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NCT06623422 · ClinicalTrials.gov registry record · Phase 3
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
A Phase 3 study of Carcinoma, Non-Small Cell Lung, sponsored by Merck Sharp & Dohme.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 680
- Enrollment target
- 20
- Study locations
NCT06623422: Recruiting Phase 3 study of Carcinoma, Non-Small Cell Lung, sponsored by Merck Sharp & Dohme.
NCT06623422 is a Phase 3 study of Carcinoma, Non-Small Cell Lung that is actively recruiting participants, run by Merck Sharp & Dohme. The registered enrollment target is 680 participants, above the 319-participant average among 130 other Carcinoma, Non-Small Cell Lung trials with a reported enrollment target (113% higher). The trial reports 20 study locations across 10 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06623422, a Phase 3 study of Carcinoma, Non-Small Cell Lung, is actively recruiting participants, sponsored by Merck Sharp & Dohme.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 680 participants
- Enrollment target
- 20
- Study locations
Study Summary
The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer from coming back in people with non-small cell lung cancer (NSCLC) whose tumors did not respond completely to treatment before surgery (neoadjuvant treatment).
Primary Outcome
DFS is defined as the time from randomization to any recurrence (local, locoregional, regional or distant), occurrence of new primary NSCLC, as assessed by the investigator, or death due to any cause, whichever occurs first.
Conditions Studied
Interventions
- BIOLOGICAL Pembrolizumab
- DRUG Carboplatin
- DRUG Cisplatin
- DRUG Pemetrexed
- DRUG Gemcitabine
Study Locations (20)
California
- Providence St. Jude Medical Center ( Site 0106) - Fullerton
- VA Long Beach Healthcare System ( Site 0199) - Long Beach
- USC Norris Comprehensive Cancer Center ( Site 0205) - Los Angeles
- UCSF Medical Center at Mission Bay ( Site 0178) - San Francisco
Colorado
- University of Colorado Anschutz Medical Campus ( Site 0151) - Aurora
- UCHealth Memorial Hospital Central ( Site 0125) - Colorado Springs
- Banner MD Anderson Cancer Center at North Colorado Medical Center ( Site 0207) - Greeley
- Centura Health - St. Anthony North Health Campus ( Site 0189) - Westminster
Arizona
- Banner MD Anderson Cancer Center ( Site 0181) - Gilbert
- The University of Arizona Cancer Center - North Campus ( Site 0163) - Tucson
Connecticut
- Yale University School of Medicine ( Site 0201) - New Haven
- Eastern CT Hematology & Oncology Associates ( Site 0202) - Norwich
Florida
- The Oncology Institute of Hope and Innovation - Fort Lauderdale ( Site 0156) - Fort Lauderdale
- Miami Cancer Institute at Baptist Health, Inc. ( Site 0214) - Miami
Massachusetts
- Massachusetts General Hospital ( Site 0136) - Boston
- Dana Farber Cancer Hospital ( Site 0155) - Boston
Idaho
- Beacon Cancer Care ( Site 0127) - Post Falls
Illinois
- The University of Chicago Medical Center ( Site 0118) - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 680 participants |
| Start Date | 2024-10-21 |
| Est. Completion | 2038-01-26 |
| Phase | Phase 3 |
What NCT06623422 shows while recruiting
NCT06623422 is an interventional study that assigns participants to a tested intervention. The registered 680 participants enrollment target is mid-sized for trials with a published cap, above the 319-participant average among 130 other Carcinoma, Non-Small Cell Lung trials with a reported enrollment target (113% higher).
The record links to 1 condition, with Carcinoma, Non-Small Cell Lung appearing as the primary indexed condition, and to 5 interventions - of which Pembrolizumab is the first listed.
NCT06623422 names 20 study sites across 10 states, led by California, Colorado, Arizona.
Frequently Asked Questions
What is clinical trial NCT06623422 about?
NCT06623422 is a clinical study titled "A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)". The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer fr...
What is the current status of trial NCT06623422?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 680 participants. The study started on 2024-10-21. Estimated completion is 2038-01-26.
What conditions does trial NCT06623422 study?
This clinical trial studies the following conditions: Carcinoma, Non-Small Cell Lung.
What interventions are being tested in trial NCT06623422?
The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Carboplatin (DRUG), Cisplatin (DRUG), Pemetrexed (DRUG), Gemcitabine (DRUG).
Who is sponsoring clinical trial NCT06623422?
This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06623422 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Carcinoma, Non-Small Cell Lung
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06623422's enrollment target sits among peer trials
680 21st of 130 higher than 110 of 130 other Carcinoma, Non-Small Cell Lung trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Carcinoma, Non-Small Cell Lung trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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