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Colorectal Cancer: early-phase trial registry
154 of 382 indexed Colorectal Cancer trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #14 of 28,963 conditions by registered trial count.
382 US clinical trials · 154 currently recruiting · #14 of 28,963 conditions by registered trial count
Colorectal Cancer: 382 US clinical trials tracked, 154 recruiting.
Colorectal Cancer is the subject of 382 registered US clinical trials on ClinicalTrials.gov, 154 of them currently open to new participants. 12 are in Phase 3-4 (later-stage) and 196 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 22 of these trials.
Open enrollment, early-phase tilt
Colorectal Cancer has 382 registered US clinical trials, 154 of them open to new participants right now, about 40% of the total.
- 154
- recruiting participants now
- 40%
- of trials open to enrollment
- 12
- in Phase 3-4 (later-stage)
- 22
- top sponsor: Memorial Sloan Kettering Cancer Center
Corpus placement: #14 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Colorectal Cancer on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
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Colorectal Cancer is recruiting above its size-band peers.
154 of 382 indexed trials (40.3%) are open to enrollment, against a 37.2% average across 135 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Colorectal Cancer trials is spread across many organizations.
Memorial Sloan Kettering Cancer Center accounts for 22 of 382 trials (5.8%). 217 distinct sponsors appear on at least one study for this condition label.
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Typical Colorectal Cancer enrolment sits around 132 participants.
Median target enrolment is 132 among the 370 trials that report a genuine target (sentinel values excluded). 157 of those (42.4%) plan for fewer than 100 participants.
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Colorectal Cancer research is mostly interventional.
315 interventional and 67 observational studies make up this index (82.5% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
382 total, page 2 of 8
Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays
Tempus AI
NCT05234177
Locally ablatIVe thErapy for oLigo-progressive gastrOintestiNal maliGnancies (LIVELONG)
University of California, Davis
NCT06101277
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
Verastem
NCT07020221
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
Bicara Therapeutics
NCT04429542
A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy
Memorial Sloan Kettering Cancer Center
NCT07227636
A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors
Pfizer
NCT07318805
Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors
Duke University
NCT06371768
Safety and Effectiveness Evaluation of the COLO-BT as an Alternative Treatment to the Ileostomy
JSR Medical Co.
NCT05826743
Time-restricted Eating Versus Daily Continuous Calorie Restriction on Body Weight and Colorectal Cancer Risk Markers
University of Illinois at Chicago
NCT05114798
A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
A2 Biotherapeutics
NCT06682793
Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers
Udai Kammula
NCT03935893
Implementing a Randomized Control Trial to Test the Expanded Web-based Decision Aid
Washington University School of Medicine
NCT06910670
The Care Tracker Study: Using Patient-Reported Data to Address Racial Disparity in Cancer Treatment
UNC Lineberger Comprehensive Cancer Center
NCT06096623
Mediterranean Diet and Weight Loss: Targeting the Bile Acid/Gut Microbiome Axis to Reduce Colorectal Cancer
University of Illinois at Chicago
NCT04753359
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Merck Sharp & Dohme
NCT06428409
BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours
Bold Therapeutics
NCT04421820
A Study to Assess IPN01194 When Administered Alone in Adults With Advanced Solid Tumours
Ipsen
NCT06305247
A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors
IDEAYA Biosciences
NCT05787587
Tumor-Derived FGF19
University of Central Florida
NCT06068257
Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer
National Cancer Institute (NCI)
NCT06253520
A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer
Sutro Biopharma
NCT07227168
Anti-CEACAM5 ADC M9140 in Advanced Solid Tumors (PROCEADE-CRC-01)
EMD Serono Research & Development Institute
NCT05464030
Splicing-based Predictive Learning for Individual Chemotherapy Evaluation in Colorectal Cancer
City of Hope Medical Center
NCT07226115
Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing
A2 Biotherapeutics
NCT04981119
A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors
Jazz Pharmaceuticals
NCT06695845
Walnuts and Colon Health
UConn Health
NCT05195970
A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors
PAQ Therapeutics
NCT07300150
A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors
Alentis Therapeutics
NCT07169734
Reducing Metabolic Dysregulation in Dyads
University of South Carolina
NCT06117241
GENOCARE: A Prospective, Randomized Clinical Trial of Genotype-Guided Dosing Versus Usual Care
Reema A. Patel
NCT05391126
A Study of IBI363 in Subjects with Advanced Solid Malignancies
Innovent Biologics (Suzhou) Co.
NCT06281678
Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators
Cedars-Sinai Medical Center
NCT04722341
Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers
Novartis Pharmaceuticals
NCT06562192
A Study of the Possible Effects of Medication on Young Onset Colorectal Cancer (YOCRC)
Memorial Sloan Kettering Cancer Center
NCT05568420
Telehealth Intervention for Ostomy Self-Management
City of Hope Medical Center
NCT06528990
A First-in-Human Study of SON-DP in Participants With Relapsed/Refractory Intolerant to Standard of Care Therapies for Advanced/Metastatic Solid Tumors
Qurgen
NCT05989724
A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer
Ono Pharmaceutical Co.
NCT06948448
A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
AbbVie
NCT07023289
Study of TU2218 in Combination With KEYTRUDA®(Pembrolizumab) in Patients With Advanced Solid Tumors
TiumBio Co.
NCT05784688
An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia.
NGM Biopharmaceuticals
NCT07033026
A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy
Chimeric Therapeutics
NCT06055439
Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Neonc Technologies
NCT06047379
Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors
MOMA Therapeutics
NCT06974110
A Study of Mental Health Care in People With Cancer
Memorial Sloan Kettering Cancer Center
NCT06037954
A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy
7 Hills Pharma
NCT06362369
Changes in Reproductive and Sexual Health in People With Early Onset Colorectal Cancer
Memorial Sloan Kettering Cancer Center
NCT04812912
A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Colorectal Cancer
Criterium
NCT06992258
Personalized Health Self-Management Training for Colorectal Cancer Survivors
University of Southern California
NCT05984589
Cabozantinib Plus Durvalumab With or Without Tremelimumab in Patients With Gastroesophageal Cancer and Other Gastrointestinal Malignancies
Anwaar Saeed
NCT03539822
FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors
Fate Therapeutics
NCT07216105
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 128 |
| Phase 2 | 68 |
| Phase 3 | 9 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Colorectal Cancer right now
154 recruiting of 382 indexed (40% open).
Phase mix: 12 late (III/IV) vs 196 early (I/II) (early-phase heavy).
Top sponsor: Memorial Sloan Kettering Cancer Center (22 trials), 9 others listed. 50 shown below, recruiting first. #14 of 28,963 conditions by registered trial count.
How open-enrollment share is computed
Open share is recruiting_count divided by trial_count for this condition label in the public registry export. Status can change between pulls; treat the figure as a snapshot of research attention, not treatment availability.
Frequently Asked Questions
How many clinical trials are there for Colorectal Cancer?
PlainTrial tracks 382 US clinical trials for Colorectal Cancer, of which 154 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Colorectal Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.