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RECRUITING Phase 1

Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C)

NCT04956640 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to find out whether the study drug, LY3537982, is safe and effective in cancer patients who have a specific genetic mutation (KRAS G12C). Patients must have already received or were not able to tolerate the standard of care, except for specific groups who have not had cancer treatment. The study will last up to approximately 4 years.

Interventions

  • DRUG Pembrolizumab
  • DRUG Cisplatin
  • DRUG Pemetrexed
  • DRUG Cetuximab
  • DRUG LY3537982

Study Locations (20)

New York

  • NYU Langone Health- Long Island — Mineola
  • NYU Langone — New York
  • Memorial Sloan Kettering Cancer Center — New York

North Carolina

  • The University of North Carolina at Chapel Hill — Chapel Hill
  • Novant Health Cancer Institute - Elizabeth — Charlotte
  • Novant Health Cancer Institute - Forsyth — Winston-Salem

California

  • USC Norris Cancer Hospital — Los Angeles
  • Chao Family Comprehensive Cancer Ctr. — Orange

Florida

  • AdventHealth Orlando — Orlando
  • Florida Cancer Specialists — Sarasota

Indiana

  • Indiana Univ Melvin & Bren Simon Cancer Center — Indianapolis
  • Community Health Network — Indianapolis

Pennsylvania

  • Fox Chase Cancer Center — Philadelphia
  • UPMC Hillman Cancer Center — Pittsburgh

Alabama

  • University of Alabama at Birmingham — Birmingham

Connecticut

  • Yale-New Haven Hospital — New Haven

Trial Details

FieldValue
Enrollment Target 540 participants
Start Date 2021-07-19
Est. Completion 2027-04
Phase Phase 1

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04956640

The ClinicalTrials.gov registry entry for NCT04956640 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 540 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 6 conditions, with Carcinoma, Non-Small-Cell Lung appearing as the primary indexed condition, and to 5 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04956640 reports 20 study locations spanning 12 distinct geographic areas — top geographies include New York, North Carolina, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04956640 about?

NCT04956640 is a clinical study titled "Study of LY3537982 in Cancer Patients With a Specific Genetic Mutation (KRAS G12C)". The purpose of this study is to find out whether the study drug, LY3537982, is safe and effective in cancer patients who have a specific genetic mutation (KRAS G12C). Patients must have already received or were not able to tolerate the standard of care, except for specific groups who have not had ca...

What is the current status of trial NCT04956640?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 540 participants. The study started on 2021-07-19. Estimated completion is 2027-04.

What conditions does trial NCT04956640 study?

This clinical trial studies the following conditions: Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Endometrial Neoplasms. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04956640?

The interventions under investigation include: Pembrolizumab (DRUG), Cisplatin (DRUG), Pemetrexed (DRUG), Cetuximab (DRUG), LY3537982 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04956640?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04956640 being conducted?

This trial has 20 study locations across Alabama, California, Connecticut, Florida, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial