Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 2

A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma

NCT05456256 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this clinical trial is to determine clinical advantages for LP-300 in combination with carboplatin and pemetrexed in the never smoker patient population. The primary objectives of this study are to determine progression-free survival (PFS) and overall survival (OS) in the study-defined patient population when LP-300 is co-administered with the standard of care chemotherapy drugs carboplatin and pemetrexed compared to carboplatin and pemetrexed alone. This has been designed as a multicenter, open label, phase II trial with 90 patients to be enrolled in the United States.

Interventions

  • DRUG Carboplatin
  • DRUG Pemetrexed
  • DRUG LP-300

Study Locations (16)

Other

  • Chi Mei Medical Center — Tainan
  • National Cheng Kung University Hospital — Tainan
  • Taipei Veterans General Hospital — Taipei
  • TriService General Hospital-Neihu Main Facility — Taipei
  • National Taiwan University Hospital Hsin-Chu Branch — Taoyuan District

California

  • Precision NextGen Oncology and Research Center — Beverly Hills
  • Los Angeles Cancer Network — Fountain Valley
  • Cancer and Blood Specialists Clinic — Los Alamitos

Pennsylvania

  • Fox Chase Cancer Center — Philadelphia

Texas

  • UT Southwestern Medical Center — Dallas

Virginia

  • Inova Fairfax Hospital — Fairfax

Hokkaido

  • Hokkaido Cancer Center — Sapporo

Kanagawa

  • Kanagawa Cancer Center Hospital — Yokohama

Miyagi

  • Tohoku University Hospital — Sendai

Trial Details

FieldValue
Enrollment Target 90 participants
Start Date 2023-03-01
Est. Completion 2026-06
Phase Phase 2

Sponsor

Lantern Pharma

3 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05456256

The ClinicalTrials.gov registry entry for NCT05456256 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 90 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Lantern Pharma, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Carcinoma, Non-Small-Cell Lung appearing as the primary indexed condition, and to 3 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05456256 reports 16 study locations spanning 10 distinct geographic areas — top geographies include Other, California, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05456256 about?

NCT05456256 is a clinical study titled "A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma". The goal of this clinical trial is to determine clinical advantages for LP-300 in combination with carboplatin and pemetrexed in the never smoker patient population. The primary objectives of this study are to determine progression-free survival (PFS) and overall survival (OS) in the study-defined p...

What is the current status of trial NCT05456256?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 90 participants. The study started on 2023-03-01. Estimated completion is 2026-06.

What conditions does trial NCT05456256 study?

This clinical trial studies the following conditions: Carcinoma, Non-Small-Cell Lung, Adenocarcinoma of Lung. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05456256?

The interventions under investigation include: Carboplatin (DRUG), Pemetrexed (DRUG), LP-300 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05456256?

This trial is sponsored by Lantern Pharma, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05456256 being conducted?

This trial has 16 study locations across California, Pennsylvania, Texas, Virginia, Hokkaido. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial