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ClinicalTrials.gov 74 recruiting now official registry

Bladder Cancer clinical trials

74 of 179 indexed Bladder Cancer trials are currently recruiting.

179 US clinical trials · 74 currently recruiting

Bladder Cancer is the subject of 179 registered US clinical trials on ClinicalTrials.gov, 74 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 84 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 17 of these trials.

The research picture

Bladder Cancer has 179 registered US clinical trials, 74 of them open to new participants right now, about 41% of the total.

74
recruiting participants now
41%
of trials open to enrollment
14
in Phase 3–4 (later-stage)
17
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 139Phase 245Phase 314

Active & Recent Trials

179 total, page 3 of 4

ACTIVE NOT RECRUITING NA 98 participants

3 Tesla MRI in Patients With Bladder Cancer

University of Cincinnati

NCT00938145

ACTIVE NOT RECRUITING 80 participants

Evaluating Bladder CARE™, a New Non-Invasive Urine Test, for Bladder Cancer Detection in Inconclusive Cases

Pangea Laboratory

NCT06870253

ACTIVE NOT RECRUITING Phase 2 69 participants

A Study of Several Radiation Doses for Patients With Progression on Immunotherapy/Checkpoint Inhibitors

Memorial Sloan Kettering Cancer Center

NCT03693014

ACTIVE NOT RECRUITING Phase 1 54 participants

A Phase II Study of Atezolizumab in Combination With Cisplatin + Gemcitabine Before Surgery to Remove the Bladder Cancer

Memorial Sloan Kettering Cancer Center

NCT02989584

ACTIVE NOT RECRUITING Phase 2 52 participants

A Study to Test the Safety of Immunotherapy With Nivolumab Alone or With Ipilimumab Before Surgery for Bladder Cancer Patients Who Are Not Suitable for Chemotherapy

Memorial Sloan Kettering Cancer Center

NCT03520491

ACTIVE NOT RECRUITING Phase 1 48 participants

CAR-macrophages for the Treatment of HER2 Overexpressing Solid Tumors

Carisma Therapeutics

NCT04660929

ACTIVE NOT RECRUITING Phase 2 46 participants

Study of CAbozantinib in Combination with AtezolizumaB for Muscle-Invasive BladdEr Cancer

Deepak Kilari

NCT04289779

ACTIVE NOT RECRUITING Phase 2 46 participants

Fluorouracil, Leucovorin, Gemcitabine, and Cisplatin in Treating Patients With Metastatic or Unresectable Adenocarcinoma of the Urothelium or Urachal Remnant

M.D. Anderson Cancer Center

NCT00082706

ACTIVE NOT RECRUITING Phase 2 45 participants

Pembrolizumab (MK-3475) and Bacillus Calmette-Guérin (BCG) as First-Line Treatment for High-Risk T1 Non-Muscle-Invasive Bladder Cancer (NMIBC) and High-Grade Non-Muscle-Invasive Upper Tract Urothelial Carcinoma (NMI-UTUC)]

Memorial Sloan Kettering Cancer Center

NCT03504163

ACTIVE NOT RECRUITING Phase 1 40 participants

Study of AB598 Monotherapy and Combination Therapy in Participants With Advanced Cancers

Arcus Biosciences

NCT05891171

ACTIVE NOT RECRUITING NA 35 participants

Integrated Actionable Aging Assessment for Cancer Patients Pilot

University of Colorado, Denver

NCT05871008

ACTIVE NOT RECRUITING Phase 2 31 participants

Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Urothelium

M.D. Anderson Cancer Center

NCT00756639

ACTIVE NOT RECRUITING Phase 2 27 participants

Intravesical Gemcitabine and Docetaxel for BCG naïve Non-muscle Invasive Bladder Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT04386746

