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CISTO: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer
NCT03933826 · View on ClinicalTrials.gov ↗
Study Summary
Bladder cancer is the most common urinary tract cancer and the 5th most common cancer in the US (1). Yet bladder cancer research is underfunded relative to other common cancers. As a result, bladder cancer care is prone to evidence gaps that produce decision uncertainty for both patients and clinicians. The Comparison of Intravesical Therapy and Surgery as Treatment Options (CISTO) for Bladder Cancer Study has the potential to fill these critical evidence gaps, change care pathways for the management of non-muscle-invasive bladder cancer (NMIBC), and provide for personalized, patient-centered care. The purpose of CISTO is to conduct a large prospective study that directly compares the impact of medical management versus bladder removal in recurrent high-grade NMIBC patients with Bacillus Calmette-Guerin (BCG) failure on clinical outcomes and patient and caregiver experience using standardized patient-reported outcomes (PROs).
Conditions Studied
Study Locations (20)
California
- USC/Norris Comprehensive CA Center — Los Angeles
- UCLA — Los Angeles
- Hoag Memorial Hospital Presbyterian — Newport Beach
Michigan
- Michigan Medicine Rogel Cancer Center — Ann Arbor
- Spectrum Health — Grand Rapids
- Comprehensive Urology -- A Division of Michigan Healthcare Professionals — Royal Oak
Florida
- University of Miami — Miami
- H. Lee Moffitt Cancer Center & Research Institute — Tampa
Maryland
- Johns Hopkins University, School of Medicine — Baltimore
- Chesapeake Urology Research Associates — Hanover
Alabama
- University of Alabama at Birmingham — Birmingham
Arizona
- Mayo Clinic Cancer Center — Phoenix
Colorado
- University of Colorado Anschutz Medical Campus — Aurora
Georgia
- Emory University — Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 570 participants |
| Start Date | 2019-07-09 |
| Est. Completion | 2029-06-30 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03933826
The ClinicalTrials.gov registry entry for NCT03933826 describes a study currently listed as active not recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 570 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Washington, which has 987 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Bladder Cancer appearing as the primary indexed condition, and to 0 interventions. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03933826 reports 20 study locations spanning 14 distinct geographic areas — top geographies include California, Michigan, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03933826 about?
NCT03933826 is a clinical study titled "CISTO: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer". Bladder cancer is the most common urinary tract cancer and the 5th most common cancer in the US (1). Yet bladder cancer research is underfunded relative to other common cancers. As a result, bladder cancer care is prone to evidence gaps that produce decision uncertainty for both patients and clinici...
What is the current status of trial NCT03933826?
This trial is currently active not recruiting. The enrollment target is 570 participants. The study started on 2019-07-09. Estimated completion is 2029-06-30.
What conditions does trial NCT03933826 study?
This clinical trial studies the following conditions: Bladder Cancer, Non-muscle Invasive Bladder Cancer, Cancer of the Bladder, Recurrent. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
Who is sponsoring clinical trial NCT03933826?
This trial is sponsored by University of Washington, which has 987 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03933826 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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