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RECRUITING Phase 3

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

NCT06890598 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if olomorasib in combination with durvalumab is more effective than the durvalumab and placebo combination in part B in participants with unresectable KRAS G12C-mutant non-small cell lung cancer. The study may last up to 3 years for each participant.

Interventions

  • DRUG Pembrolizumab
  • DRUG Placebo
  • DRUG Durvalumab
  • DRUG Olomorasib

Study Locations (20)

Florida

  • Boca Raton Regional Hospital — Boca Raton
  • Florida Cancer Specialists - South — Fort Myers
  • University of Florida - Jacksonville — Jacksonville
  • Miami Cancer Institute at Baptist Health, Inc. — Miami
  • Florida Cancer Specialists North — St. Petersburg
  • Comprehensive Hematology Oncology — St. Petersburg
  • Moffitt Cancer Center — Tampa
  • Florida Cancer Specialists East — West Palm Beach

California

  • UCLA Hematology/Oncology - Santa Monica — Los Angeles
  • Profound Research LLC — Oceanside
  • University of California, Irvine (UCI) Health - UC Irvine Medical Center — Orange
  • Stanford Cancer Center — Palo Alto
  • Kaiser Permanente San Diego Mission Road — San Diego
  • BASS Cancer Center — Walnut Creek

Alabama

  • Clearview Cancer Institute — Huntsville
  • Infirmary Cancer Care — Mobile

Arizona

  • The University of Arizona Cancer Center - North Campus — Tucson

Arkansas

  • Highlands Oncology Group — Springdale

Connecticut

  • Hartford Hospital (HH) — Hartford

District of Columbia

  • Sibley Memorial Hospital — Washington D.C.

Trial Details

FieldValue
Enrollment Target 700 participants
Start Date 2025-03-27
Est. Completion 2032-02
Phase Phase 3

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06890598

The ClinicalTrials.gov registry entry for NCT06890598 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 700 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Carcinoma, Non-Small-Cell Lung appearing as the primary indexed condition, and to 4 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06890598 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Florida, California, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06890598 about?

NCT06890598 is a clinical study titled "Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer". The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if olomorasib in combination with durvalumab is more effective tha...

What is the current status of trial NCT06890598?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 700 participants. The study started on 2025-03-27. Estimated completion is 2032-02.

What conditions does trial NCT06890598 study?

This clinical trial studies the following conditions: Carcinoma, Non-Small-Cell Lung. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06890598?

The interventions under investigation include: Pembrolizumab (DRUG), Placebo (DRUG), Durvalumab (DRUG), Olomorasib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06890598?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06890598 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial