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Cognitive Decline clinical trials
36 of 62 indexed Cognitive Decline trials are currently recruiting.
62 US clinical trials · 36 currently recruiting
Cognitive Decline is the subject of 62 registered US clinical trials on ClinicalTrials.gov, 36 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is C2N Diagnostics, running 2 of these trials.
The research picture
Cognitive Decline has 62 registered US clinical trials, 36 of them open to new participants right now, about 58% of the total.
- 36
- recruiting participants now
- 58%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 2
- top sponsor: C2N Diagnostics
Active & Recent Trials
62 total, page 1 of 2
Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Communities: The MyCog Trial
Northwestern University
NCT05607732
Preventing Cognitive Decline by Reducing BP Target Trial
University of Texas Southwestern Medical Center
NCT05106036
Enhancing Attention and Wellbeing Using Digital Therapeutics
University of California, San Francisco
NCT06397469
Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease
Neurobehavioral Systems
NCT04800588
Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
Alzheimer's Light
NCT03657745
Older Breast Cancer Patients: Risk for Cognitive Decline
Georgetown University
NCT03451383
Biomarker Exploration in Aging, Cognition and Neurodegeneration
University of California, Irvine
NCT03860857
Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
Indiana University
NCT06627894
Cognitive and Vascular Functioning Following TBI
Walter Reed National Military Medical Center
NCT06034509
Polyphenols and Cognitive Decline
University of California, Los Angeles
NCT06507254
Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient
Stanford University
NCT03839784
Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging
Natalie Denburg
NCT03954899
Exercise Adherence and Cognitive Decline: Phase 2
University of Colorado, Boulder
NCT07127965
A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses
Arizona State University
NCT05877196
δ in Dementia Clinical Trials
The University of Texas Health Science Center at San Antonio
NCT05592678
The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study
California Pacific Medical Center Research Institute
NCT05988385
mPATH for Low-income Older Adults
Johns Hopkins University
NCT05935241
Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia
University of Cincinnati
NCT06933095
Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
Massachusetts General Hospital
NCT06052397
Brain Health Virtual Reality Study
University of California, San Diego
NCT06124339
Study Evaluating the Quality and Effects of Lion's Mane Product on Cognitive Health
M2 Ingredients
NCT06870136
Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance
SF Research Institute
NCT07220694
MIND Foods and Aerobic Training in Black Adults With HTN
Indiana University
NCT06152614
Door-Through-Door Companion Rideshare Technology for Individuals With Alzheimer's Disease and Related Dementias (AD/ADRD)
Onward Health
NCT06850870
A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients
University of Florida
NCT05998031
A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors
University of Washington
NCT06411561
Cognitive Screening Made Easy for PCPs - Administrative Supplement
University of Texas at Austin
NCT06928298
Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline During Chemotherapy in Breast Cancer
UNC Lineberger Comprehensive Cancer Center
NCT06727773
Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study
Ohio State University
NCT06223672
TMS for Cognitive Decline in Aging and Preclinical AD
Massachusetts General Hospital
NCT06956300
Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy
Joseph McCollom
NCT05014399
MindWalk Intervention for Older South Asian Caregivers of People With Cognitive Disabilities (CD)
University of Illinois at Chicago
NCT06002919
Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans
University of Alabama at Birmingham
NCT06217575
Glucose Variability and Cognition in Prediabetes
University of Maryland, Baltimore
NCT04201600
Exercise Adherence and Cognitive Decline
University of Colorado, Boulder
NCT06769022
Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study
Washington University School of Medicine
NCT07000734
Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control in Minimize Cognitive Decline
Tulane University
NCT04797403
Impact of a Novel Brain Longevity Supplement Containing the Postbiotic Urolithin A (Mitopure) on Cognitive Function and Related Health Outcomes
Amazentis
NCT07060898
ACHIEVE Brain Health Follow-Up Study
Johns Hopkins University
NCT05532657
BRINK (BRain In Kidney Disease) Memory Study 2.0
Anne Murray
NCT04975464
Cognitive Screening Made Easy for PCPs - R33 Phase
University of Texas at Austin
NCT06162026
Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
C2N Diagnostics
NCT06025877
Advancing Postmenopausal Preventive Therapy
University of Southern California
NCT04103476
Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers
Akira Sekikawa
NCT05741060
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients
Rush University Medical Center
NCT04337255
High-dose Vitamin D Supplements in Older Adults
University of California, Davis
NCT03613116
Tau Pet Imaging in the Aging Brain Cohort Dedicated to Diversity Study
University of Pennsylvania
NCT05393388
Dopaminergic Dysfunction in Late-Life Depression
Vanderbilt University Medical Center
NCT04469959
Multi-Center Study of Sensory Stimulation to Improve Brain Function
Cognito Therapeutics
NCT03556280
A Clinical Trial to Investigate the Efficacy of a Supplement to Improve and Maintain Cognitive Function and Memory
Scale Media
NCT06523218
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 7 |
| Phase 3 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Cognitive Decline Trial Landscape
62 indexed Cognitive Decline studies · 36 recruiting (58%).
Phase mix: 2 late (III/IV) vs 8 early (I/II).
Top sponsor: C2N Diagnostics (2 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Cognitive Decline?
PlainTrial tracks 62 US clinical trials for Cognitive Decline, of which 36 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Cognitive Decline?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.