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ClinicalTrials.gov 43 recruiting now official registry

Carcinoma, Non-Small Cell Lung clinical trials

43 of 133 indexed Carcinoma, Non-Small Cell Lung trials are currently recruiting.

133 US clinical trials · 43 currently recruiting

Carcinoma, Non-Small Cell Lung is the subject of 133 registered US clinical trials on ClinicalTrials.gov, 43 of them currently open to new participants. 27 are in Phase 3-4 (later-stage) and 92 in Phase 1-2 (earlier-stage). The most active sponsor is Pfizer, running 14 of these trials.

The research picture

Carcinoma, Non-Small Cell Lung has 133 registered US clinical trials, 43 of them open to new participants right now, about 32% of the total.

43
recruiting participants now
32%
of trials open to enrollment
27
in Phase 3–4 (later-stage)
14
top sponsor: Pfizer
Phase 158Phase 234Phase 327

Active & Recent Trials

133 total, page 2 of 3

ACTIVE NOT RECRUITING Phase 3 614 participants

Study of Pembrolizumab (MK-3475) Monotherapy Versus Sacituzumab Govitecan in Combination With Pembrolizumab for Participants With Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-3475-D46)

Merck Sharp & Dohme

NCT05609968

ACTIVE NOT RECRUITING Phase 3 611 participants

Study of Pembrolizumab/Vibostolimab (MK-7684A) in Combination With Concurrent Chemoradiotherapy Followed by Pembrolizumab/Vibostolimab Versus Concurrent Chemoradiotherapy Followed by Durvalumab in Participants With Stage III Non-small Cell Lung Cancer (MK-7684A-006)

Merck Sharp & Dohme

NCT05298423

ACTIVE NOT RECRUITING Phase 3 461 participants

A Study of Neoadjuvant Chemotherapy Plus Nivolumab Versus Neoadjuvant Chemotherapy Plus Placebo, Followed by Surgical Removal and Adjuvant Treatment With Nivolumab or Placebo for Participants With Surgically Removable Early Stage Non-small Cell Lung Cancer

Bristol-Myers Squibb

NCT04025879

ACTIVE NOT RECRUITING Phase 2 352 participants

Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT03485209

ACTIVE NOT RECRUITING Phase 1 344 participants

Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

Novartis Pharmaceuticals

NCT04699188

ACTIVE NOT RECRUITING Phase 1 334 participants

A Study of TAK-788 in Adults With Non-Small Cell Lung Cancer

Takeda

NCT02716116

ACTIVE NOT RECRUITING Phase 3 308 participants

A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions

Janssen Research & Development

NCT04538664

ACTIVE NOT RECRUITING Phase 3 296 participants

A Study Of Lorlatinib Versus Crizotinib In First Line Treatment Of Patients With ALK-Positive NSCLC

Pfizer

NCT03052608

ACTIVE NOT RECRUITING Phase 3 257 participants

A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive Non-Small Cell Lung Cancer

Hoffmann-La Roche

NCT03456076

ACTIVE NOT RECRUITING Phase 2 217 participants

Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations

Seagen, a wholly owned subsidiary of Pfizer

NCT04579380

ACTIVE NOT RECRUITING Phase 3 190 participants

A Study of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3)

Bristol-Myers Squibb

NCT06140836

ACTIVE NOT RECRUITING Phase 3 152 participants

A Study of Selpercatinib After Surgery or Radiation in Participants With Non-Small Cell Lung Cancer (NSCLC)

Eli Lilly and Company

NCT04819100

ACTIVE NOT RECRUITING Phase 1 136 participants

A Study to Assess the Safety and Efficacy of AZD7789 in Participants With Advanced or Metastatic Solid Cancer

AstraZeneca

NCT04931654

ACTIVE NOT RECRUITING Phase 1 126 participants

A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers

Novartis Pharmaceuticals

NCT05544929

ACTIVE NOT RECRUITING Phase 2 120 participants

A Study of Disitamab Vedotin in Previously Treated Solid Tumors That Express HER2

Seagen, a wholly owned subsidiary of Pfizer

NCT06003231

ACTIVE NOT RECRUITING Phase 1 98 participants

Study of Safety and Efficacy of DKY709 Alone or in Combination With PDR001 in Patients With Advanced Solid Tumors.

