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Confocal Laser Endomicroscopy VERification
NCT06079970 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this multi-center randomized clinical trial is to evaluate the added value of needle based confocal laser endomicroscopy (nCLE)-imaging to regular diagnostic bronchoscopic peripheral lung lesion analysis on the diagnostic yield in patients with peripheral pulmonary nodules suspect for malignancy. The main question\[s\] it aims to answer are: To determine if the addition of nCLE-imaging to conventional diagnostic bronchoscopic peripheral lung lesion analysis results in an improved diagnostic yield (defined as the proportion of patients in whom the bronchoscopic procedure results in a definitive diagnosis out of the total number of patients that have received the diagnostic bronchoscopic procedure). Participants will undergo diagnostic bronchoscopy either with or without the addition of nCLE imaging before each TBNA. Based on the feedback of the CLE images on (in)correct placement of the needle, the needle might be repositioned before sampling. Comparison between the diagnostic yield of these groups will be done including subgroup analysis.
Conditions Studied
Interventions
- DEVICE Neelde Based Confocal Laser Endomicroscopy
- PROCEDURE Conventional diagnostic bronchoscopy
Study Locations (7)
Other
- Vienna General Hospital — Vienna
- General University Hospital Prague — Prague
- Sotiria Hospital — Athens
- Morgagni Pierantoni Hospital — Forlì
- Amsterdam University Medical Centers — Amsterdam
- University Hospital basel — Basel
New York
- Montefiore Medical Center — New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 208 participants |
| Start Date | 2023-10-18 |
| Est. Completion | 2025-10-18 |
| Phase | NA |
Sponsor
Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)1 total trials
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06079970
The ClinicalTrials.gov registry entry for NCT06079970 describes a study currently listed as recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 208 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC), which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 4 conditions, with Lung Cancer appearing as the primary indexed condition, and to 2 interventions — of which Neelde Based Confocal Laser Endomicroscopy is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06079970 reports 7 study locations spanning 2 distinct geographic areas — top geographies include Other, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06079970 about?
NCT06079970 is a clinical study titled "Confocal Laser Endomicroscopy VERification". The goal of this multi-center randomized clinical trial is to evaluate the added value of needle based confocal laser endomicroscopy (nCLE)-imaging to regular diagnostic bronchoscopic peripheral lung lesion analysis on the diagnostic yield in patients with peripheral pulmonary nodules suspect for ma...
What is the current status of trial NCT06079970?
This trial is currently recruiting. It is a NA study. The enrollment target is 208 participants. The study started on 2023-10-18. Estimated completion is 2025-10-18.
What conditions does trial NCT06079970 study?
This clinical trial studies the following conditions: Lung Cancer, Carcinoma, Non-Small-Cell Lung, Lung Neoplasm Malignant, Neoplasm of Lung. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06079970?
The interventions under investigation include: Neelde Based Confocal Laser Endomicroscopy (DEVICE), Conventional diagnostic bronchoscopy (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06079970?
This trial is sponsored by Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC), which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06079970 being conducted?
This trial has 7 study locations across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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