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RECRUITING Phase 2

Immune Profile Selection By Fraction of ctDNA in Patients With Advanced NSCLC Treated With Immunotherapy

NCT05715229 · View on ClinicalTrials.gov ↗

Study Summary

This clinical trial plans to assess to what extent the on-treatment circulating tumor DNA (ctDNA) can predict the subset of patients with NSCLC who will respond to immunotherapy treatment only and which patients will need both immunotherapy and chemotherapy modalities for their treatment regimen.

Interventions

  • DRUG Carboplatin
  • DRUG Pemetrexed
  • DRUG Nivolumab
  • DRUG Ipilimumab
  • DRUG Paclitaxel

Study Locations (3)

New Jersey

  • John Theurer Cancer Center, Hackensack Meridian Health — Hackensack
  • Jersey Shore University Medical Center — Neptune City

District of Columbia

  • Lombardi Comprehensive Cancer Center, Georgetown University — Washington D.C.

Trial Details

FieldValue
Enrollment Target 108 participants
Start Date 2023-09-29
Est. Completion 2027-04-28
Phase Phase 2

Sponsor

Hackensack Meridian Health

57 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05715229

The ClinicalTrials.gov registry entry for NCT05715229 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 108 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hackensack Meridian Health, which has 57 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Carcinoma, Non-Small-Cell Lung appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05715229 reports 3 study locations spanning 2 distinct geographic areas — top geographies include New Jersey, District of Columbia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05715229 about?

NCT05715229 is a clinical study titled "Immune Profile Selection By Fraction of ctDNA in Patients With Advanced NSCLC Treated With Immunotherapy". This clinical trial plans to assess to what extent the on-treatment circulating tumor DNA (ctDNA) can predict the subset of patients with NSCLC who will respond to immunotherapy treatment only and which patients will need both immunotherapy and chemotherapy modalities for their treatment regimen.

What is the current status of trial NCT05715229?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 108 participants. The study started on 2023-09-29. Estimated completion is 2027-04-28.

What conditions does trial NCT05715229 study?

This clinical trial studies the following conditions: Carcinoma, Non-Small-Cell Lung. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05715229?

The interventions under investigation include: Carboplatin (DRUG), Pemetrexed (DRUG), Nivolumab (DRUG), Ipilimumab (DRUG), Paclitaxel (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05715229?

This trial is sponsored by Hackensack Meridian Health, which has 57 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05715229 being conducted?

This trial has 3 study locations across District of Columbia, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial