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RECRUITING Phase 3

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

NCT06623422 · View on ClinicalTrials.gov ↗

Study Summary

The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer from coming back in people with non-small cell lung cancer (NSCLC) whose tumors did not respond completely to treatment before surgery (neoadjuvant treatment).

Interventions

  • BIOLOGICAL Pembrolizumab
  • DRUG Carboplatin
  • DRUG Cisplatin
  • DRUG Pemetrexed
  • DRUG Gemcitabine

Study Locations (20)

California

  • Providence St. Jude Medical Center ( Site 0106) — Fullerton
  • VA Long Beach Healthcare System ( Site 0199) — Long Beach
  • USC Norris Comprehensive Cancer Center ( Site 0205) — Los Angeles
  • UCSF Medical Center at Mission Bay ( Site 0178) — San Francisco

Colorado

  • University of Colorado Anschutz Medical Campus ( Site 0151) — Aurora
  • UCHealth Memorial Hospital Central ( Site 0125) — Colorado Springs
  • Banner MD Anderson Cancer Center at North Colorado Medical Center ( Site 0207) — Greeley
  • Centura Health - St. Anthony North Health Campus ( Site 0189) — Westminster

Arizona

  • Banner MD Anderson Cancer Center ( Site 0181) — Gilbert
  • The University of Arizona Cancer Center - North Campus ( Site 0163) — Tucson

Connecticut

  • Yale University School of Medicine ( Site 0201) — New Haven
  • Eastern CT Hematology & Oncology Associates ( Site 0202) — Norwich

Florida

  • The Oncology Institute of Hope and Innovation - Fort Lauderdale ( Site 0156) — Fort Lauderdale
  • Miami Cancer Institute at Baptist Health, Inc. ( Site 0214) — Miami

Massachusetts

  • Massachusetts General Hospital ( Site 0136) — Boston
  • Dana Farber Cancer Hospital ( Site 0155) — Boston

Idaho

  • Beacon Cancer Care ( Site 0127) — Post Falls

Illinois

  • The University of Chicago Medical Center ( Site 0118) — Chicago

Trial Details

FieldValue
Enrollment Target 680 participants
Start Date 2024-10-21
Est. Completion 2038-01-26
Phase Phase 3

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06623422

The ClinicalTrials.gov registry entry for NCT06623422 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 680 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Carcinoma, Non-Small-Cell Lung appearing as the primary indexed condition, and to 5 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06623422 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, Colorado, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06623422 about?

NCT06623422 is a clinical study titled "A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)". The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer fr...

What is the current status of trial NCT06623422?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 680 participants. The study started on 2024-10-21. Estimated completion is 2038-01-26.

What conditions does trial NCT06623422 study?

This clinical trial studies the following conditions: Carcinoma, Non-Small-Cell Lung. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06623422?

The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Carboplatin (DRUG), Cisplatin (DRUG), Pemetrexed (DRUG), Gemcitabine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06623422?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06623422 being conducted?

This trial has 20 study locations across Arizona, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial