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RECRUITING Phase 1

MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

NCT06586515 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to assess safety \& tolerability and antitumor activity of LY3962673 as monotherapy and in combination with other chemotherapy agents in participants with KRAS G12D-mutant advanced solid tumor types. The study is expected to last approximately 5 years.

Interventions

  • DRUG Oxaliplatin
  • DRUG Cetuximab
  • DRUG Gemcitabine
  • DRUG nab-paclitaxel
  • DRUG LY3962673

Study Locations (20)

Tennessee

  • Sarah Cannon Research Institute — Nashville
  • USO - US Oncology Research Network — Nashville
  • Vanderbilt University School of Medicine — Nashville

California

  • City of Hope — Duarte
  • University of California, Los Angeles (UCLA) — Los Angeles

Massachusetts

  • Massachusetts General Hospital — Boston
  • Dana-Farber Cancer Institute — Boston

Michigan

  • Barbara Ann Karmanos Cancer Institute — Detroit
  • South Texas Accelerated Research Therapeutics (START) Midwest — Grand Rapids

New York

  • New York University (NYU) Langone Medical Center — New York
  • David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center — New York

Ohio

  • University of Cincinnati (UC) - Cancer Institute — Cincinnati
  • Cleveland Clinic — Cleveland

Colorado

  • Sarah Cannon Research Institute at HealthOne — Denver

District of Columbia

  • Sibley Memorial Hospital — Washington D.C.

Trial Details

FieldValue
Enrollment Target 630 participants
Start Date 2024-09-12
Est. Completion 2029-03
Phase Phase 1

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06586515

The ClinicalTrials.gov registry entry for NCT06586515 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 630 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Colorectal Cancer appearing as the primary indexed condition, and to 5 interventions — of which Oxaliplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06586515 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Tennessee, California, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06586515 about?

NCT06586515 is a clinical study titled "MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors". The main purpose of this study is to assess safety \& tolerability and antitumor activity of LY3962673 as monotherapy and in combination with other chemotherapy agents in participants with KRAS G12D-mutant advanced solid tumor types. The study is expected to last approximately 5 years.

What is the current status of trial NCT06586515?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 630 participants. The study started on 2024-09-12. Estimated completion is 2029-03.

What conditions does trial NCT06586515 study?

This clinical trial studies the following conditions: Colorectal Cancer, Non-small Cell Lung Cancer, Pancreatic Ductal Adenocarcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06586515?

The interventions under investigation include: Oxaliplatin (DRUG), Cetuximab (DRUG), Gemcitabine (DRUG), nab-paclitaxel (DRUG), LY3962673 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06586515?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06586515 being conducted?

This trial has 20 study locations across California, Colorado, District of Columbia, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial