwood Cancer and Research Centers — Chandler
- Mayo Clinic Hospital — Phoenix
- HonorHealth Research Institute — Scottsdale
California
- UC San Diego Moores Cancer Center — La Jolla
- Cedars-Sinai Cancer at Cedars-Sinai Medical Center — Los Angeles
- UCLA Hematology/Oncology- Santa Monica — Los Angeles
Florida
- Mayo Clinic Cancer Center — Jacksonville
- Moffitt Cancer Center — Tampa
Massachusetts
- Massachusetts General Hospital — Boston
- Dana Farber Cancer Institute — Boston
Nebraska
- Nebraska Cancer Specialists — Omaha
- University of Nebraska Medical Center — Omaha
New York
- Northwell Health / RJ Zuckerberg Cancer Center — Lake Success
- Columbia University Medical Center — New York
Colorado
- University of Colorado Hospital-Anschutz Cancer Pavilion — Aurora
Connecticut
- Yale-New Haven Hospital-Yale Cancer Center — New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,130 participants |
| Start Date | 2024-05-24 |
| Est. Completion | 2027-07-15 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06445062
The ClinicalTrials.gov registry entry for NCT06445062 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,130 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Revolution Medicines, which has 66 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 6 conditions, with Colorectal Cancer appearing as the primary indexed condition, and to 5 interventions — of which cetuximab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06445062 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Arizona, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06445062 about?
NCT06445062 is a clinical study titled "Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors". The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors combined with Standard(s) of Care (SOC) or with novel agents. The current subprotocols include the following: Subprotocol A: RMC-6236 + ...
What is the current status of trial NCT06445062?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 1,130 participants. The study started on 2024-05-24. Estimated completion is 2027-07-15.
What conditions does trial NCT06445062 study?
This clinical trial studies the following conditions: Colorectal Cancer, Pancreatic Ductal Adenocarcinoma, Gastrointestinal Cancer, Metastatic Pancreatic Ductal Adenocarcinoma, CRC. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06445062?
The interventions under investigation include: cetuximab (DRUG), RMC-6236 (DRUG), bevacizumab (DRUG), mFOLFOX6 regimen (DRUG), mFOLFIRINOX regimen (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06445062?
This trial is sponsored by Revolution Medicines, which has 66 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06445062 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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