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NCT06447662 · ClinicalTrials.gov registry record · Phase 1

A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

A Phase 1 study of Carcinoma, Non-Small Cell Lung and Colorectal Neoplasms, sponsored by Pfizer.

Recruiting
Registry status
Phase 1
Development phase
330
Enrollment target
20
Study locations

NCT06447662 is a Phase 1 study of Carcinoma, Non-Small Cell Lung and Colorectal Neoplasms that is actively recruiting participants, run by Pfizer. The registered enrollment target is 330 participants, roughly in line with the 321-participant average among 130 other Carcinoma, Non-Small Cell Lung trials with a reported enrollment target. The trial reports 20 study locations across 7 states.

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The verdict

NCT06447662, a Phase 1 study of Carcinoma, Non-Small Cell Lung and Colorectal Neoplasms, is actively recruiting participants, sponsored by Pfizer.

RECRUITING
Registry status
Phase 1
Development phase
330 participants
Enrollment target
20
Study locations

Study Summary

The purpose of this study is to learn about the safety and effects of the study medicine alone or when given together with other anti-cancer therapies. This study also aims to find the best dose. This study is seeking participants who have solid tumors (a mass of abnormal cells that forms a lump or growth in the body) that: * are advanced (cancer that doesn't disappear or stay away with treatment) and * have a KRAS gene mutation (a change in the DNA of the KRAS gene that can cause cells to grow in very high numbers). This includes (but limited to) the following cancer types: Non-Small Cell Lung Cancer (NSCLC): It's a type of lung cancer where the cells grow slowly but often spread to other parts of the body. Colorectal Cancer (CRC): This is a disease where cells in the colon (a part of large intestine) or rectum grow out of control. Pancreatic ductal adenocarcinoma (PDAC): This is a cancer that starts in the ducts of the pancreas but can spread quickly to other parts of the body. Pancreas is a long, flat gland that lies in the abdomen behind the stomach. Pancreas creates enzymes that help with digestion. It also makes hormones that can help control your blood sugar levels. All participants in this study will take the study medication (PF-07934040) as pill by mouth twice a day repeating for 21-day or 28-day cycles. Depending on which part of the study participants are enrolled into they will receive the study medication (PF-07934040 alone or in combination with other anti-cancer medications). These anti-cancer medications will be given in the study clinic by intravenous (IV) that is directly injected into the veins at various times (depending on the treatment) during the 21-day or 28-day cycle. Participants can continue to take the study medication (PF-07934040) and the combination anti-cancer therapy until their cancer is no longer responding. The study will look at the experiences of people receiving the study medicines. This will help see if the study me

Conditions Studied

Carcinoma, Non-Small Cell Lung Colorectal Neoplasms Carcinoma, Pancreatic Ductal

Interventions

  • COMBINATION_PRODUCT Gemcitabine
  • DRUG PF-07934040
  • COMBINATION_PRODUCT Nab-paclitaxel
  • COMBINATION_PRODUCT Cetuximab
  • COMBINATION_PRODUCT Fluorouracil

Study Locations (20)

Missouri

  • Siteman Cancer Center - St Peters - City of Saint Peters
  • Siteman Cancer Center - West County - Creve Coeur
  • Siteman Cancer Center - North County - Florissant
  • Siteman Cancer Center - St Louis
  • Barnes-Jewish Hospital - St Louis
  • Washington University School of Medicine - St Louis
  • Siteman Cancer Center - South County - St Louis

Colorado

  • University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP) - Aurora
  • University of Colorado Hospital - Anschutz Outpatient Pavilion - Aurora
  • University of Colorado Hospital- Anschutz Cancer Pavilion (ACP) - Aurora
  • University of Colorado Hospital - Aurora

Arkansas

  • Highlands Oncology Group, PA - Fayetteville
  • Highlands Oncology Group, PA - Rogers
  • Highlands Oncology Group - Springdale

California

  • City of Hope (City of Hope National Medical Center, City of Hope Medical Center) - Duarte
  • City of Hope Investigational Drug Service (IDS) - Duarte

North Carolina

  • Duke University Medical Center, lnvestigational Chemotherapy Service - Durham
  • Duke University Medical Center - Durham

District of Columbia

  • Sibley Memorial Hospital - Washington D.C.

Michigan

  • START Midwest - Grand Rapids

Trial Details

FieldValue
Enrollment Target 330 participants
Start Date 2024-06-27
Est. Completion 2028-09-09
Phase Phase 1

Sponsor

Pfizer

1,845 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06447662

The ClinicalTrials.gov registry entry for NCT06447662 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 330 participants, a figure that helps gauge the scale of data the investigators plan to collect, roughly in line with the 321-participant average among 130 other Carcinoma, Non-Small Cell Lung trials with a reported enrollment target. The listed sponsor is Pfizer, which has 1,845 total studies on file at ClinicalTrials.gov.

The record links to 3 conditions, with Carcinoma, Non-Small Cell Lung appearing as the primary indexed condition, and to 5 interventions - of which Gemcitabine is the first listed.

NCT06447662 reports 20 study locations spanning 7 distinct geographic areas - top geographies include Missouri, Colorado, Arkansas.

Frequently Asked Questions

What is clinical trial NCT06447662 about?

NCT06447662 is a clinical study titled "A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.". The purpose of this study is to learn about the safety and effects of the study medicine alone or when given together with other anti-cancer therapies. This study also aims to find the best dose. This study is seeking participants who have solid tumors (a mass of abnormal cells that forms a lump or...

What is the current status of trial NCT06447662?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 330 participants. The study started on 2024-06-27. Estimated completion is 2028-09-09.

What conditions does trial NCT06447662 study?

This clinical trial studies the following conditions: Carcinoma, Non-Small Cell Lung, Colorectal Neoplasms, Carcinoma, Pancreatic Ductal.

What interventions are being tested in trial NCT06447662?

The interventions under investigation include: Gemcitabine (COMBINATION_PRODUCT), PF-07934040 (DRUG), Nab-paclitaxel (COMBINATION_PRODUCT), Cetuximab (COMBINATION_PRODUCT), Fluorouracil (COMBINATION_PRODUCT).

Who is sponsoring clinical trial NCT06447662?

This trial is sponsored by Pfizer, which has 1,845 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06447662 being conducted?

This trial has 20 study locations across Arkansas, California, Colorado, District of Columbia, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.