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NCT06052397 · ClinicalTrials.gov registry record

Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium

A clinical trial of Dementia and Cognitive Decline, sponsored by Massachusetts General Hospital.

Recruiting
Registry status
150
Enrollment target
1
Study location

NCT06052397 is a study of Dementia and Cognitive Decline that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 150 participants, below the 7,722-participant average among 199 other Dementia trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06052397, a study of Dementia and Cognitive Decline, is actively recruiting participants, sponsored by Massachusetts General Hospital.

RECRUITING
Registry status
150 participants
Enrollment target
1
Study location

Study Summary

The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are: 1. To define sleep/circadian biomarkers of delirium (sleep duration, regularity, stability and timing of rhythm) in a prospective observational study. 2. To determine if plasma Alzheimer's disease (AD) pathology/inflammatory burden interacts with or moderates the relationship between a sleep/circadian biomarker and post-operative delirium (POD) risk. 3. To determine whether sleep/circadian regulation interacts with the genetic risk of AD to influence POD/cognitive decline. Participants will be asked to: 1. Donate several blood samples both intraoperatively and postoperatively 2. Complete baseline and postoperative neurocognitive assessments 3. Wear an actigraphy data collection watch for the two weeks prior to their surgery

Conditions Studied

Dementia Cognitive Decline Delirium, Postoperative

Study Locations (1)

Massachusetts

  • Massachusetts General Hospital - Boston

Trial Details

FieldValue
Enrollment Target 150 participants
Start Date 2023-09-12
Est. Completion 2027-09-30

Sponsor

Massachusetts General Hospital

2,032 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06052397

The ClinicalTrials.gov registry entry for NCT06052397 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 150 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 7,722-participant average among 199 other Dementia trials with a reported enrollment target (98% lower). The listed sponsor is Massachusetts General Hospital, which has 2,032 total studies on file at ClinicalTrials.gov.

The record links to 3 conditions, with Dementia appearing as the primary indexed condition, and to 0 interventions.

NCT06052397 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.

Frequently Asked Questions

What is clinical trial NCT06052397 about?

NCT06052397 is a clinical study titled "Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium". The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are: 1. To define sleep/circadian biomarkers of delirium (sleep duration, regularity, stability and timi...

What is the current status of trial NCT06052397?

This trial is currently recruiting. The enrollment target is 150 participants. The study started on 2023-09-12. Estimated completion is 2027-09-30.

What conditions does trial NCT06052397 study?

This clinical trial studies the following conditions: Dementia, Cognitive Decline, Delirium, Postoperative.

Who is sponsoring clinical trial NCT06052397?

This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06052397 being conducted?

This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.