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Brain Metastases: early-phase trial registry
41 of 68 indexed Brain Metastases trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #203 of 28,707 conditions by registered trial count.
68 US clinical trials · 41 currently recruiting · #203 of 28,707 conditions by registered trial count
Brain Metastases: 68 US clinical trials tracked, 41 recruiting.
Brain Metastases is the subject of 68 registered US clinical trials on ClinicalTrials.gov, 41 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 48 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 7 of these trials.
Enrollment posture brief
Registry condition brain-metastases
OPEN 41 | RECR 60% | LATE 3 | EARLY 48 | RANK #203 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Opioid Use Disorder (60% recruiting · 258 trials)
Brain Metastases lists 41 open slots (60% of 68 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Brain Metastases on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Brain Metastases is recruiting above its size-band peers.
41 of 68 indexed trials (60.3%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Brain Metastases trials is spread across many organizations.
M.D. Anderson Cancer Center accounts for 7 of 68 trials (10.3%). 45 distinct sponsors appear on at least one study for this condition label.
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Most Brain Metastases trials plan to enrol fewer than 100 people.
Median target enrolment is 46 among the 68 trials that report a genuine target (sentinel values excluded). 53 of those (77.9%) plan for fewer than 100 participants.
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Brain Metastases research is mostly interventional.
62 interventional and 6 observational studies make up this index (91.2% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
68 total, page 2 of 2
Study Assessing QBS72S For Treating Brain Metastases
Stanford University
NCT05305365
GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases
Memorial Sloan Kettering Cancer Center
NCT04192981
A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors
Memorial Sloan Kettering Cancer Center
NCT06209567
A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain
Memorial Sloan Kettering Cancer Center
NCT06132945
An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma.
BBB-Therapeutics B.V.
NCT01386580
ANG1005 in Breast Cancer Patients With Recurrent Brain Metastases
Angiochem
NCT02048059
MK-3475 in Melanoma and NSCLC Patients With Brain Metastases
Yale University
NCT02085070
MRI Study of Changes in Blood-Brain/Tumor-Barrier Permeability in Patients With Brain Metastases During and After Radiotherapy
University of Michigan Rogel Cancer Center
NCT02031237
GliaSite 1-3 Mets Study
Hologic
NCT00589212
Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases
Kadmon Corporation
NCT02616393
Dose-Escalation Study of RRx-001 in Combination With Whole Brain Radiation in Subjects With Brain Metastases
EpicentRx
NCT02215512
DM-CHOC-PEN for Brain Tumors in AYA Subjects
DEKK-TEC
NCT03668847
Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT00838929
Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases
H. Lee Moffitt Cancer Center and Research Institute
NCT03807765
Analyzing Preoperative Stereotactic Radiosurgery With Gamma Knife Icon for Brain Metastases
Medical College of Wisconsin
NCT04545814
Treatment of Brain Metastases From Breast Cancer With Eribulin Mesylate
Case Comprehensive Cancer Center
NCT02581839
Satraplatin in Children and Young Adults With Refractory Solid Tumors Including Brain Tumors
National Cancer Institute (NCI)
NCT01259479
CNS and Extracranial Tumor Tissues, CSF, and Blood From Patients With Melanoma Brain Metastases
University of Pittsburgh
NCT02058953
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 22 |
| Phase 2 | 26 |
| Phase 3 | 2 |
| Phase 4 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Brain Metastases records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Brain Metastases trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Brain Metastases page
68 registered trials, 41 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 41 Brain Metastases trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- M.D. Anderson Cancer Center sponsors the most Brain Metastases trials on record, review their full trial history before evaluating a specific study. See M.D. Anderson Cancer Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Brain Metastases condition card totals 68 registered trials; most-linked intervention Stereotactic Radiosurgery; top US site state Texas. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.