ACTIVE NOT RECRUITING Early Phase 1 20 participants

(CLONEVO): Cell cycLe inhbitiON to Target the EVolution of UrOthelial Cancer

Weill Medical College of Cornell University

NCT03837821

ACTIVE NOT RECRUITING Phase 2 20 participants

Window of Opportunity Study of Pembrolizumab Alone and in Combinations in Bladder Cancer

UNC Lineberger Comprehensive Cancer Center

NCT03978624

ACTIVE NOT RECRUITING Phase 2 20 participants

A Study of Oral Erdafitinib in People With Recurrent Non-Invasive Bladder Cancer

Memorial Sloan Kettering Cancer Center

NCT04917809

ACTIVE NOT RECRUITING Early Phase 1 16 participants

18Fluorine-Fluciclovine PET/CT for Staging Muscle Invasive Bladder Cancer Preceding Radical Cystectomy

Brigham and Women's Hospital

NCT04018053

ACTIVE NOT RECRUITING Phase 2 15 participants

Neoadjuvant Nivolumab With and Without Urelumab in Cisplatin-Ineligible or Chemotherapy-refusing Patients With Muscle-Invasive Urothelial Carcinoma of the Bladder

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT02845323

ACTIVE NOT RECRUITING Phase 1 12 participants

Intravenous (IV) Vitamin C With Chemotherapy for Cisplatin Ineligible Bladder Cancer Patients

University of Kansas Medical Center

NCT04046094

ACTIVE NOT RECRUITING Phase 2 12 participants

A Phase II Multicenter Study of Chemotherapy Versus Chemotherapy Plus Durvalumab (MEDI 4736) in Patients With Lymph Node Positive Urothelial Carcinoma of the Bladder

M.D. Anderson Cancer Center

NCT05137262

ACTIVE NOT RECRUITING Phase 1 10 participants

A Window of Opportunity Phase I Study of UGN-201 in Patients With Bladder Cancer Undergoing Radical Cystectomy Protocol #: 2021-0630

M.D. Anderson Cancer Center

NCT05055050

COMPLETED 2,133,575 participants

Cancer in Patients on Dapagliflozin and Other Antidiabetic Treatment

AstraZeneca

NCT02695121

COMPLETED 2,681 participants

The New England Bladder Cancer Study

National Cancer Institute (NCI)

NCT00342875

COMPLETED Phase 3 812 participants

Single Dose Intravesical Apaziquone Postoperative in Patients Undergoing TURBT for Noninvasive Bladder Cancer (SPI-612)

Spectrum Pharmaceuticals

NCT00598806

COMPLETED NA 680 participants

The Efficacy of the Bladder EpiCheck for Detection of Recurrent Urothelial Cell Carcinoma

Nucleix

NCT02700464

COMPLETED 600 participants

Survivin Urine mRNA Assay Risk of Bladder Cancer Study

Fujirebio Diagnostics

NCT00315653

COMPLETED 600 participants

Bladder Cancer Case Control Study of Arsenic in Water

National Institute of Environmental Health Sciences (NIEHS)

NCT00011518

COMPLETED NA 529 participants

A Comparison of the Studer Pouch Versus the T-Pouch Orthotopic Neobladder Urinary Diversion in Bladder Cancer Patients

University of Southern California

NCT01008865

COMPLETED Phase 3 450 participants

Eflornithine in Treating Patients With Bladder Cancer

National Cancer Institute (NCI)

NCT00003814

COMPLETED Phase 2 310 participants

A Study of Atezolizumab in Participants With Locally Advanced or Metastatic Urothelial Bladder Cancer (Cohort 2)

Hoffmann-La Roche

NCT02108652

COMPLETED NA 219 participants

UC-GENOME: Urothelial Cancer-GENOmic Analysis to iMprove Patient Outcomes and rEsearch

