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A Study of JNJ-86974680 in Participants With Advanced Non-small Cell Lung Cancer
NCT06116786 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to determine a safe and tolerable dose(s) of JNJ-86974680 for further research in combination with cetrelimab and radiation therapy.
Conditions Studied
Interventions
- RADIATION Radiation Therapy
- DRUG Cetrelimab
- DRUG JNJ-86974680
Study Locations (15)
Other
- Charite Research Organisation GmbH — Berlin
- Universitaetsklinikum Giessen und Marburg GmbH — Giessen
- Severance Hospital Yonsei University Health System — Seoul
- Samsung Medical Center — Seoul
- Hosp. Univ. Quiron Dexeus — Barcelona
- Hosp Univ Vall D Hebron — Barcelona
- Hosp. Univ. 12 de Octubre — Madrid
- Hosp. Univ. I Politecni La Fe — Valencia
New York
- Roswell Park Comprehensive Cancer Center — Buffalo
- Herbert Irving Comprehensive Cancer Center Columbia University Medical Center — New York
Georgia
- City of Hope — Newnan
New Jersey
- Hackensack University Medical Center — Hackensack
Oregon
- Providence Portland Medical Center — Portland
Pennsylvania
- Thomas Jefferson University — Philadelphia
Virginia
- Next Virginia — Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 126 participants |
| Start Date | 2023-11-27 |
| Est. Completion | 2029-06-07 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06116786
The ClinicalTrials.gov registry entry for NCT06116786 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 126 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Johnson & Johnson Enterprise Innovation, which has 5 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Carcinoma, Non-small-Cell Lung appearing as the primary indexed condition, and to 3 interventions — of which Radiation Therapy is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06116786 reports 15 study locations spanning 7 distinct geographic areas — top geographies include Other, New York, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06116786 about?
NCT06116786 is a clinical study titled "A Study of JNJ-86974680 in Participants With Advanced Non-small Cell Lung Cancer". The purpose of this study is to determine a safe and tolerable dose(s) of JNJ-86974680 for further research in combination with cetrelimab and radiation therapy.
What is the current status of trial NCT06116786?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 126 participants. The study started on 2023-11-27. Estimated completion is 2029-06-07.
What conditions does trial NCT06116786 study?
This clinical trial studies the following conditions: Carcinoma, Non-small-Cell Lung. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06116786?
The interventions under investigation include: Radiation Therapy (RADIATION), Cetrelimab (DRUG), JNJ-86974680 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06116786?
This trial is sponsored by Johnson & Johnson Enterprise Innovation, which has 5 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06116786 being conducted?
This trial has 15 study locations across Georgia, New Jersey, New York, Oregon, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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