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NCT06052397 · ClinicalTrials.gov registry record
Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
A clinical trial of Dementia and Cognitive Decline, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- 150
- Enrollment target
- 1
- Study location
NCT06052397: Recruiting study of Dementia and Cognitive Decline, sponsored by Massachusetts General Hospital.
NCT06052397 is a study of Dementia and Cognitive Decline that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 150 participants, below the 7,722-participant average among 199 other Dementia trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06052397, a study of Dementia and Cognitive Decline, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- 150 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are: 1. To define sleep/circadian biomarkers of delirium (sleep duration, regularity, stability and timing of rhythm) in a prospective observational study. 2. To determine if plasma Alzheimer's disease (AD) pathology/inflammatory burden interacts with or moderates the relationship between a sleep/circadian biomarker and post-operative delirium (POD) risk. 3. To determine whether sleep/circadian regulation interacts with the genetic risk of AD to influence POD/cognitive decline. Participants will be asked to: 1. Donate several blood samples both intraoperatively and postoperatively 2. Complete baseline and postoperative neurocognitive assessments 3. Wear an actigraphy data collection watch for the two weeks prior to their surgery
Primary Outcome
Outcome will be assessed using the Confusion Assessment Method (CAM)
Conditions Studied
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2023-09-12 |
| Est. Completion | 2027-09-30 |
What NCT06052397 shows while recruiting
NCT06052397 is an observational study that tracks outcomes without assigning an intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 7,722-participant average among 199 other Dementia trials with a reported enrollment target (98% lower).
The record links to 3 conditions, with Dementia appearing as the primary indexed condition, and to 0 interventions.
NCT06052397 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06052397 about?
NCT06052397 is a clinical study titled "Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium". The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are: 1. To define sleep/circadian biomarkers of delirium (sleep duration, regularity, stability and timi...
What is the current status of trial NCT06052397?
This trial is currently recruiting. The enrollment target is 150 participants. The study started on 2023-09-12. Estimated completion is 2027-09-30.
What conditions does trial NCT06052397 study?
This clinical trial studies the following conditions: Dementia, Cognitive Decline, Delirium, Postoperative.
Who is sponsoring clinical trial NCT06052397?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06052397 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06052397's enrollment target sits among peer trials
150 102nd of 199 higher than 97 of 199 other Dementia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Dementia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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