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ClinicalTrials.gov 36 recruiting now official registry

Cognitive Decline clinical trials

36 of 62 indexed Cognitive Decline trials are currently recruiting.

62 US clinical trials · 36 currently recruiting

Cognitive Decline is the subject of 62 registered US clinical trials on ClinicalTrials.gov, 36 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is C2N Diagnostics, running 2 of these trials.

The research picture

Cognitive Decline has 62 registered US clinical trials, 36 of them open to new participants right now, about 58% of the total.

36
recruiting participants now
58%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
2
top sponsor: C2N Diagnostics
Phase 11Phase 27Phase 32

Active & Recent Trials

62 total, page 2 of 2

ACTIVE NOT RECRUITING NA 20 participants

The Influence of Tai Chi Practice on Blood Pressure and Brain Health Among Older Adults with Hypertension (ACTION)

University of Connecticut

NCT04384263

COMPLETED 366 participants

Quality Improvement PrecivityAD Clinician Survey (QUIP I)

C2N Diagnostics

NCT05477056

COMPLETED NA 178 participants

Establishing Clinical Utility Evidence for a Novel Alzheimer's Disease Blood-Based Biomarker Assay

Qure Healthcare

NCT07099001

COMPLETED Phase 2 125 participants

Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain Study

Neil M Rofsky, MD, MHA

NCT04080544

COMPLETED 120 participants

Preoperative Cognitive Reserve in Older Surgical Patients: A Feasibility Study

Ohio State University

NCT06245005

COMPLETED NA 69 participants

Noninvasive Brain Stimulation for Mild Cognitive Impairment

Palo Alto Veterans Institute for Research

NCT03331796

COMPLETED NA 67 participants

Long-term Effects of Blueberry Supplementation on Brain Health in Older Adults

Brigham and Women's Hospital

NCT05764824

COMPLETED NA 44 participants

Digital Cognition in Multiple Sclerosis

University of California, San Francisco

NCT03569618

COMPLETED NA 40 participants

Preventing Cognitive Decline

Arizona State University

NCT05446909

COMPLETED NA 25 participants

Movement Intervention for Memory Enhancement

Albert Einstein College of Medicine

NCT03475316

COMPLETED NA 24 participants

Brain Vascular and Neurocognitive Health

The University of Texas at Arlington

NCT06497413

COMPLETED NA 18 participants

Rhythmically Entrained Exercise in Community-Dwelling Older Adults

University of North Carolina, Greensboro

NCT05462977

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Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 7
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cognitive Decline Trial Landscape

62 indexed Cognitive Decline studies · 36 recruiting (58%).

Phase mix: 2 late (III/IV) vs 8 early (I/II).

Top sponsor: C2N Diagnostics (2 trials), 9 others listed. 12 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cognitive Decline?

PlainTrial tracks 62 US clinical trials for Cognitive Decline, of which 36 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cognitive Decline?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.