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NCT07222488 · ClinicalTrials.gov registry record · Phase 1
A Clinical Study of MK-3120 in People With Bladder Cancer (MK-3120-003)
A Phase 1 study of Bladder Cancer and Urinary Bladder Neoplasms, sponsored by Merck Sharp & Dohme.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 45
- Enrollment target
- 5
- Study locations
NCT07222488 is a Phase 1 study of Bladder Cancer and Urinary Bladder Neoplasms that is actively recruiting participants, run by Merck Sharp & Dohme. The registered enrollment target is 45 participants, below the 12,753-participant average among 175 other Bladder Cancer trials with a reported enrollment target (100% lower). The trial reports 5 study locations across 4 states.
The verdict
NCT07222488, a Phase 1 study of Bladder Cancer and Urinary Bladder Neoplasms, is actively recruiting participants, sponsored by Merck Sharp & Dohme.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 45 participants
- Enrollment target
- 5
- Study locations
Study Summary
Researchers are looking for new ways to treat high-risk non-muscle invasive bladder cancer (HR NMIBC). NMIBC is cancer in the tissue that lines the inside of the bladder and has not spread to the bladder muscle or outside of the bladder. In standard treatment for HR NMIBC, doctors first remove the tumor with a procedure called transurethral resection of the bladder tumor (TURBT). Researchers want to learn if using MK-3120, the study medicine, can treat HR NMIBC after TURBT. The goal of this study is to learn about the safety of MK-3120 and if people tolerate it.
Conditions Studied
Interventions
- BIOLOGICAL MK-3120
Study Locations (5)
Other
- Rabin Medical Center ( Site 0062) - Petah Tikva
- Ankara University Health Practice and Research Hospitals ( Site 0132) - Ankara
California
- Michael G Oefelein Clinical Trials ( Site 0005) - Bakersfield
South Carolina
- Carolina Urologic Research Center ( Site 0006) - Myrtle Beach
Quebec
- CHU de Quebec - Hopital de l'Enfant-Jesus ( Site 0011) - Québec
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2025-12-09 |
| Est. Completion | 2029-02-28 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07222488
The ClinicalTrials.gov registry entry for NCT07222488 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 12,753-participant average among 175 other Bladder Cancer trials with a reported enrollment target (100% lower). The listed sponsor is Merck Sharp & Dohme, which has 558 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Bladder Cancer appearing as the primary indexed condition, and to 1 intervention - of which MK-3120 is the first listed.
NCT07222488 reports 5 study locations spanning 4 distinct geographic areas - top geographies include Other, California, South Carolina.
Frequently Asked Questions
What is clinical trial NCT07222488 about?
NCT07222488 is a clinical study titled "A Clinical Study of MK-3120 in People With Bladder Cancer (MK-3120-003)". Researchers are looking for new ways to treat high-risk non-muscle invasive bladder cancer (HR NMIBC). NMIBC is cancer in the tissue that lines the inside of the bladder and has not spread to the bladder muscle or outside of the bladder. In standard treatment for HR NMIBC, doctors first remove the t...
What is the current status of trial NCT07222488?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 45 participants. The study started on 2025-12-09. Estimated completion is 2029-02-28.
What conditions does trial NCT07222488 study?
This clinical trial studies the following conditions: Bladder Cancer, Urinary Bladder Neoplasms.
What interventions are being tested in trial NCT07222488?
The interventions under investigation include: MK-3120 (BIOLOGICAL).
Who is sponsoring clinical trial NCT07222488?
This trial is sponsored by Merck Sharp & Dohme, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07222488 being conducted?
This trial has 5 study locations across California, South Carolina, Quebec. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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