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ClinicalTrials.gov 41 recruiting now official registry

Brain Metastases clinical trials

41 of 68 indexed Brain Metastases trials are currently recruiting.

68 US clinical trials · 41 currently recruiting

Brain Metastases is the subject of 68 registered US clinical trials on ClinicalTrials.gov, 41 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 48 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 7 of these trials.

The research picture

Brain Metastases has 68 registered US clinical trials, 41 of them open to new participants right now, about 60% of the total.

41
recruiting participants now
60%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
7
top sponsor: M.D. Anderson Cancer Center
Phase 122Phase 226Phase 32Phase 41

Active & Recent Trials

68 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 2 21 participants

Study Assessing QBS72S For Treating Brain Metastases

Stanford University

NCT05305365

ACTIVE NOT RECRUITING Phase 1 21 participants

GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases

Memorial Sloan Kettering Cancer Center

NCT04192981

ACTIVE NOT RECRUITING Early Phase 1 11 participants

A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors

Memorial Sloan Kettering Cancer Center

NCT06209567

ACTIVE NOT RECRUITING Phase 1 2 participants

A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain

Memorial Sloan Kettering Cancer Center

NCT06132945

COMPLETED Phase 1 84 participants

An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma.

BBB-Therapeutics B.V.

NCT01386580

COMPLETED Phase 2 72 participants

ANG1005 in Breast Cancer Patients With Recurrent Brain Metastases

Angiochem

NCT02048059

COMPLETED Phase 2 65 participants

MK-3475 in Melanoma and NSCLC Patients With Brain Metastases

Yale University

NCT02085070

COMPLETED 52 participants

MRI Study of Changes in Blood-Brain/Tumor-Barrier Permeability in Patients With Brain Metastases During and After Radiotherapy

University of Michigan Rogel Cancer Center

NCT02031237

COMPLETED Phase 2 50 participants

GliaSite 1-3 Mets Study

Hologic

NCT00589212

COMPLETED Phase 2 36 participants

Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases

Kadmon Corporation

NCT02616393

COMPLETED Phase 1 29 participants

Dose-Escalation Study of RRx-001 in Combination With Whole Brain Radiation in Subjects With Brain Metastases

EpicentRx

NCT02215512

COMPLETED Phase 2 20 participants

DM-CHOC-PEN for Brain Tumors in AYA Subjects

DEKK-TEC

NCT03668847

COMPLETED Phase 1 17 participants

Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT00838929

COMPLETED Phase 1 14 participants

Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases

H. Lee Moffitt Cancer Center and Research Institute

NCT03807765

COMPLETED NA 11 participants

Analyzing Preoperative Stereotactic Radiosurgery With Gamma Knife Icon for Brain Metastases

Medical College of Wisconsin

NCT04545814

COMPLETED Phase 2 9 participants

Treatment of Brain Metastases From Breast Cancer With Eribulin Mesylate

Case Comprehensive Cancer Center

NCT02581839

COMPLETED Phase 1 9 participants

Satraplatin in Children and Young Adults With Refractory Solid Tumors Including Brain Tumors

National Cancer Institute (NCI)

NCT01259479

COMPLETED 7 participants

CNS and Extracranial Tumor Tissues, CSF, and Blood From Patients With Melanoma Brain Metastases

University of Pittsburgh

NCT02058953

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Phase Distribution

PhaseTrial count
Phase 1 22
Phase 2 26
Phase 3 2
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Brain Metastases Trial Landscape

68 indexed Brain Metastases studies · 41 recruiting (60%).

Phase mix: 3 late (III/IV) vs 48 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (7 trials), 9 others listed. 18 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Brain Metastases?

PlainTrial tracks 68 US clinical trials for Brain Metastases, of which 41 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Brain Metastases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.