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Brain Metastases clinical trials
41 of 68 indexed Brain Metastases trials are currently recruiting.
68 US clinical trials · 41 currently recruiting
Brain Metastases is the subject of 68 registered US clinical trials on ClinicalTrials.gov, 41 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 48 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 7 of these trials.
The research picture
Brain Metastases has 68 registered US clinical trials, 41 of them open to new participants right now, about 60% of the total.
- 41
- recruiting participants now
- 60%
- of trials open to enrollment
- 3
- in Phase 3–4 (later-stage)
- 7
- top sponsor: M.D. Anderson Cancer Center
Active & Recent Trials
68 total, page 2 of 2
Study Assessing QBS72S For Treating Brain Metastases
Stanford University
NCT05305365
GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases
Memorial Sloan Kettering Cancer Center
NCT04192981
A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors
Memorial Sloan Kettering Cancer Center
NCT06209567
A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain
Memorial Sloan Kettering Cancer Center
NCT06132945
An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma.
BBB-Therapeutics B.V.
NCT01386580
ANG1005 in Breast Cancer Patients With Recurrent Brain Metastases
Angiochem
NCT02048059
MK-3475 in Melanoma and NSCLC Patients With Brain Metastases
Yale University
NCT02085070
MRI Study of Changes in Blood-Brain/Tumor-Barrier Permeability in Patients With Brain Metastases During and After Radiotherapy
University of Michigan Rogel Cancer Center
NCT02031237
GliaSite 1-3 Mets Study
Hologic
NCT00589212
Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases
Kadmon Corporation
NCT02616393
Dose-Escalation Study of RRx-001 in Combination With Whole Brain Radiation in Subjects With Brain Metastases
EpicentRx
NCT02215512
DM-CHOC-PEN for Brain Tumors in AYA Subjects
DEKK-TEC
NCT03668847
Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
NCT00838929
Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases
H. Lee Moffitt Cancer Center and Research Institute
NCT03807765
Analyzing Preoperative Stereotactic Radiosurgery With Gamma Knife Icon for Brain Metastases
Medical College of Wisconsin
NCT04545814
Treatment of Brain Metastases From Breast Cancer With Eribulin Mesylate
Case Comprehensive Cancer Center
NCT02581839
Satraplatin in Children and Young Adults With Refractory Solid Tumors Including Brain Tumors
National Cancer Institute (NCI)
NCT01259479
CNS and Extracranial Tumor Tissues, CSF, and Blood From Patients With Melanoma Brain Metastases
University of Pittsburgh
NCT02058953
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 22 |
| Phase 2 | 26 |
| Phase 3 | 2 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Brain Metastases Trial Landscape
68 indexed Brain Metastases studies · 41 recruiting (60%).
Phase mix: 3 late (III/IV) vs 48 early (I/II).
Top sponsor: M.D. Anderson Cancer Center (7 trials), 9 others listed. 18 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Brain Metastases?
PlainTrial tracks 68 US clinical trials for Brain Metastases, of which 41 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Brain Metastases?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.