Matthew Milowsky, MD

NCT02643043

COMPLETED 197 participants

Screening for Bladder Cancer

Baylor College of Medicine

NCT00848627

COMPLETED 195 participants

Fiber-Optic Confocal Microscopy of the Urinary Tract Histopathology

Stanford University

NCT00801762

COMPLETED Phase 3 161 participants

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Dan Zandberg

NCT04157985

COMPLETED 138 participants

Health-Related Quality of Life in Patients With Bladder Cancer

David Latini

NCT00744744

COMPLETED Phase 3 133 participants

Vicinium Treatment for Subjects With Non-muscle Invasive Bladder Cancer Previously Treated With BCG

Sesen Bio

NCT02449239

COMPLETED Phase 2 119 participants

A Study of Atezolizumab in Participants With Locally Advanced or Metastatic Urothelial Bladder Cancer (Cohort 1)

Hoffmann-La Roche

NCT02951767

COMPLETED 116 participants

Genetic Susceptibility to Tumor Recurrence and Progression in Patients With Non-Muscle Invasive Bladder Cancer

Memorial Sloan Kettering Cancer Center

NCT00582387

COMPLETED Phase 3 114 participants

A Study of Nivolumab Plus Bempegaldesleukin (Bempeg/NKTR-214) vs Nivolumab Alone vs Standard of Care in Participants With Bladder Cancer That May Have Invaded The Muscle Wall of the Bladder and Who Cannot Get Cisplatin, A Type of Medicine Given To Treat Bladder Cancer

Bristol-Myers Squibb

NCT04209114

COMPLETED Phase 2 109 participants

Docetaxel in Treating Patients With Solid Tumors

Alliance for Clinical Trials in Oncology

NCT00003565

COMPLETED NA 95 participants

PlasmaKinetic (PK) Button Vaporization Electrode for Treatment of Bladder Tumors

Emory University

NCT01567462

COMPLETED Phase 2 90 participants

Intravesical AD 32 (Valrubicin) in Patients With Carcinoma in Situ (CIS) of the Bladder Who Have Failed or Have Recurrence Following Treatment With Bacillus Calmette-guerin (BCG)

Endo Pharmaceuticals

NCT01316874

COMPLETED Phase 2 81 participants

Relationship Between Tumor Mutation Burden and Predicted Neo-antigen Burden in Patients With Advanced Melanoma or Bladder Cancer Treated With Nivolumab or Nivolumab Plus Ipilimumab (CA209-260)

Memorial Sloan Kettering Cancer Center

NCT02553642

COMPLETED 80 participants

Using PROMIS as Part of Routine Clinical Care for Racially Diverse Prostate and Bladder Cancer Patients

UNC Lineberger Comprehensive Cancer Center

NCT03156244

COMPLETED Phase 1 78 participants

A Phase 1a/b Study of IK-175 as a Single Agent and in Combination With Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumors and Urothelial Carcinoma

Ikena Oncology

NCT04200963

COMPLETED Phase 2 75 participants

Chemotherapy in Treating Patients With Early-Stage Bladder Cancer

Eastern Cooperative Oncology Group

NCT00003129

COMPLETED 74 participants

Resiliency in Patients Undergoing Radical Cystectomy for Bladder Cancer

University of Kansas Medical Center

NCT06337305

COMPLETED 68 participants

Physical Therapy in Pre-cystectomy Patients

UNC Lineberger Comprehensive Cancer Center

NCT05978570

COMPLETED NA 64 participants

FITBIT Study on Mobility and Readmissions After Radical Cystectomy

University of Pennsylvania

NCT04314778

COMPLETED Phase 1 54 participants

INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors

Incyte Corporation

NCT04580485

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Phase Distribution

PhaseTrial count
Phase 1 39
Phase 2 45
Phase 3 14

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Bladder Cancer Trial Landscape

179 indexed Bladder Cancer studies · 74 recruiting (41%).

Phase mix: 14 late (III/IV) vs 84 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (17 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Bladder Cancer?

PlainTrial tracks 179 US clinical trials for Bladder Cancer, of which 74 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Bladder Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.