Novartis Pharmaceuticals

NCT03891953

ACTIVE NOT RECRUITING Phase 2 83 participants

NT-I7 in Combination With Atezolizumab in Previously Untreated, PD-L1-expressing, Locally Advanced or Metastatic NSCLC

NeoImmuneTech

NCT04984811

ACTIVE NOT RECRUITING Phase 1 74 participants

Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

Novartis Pharmaceuticals

NCT05358249

ACTIVE NOT RECRUITING Phase 1 71 participants

A Study of Combination Therapy With Amivantamab and Cetrelimab in Participants With Metastatic Non-small Cell Lung Cancer

Janssen Research & Development

NCT05908734

ACTIVE NOT RECRUITING Phase 1 70 participants

A Study of LOXO-260 in Cancer Patients With a Change in a Particular Gene (RET) That Has Not Responded to Treatment

Eli Lilly and Company

NCT05241834

ACTIVE NOT RECRUITING Phase 2 68 participants

Premedication to Reduce Amivantamab Associated Infusion Related Reactions

Janssen Research & Development

NCT05663866

ACTIVE NOT RECRUITING Phase 1 65 participants

A Study of PF-08046052/SGN-EGFRd2 in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT05983133

ACTIVE NOT RECRUITING Phase 1 57 participants

A Study of Amivantamab and Capmatinib Combination Therapy in Unresectable Metastatic Non-small Cell Lung Cancer

Janssen Research & Development

NCT05488314

ACTIVE NOT RECRUITING Phase 2 43 participants

A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC

Joseph J. Cullen, MD, FACS

NCT02905591

ACTIVE NOT RECRUITING Phase 1 43 participants

Oleclumab (MEDI9447) Epidermal Growth Factor Receptor Mutant (EGFRm) Non-small Cell Lung Cancer (NSCLC) Novel Combination Study

MedImmune

NCT03381274

ACTIVE NOT RECRUITING Phase 1 30 participants

A Study to Learn About the Study Medicine PF-07985045 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Change in a Gene.

Pfizer

NCT06704724

ACTIVE NOT RECRUITING Phase 1 19 participants

A Study of SGN-MesoC2 in Advanced Solid Tumors

Seagen, a wholly owned subsidiary of Pfizer

NCT06466187

ACTIVE NOT RECRUITING Phase 1 18 participants

Astra Zeneca (Immuno Stereotactic Ablative Body Radiotherapy) ISABR Study: Randomized Phase I/II Study of Stereotactic Body Radiotherapy

Jonsson Comprehensive Cancer Center

NCT03148327

ACTIVE NOT RECRUITING Phase 1 16 participants

MK-3475 and Gemcitabine in Non-Small Cell Lung Cancer (NSCLC)

Providence Health & Services

NCT02422381

ACTIVE NOT RECRUITING Phase 1 12 participants

A Study of Combination Therapy With Amivantamab and Docetaxel in Participants With Metastatic Non-small Cell Lung Cancer

Janssen Research & Development

NCT06532032

ACTIVE NOT RECRUITING Phase 1 9 participants

A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic Malignancies

Pfizer

NCT06974734

ACTIVE NOT RECRUITING Phase 1 6 participants

Safety & Efficacy of Consolidative Hypofractionated Radiation Therapy for Boosting Residual Lung Cancer With Durvalumab

University of Nebraska

NCT04748419

ACTIVE NOT RECRUITING 5 participants

Metabolic Response to Food in Lung Cancer

Pennington Biomedical Research Center

NCT05937074

COMPLETED Phase 3 960 participants

A Study In Patients With Non-Small Cell Lung Cancer To Test If Erlotinib Plus SU011248 Is Better Than Erlotinib Alone

