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NCT06956300 · ClinicalTrials.gov registry record · NA
TMS for Cognitive Decline in Aging and Preclinical AD
A NA study of Cognitive Decline and Healthy Aging, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT06956300 is a NA study of Cognitive Decline and Healthy Aging that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 80 participants, below the 1,148-participant average among 61 other Cognitive Decline trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06956300, a NA study of Cognitive Decline and Healthy Aging, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical Alzheimer's disease. This study will use a form of non-invasive brain stimulation called repetitive Transcranial Magnetic Stimulation (rTMS). rTMS will slightly alter activity in an area of your brain that controls cognition. Changes resulting from this stimulation will be measured with behavioral tests, as well as by taking brain images with Magnetic Resonance Imaging (MRI). Participants will come in for one baseline visit followed by 10 days of daily rTMS study visits (Monday through Friday) and an evaluation visit. Then, there will be a 2-week break. After this break, they will return for another baseline visit, an additional 10 days of rTMS, and a final evaluation visit.
Conditions Studied
Interventions
- DEVICE Active rTMS
- DEVICE Sham rTMS
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2025-04-07 |
| Est. Completion | 2029-08-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06956300
The ClinicalTrials.gov registry entry for NCT06956300 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,148-participant average among 61 other Cognitive Decline trials with a reported enrollment target (93% lower). The listed sponsor is Massachusetts General Hospital, which has 2,032 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Cognitive Decline appearing as the primary indexed condition, and to 2 interventions - of which Active rTMS is the first listed.
NCT06956300 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06956300 about?
NCT06956300 is a clinical study titled "TMS for Cognitive Decline in Aging and Preclinical AD". In this research study we want to learn more about the effects of non-invasive brain stimulation on motivation, memory, and brain-network function in cognitively unimpaired older adults and individuals with preclinical Alzheimer's disease. This study will use a form of non-invasive brain stimulatio...
What is the current status of trial NCT06956300?
This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2025-04-07. Estimated completion is 2029-08-31.
What conditions does trial NCT06956300 study?
This clinical trial studies the following conditions: Cognitive Decline, Healthy Aging, Prodromal Alzheimer's Disease, Preclinical Alzheimer's Disease.
What interventions are being tested in trial NCT06956300?
The interventions under investigation include: Active rTMS (DEVICE), Sham rTMS (DEVICE).
Who is sponsoring clinical trial NCT06956300?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06956300 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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