Pfizer

NCT00457392

COMPLETED Phase 3 731 participants

Evaluation of FKB238 and Avastin in Patients With Advanced/Recurrent Non-squamous Non-small Cell Lung Cancer

Centus Biotherapeutics Limited

NCT02810457

COMPLETED Phase 3 718 participants

Lume Lung 2 : BIBF 1120 Plus Pemetrexed Compared to Placebo Plus Pemetrexed in 2nd Line Nonsquamous NSCLC

Boehringer Ingelheim

NCT00806819

COMPLETED Phase 3 568 participants

Study of Pembrolizumab Given With Ipilimumab or Placebo in Participants With Untreated Metastatic Non-Small Cell Lung Cancer (NSCLC) (MK-3475-598/KEYNOTE-598)

Merck Sharp & Dohme

NCT03302234

COMPLETED Phase 3 550 participants

Study of Neurologic Progression With Motexafin Gadolinium and Radiation Therapy (SMART)

Pharmacyclics

NCT00054795

COMPLETED 501 participants

A Study of Preferences for the First-Line Treatment of Advanced/Metastatic Non-Small Cell Lung Cancer

Bristol-Myers Squibb

NCT05250817

COMPLETED Phase 2 373 participants

Study of Oral cMET Inhibitor INC280 in Patients With EGFR Wild-type (wt), Advanced Non-small Cell Lung Cancer (NSCLC) (Geometry Mono-1)

Novartis Pharmaceuticals

NCT02414139

COMPLETED 228 participants

Real World Data on Gi(l)Otrif® Dose Adjustment

Boehringer Ingelheim

NCT02751879

COMPLETED Phase 1 190 participants

A Study Of PF-05082566 As A Single Agent And In Combination With Rituximab

Pfizer

NCT01307267

COMPLETED Phase 1 180 participants

Evaluation Of The Efficacy Of The Combination Of Axitinib With Pemetrexed And Cisplatin In The Treatment Of Non-Squamous Non-Small Cell Lung Cancer

Pfizer

NCT00768755

COMPLETED Phase 2 160 participants

This Study is to Compare the Efficacy of ZD6474 and ZD1839 in Subjects With NSCLC.

Genzyme, a Sanofi Company

NCT00059722

COMPLETED Phase 1 150 participants

A Phase 1 Study in Participants With Advanced Cancer

Eli Lilly and Company

NCT01115790

COMPLETED Phase 1 141 participants

Study to Evaluate Erlotinib With or Without SNDX-275 (Entinostat) in the Treatment of Patients With Advanced NSCLC

Syndax Pharmaceuticals

NCT00602030

COMPLETED Phase 1 120 participants

An Exploratory Pharmacogenomic Study of Monotherapy Erbitux in Subjects With Metastatic Non Small Cell Lung Carcinoma

Eli Lilly and Company

NCT00207116

COMPLETED Phase 2 111 participants

Study Of SU011248 In Patients With Metastatic Non-Small Cell Lung Cancer

Pfizer

NCT00092001

COMPLETED Phase 3 89 participants

Phase III Study to Determine the Efficacy of Durvalumab in Combination With Chemotherapy in Completely Resected Stage II-III Non-small Cell Lung Cancer (NSCLC)

AstraZeneca

NCT04385368

COMPLETED Phase 1 80 participants

Study of DN101 and Taxotere in Patients With Advanced Non-Small Cell Lung Cancer

Novacea

NCT00066885

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Phase Distribution

PhaseTrial count
Phase 1 58
Phase 2 34
Phase 3 27

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Carcinoma, Non-Small Cell Lung Trial Landscape

133 indexed Carcinoma, Non-Small Cell Lung studies · 43 recruiting (32%).

Phase mix: 27 late (III/IV) vs 92 early (I/II).

Top sponsor: Pfizer (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Carcinoma, Non-Small Cell Lung?

PlainTrial tracks 133 US clinical trials for Carcinoma, Non-Small Cell Lung, of which 43 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Carcinoma, Non-Small Cell Lung?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.